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Two proteins central to the pathology of Alzheimer’s disease act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — according to new UC San Francisco research.
Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of the proteins amyloid beta (Aß) and tau in postmortem brain tissue of 75 Alzheimer’s patients. In a striking finding, higher levels of these prions in human brain samples were strongly associated with early-onset forms of the disease and younger age at death.
Alzheimer’s disease is currently defined based on the presence of toxic protein aggregations in the brain known as amyloid plaques and tau tangles, accompanied by cognitive decline and dementia. But attempts to treat the disease by clearing out these inert proteins have been unsuccessful. The new evidence that active Aß and tau prions could be driving the disease – published May 1, 2019 in Science Translational Medicine — could lead researchers to explore new therapies that focus on prions directly.
“I believe this shows beyond a shadow of a doubt that amyloid beta and tau are both prions, and that Alzheimer’s disease is a double-prion disorder in which these two rogue proteins together destroy the brain,” said Stanley Prusiner, MD, the study’s senior author and director of the UCSF Institute for Neurodegenerative Diseases, part of the UCSF Weill Institute for Neurosciences. “The fact that prion levels also appear linked to patient longevity should change how we think about the way forward for developing treatments for the disease. We need a sea change in Alzheimer’s disease research, and that is what this paper does. This paper might catalyze a major change in AD research.”
(Score: 3, Informative) by noneof_theabove on Saturday May 04 2019, @12:44AM (4 children)
my father is late stage alz and mom is not far behind.
Dad "fell off the cliff" in Aug 2018.
Follow a "cancer" diet life style and you might avoid it.
Rule #1: NO SUGAR
#2: nothing that is white and converts directly to sugar
Exception: for sweet tooth stivia and xylytol are fine.
#3: small serving of quality chicken or fish a week, organic, wild-caught alaska
#4: small serving of quality beef per month.
#5: no dairy or animal, except cottage cheese on Budwig Diet or a 2 eggs a weeks
otherwise nuts, seeds including apricot [6 per day], all veggies, low to moderate fruit - it is sugar
Our food is our down fall.
(Score: 0) by Anonymous Coward on Saturday May 04 2019, @01:19AM (1 child)
It sounds like the diet is eating a small serving of white meat once a week, a small serving of red meat once a month, and 2 eggs per week.
(Score: 0, Troll) by Ethanol-fueled on Saturday May 04 2019, @02:59AM
Sounds like something a Globalist shitbag would say while he's trying to convince his workers that they need to eat bugs like bushniggers every day.
(Score: -1, Flamebait) by Anonymous Coward on Saturday May 04 2019, @09:05AM
Are you Jordan Peterson, or his daughter?
(Score: 0) by Anonymous Coward on Saturday May 04 2019, @06:25PM
and i wonder if autophagy would remove these and other mutated proteins. if so 2-3 day fasts could prevent and/or cure this and other diseases.