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posted by janrinok on Tuesday September 10 2019, @12:09PM   Printer-friendly
from the it's-been-weighing-on-my-mind dept.

Submitted via IRC for Bytram

Why people gain weight as they get older

The scientists studied the fat cells in 54 men and women over an average period of 13 years. In that time, all subjects, regardless of whether they gained or lost weight, showed decreases in lipid turnover in the fat tissue, that is the rate at which lipid (or fat) in the fat cells is removed and stored. Those who didn't compensate for that by eating less calories gained weight by an average of 20 percent, according to the study which was done in collaboration with researchers at Uppsala University in Sweden and University of Lyon in France.

The researchers also examined lipid turnover in 41 women who underwent bariatric surgery and how the lipid turnover rate affected their ability to keep the weight off four to seven years after surgery. The result showed that only those who had a low rate before the surgery managed to increase their lipid turnover and maintain their weight loss. The researchers believe these people may have had more room to increase their lipid turnover than those who already had a high-level pre-surgery.

"The results indicate for the first time that processes in our fat tissue regulate changes in body weight during ageing in a way that is independent of other factors," says Peter Arner, professor at the Department of Medicine in Huddinge at Karolinska Institutet and one of the study's main authors. "This could open up new ways to treat obesity."

Prior studies have shown that one way to speed up the lipid turnover in the fat tissue is to exercise more. This new research supports that notion and further indicates that the long-term result of weight-loss surgery would improve if combined with increased physical activity.

"Obesity and obesity-related diseases have become a global problem," says Kirsty Spalding, senior researcher at the Department of Cell and Molecular Biology at Karolinska Institutet and another of the study's main authors. "Understanding lipid dynamics and what regulates the size of the fat mass in humans has never been more relevant."

P. Arner, et.al. Adipose lipid turnover and long-term changes in body weight. Nature Medicine, 2019; 25 (9): 1385 DOI: 10.1038/s41591-019-0565-5


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  • (Score: 2) by maxwell demon on Wednesday September 11 2019, @09:32AM (1 child)

    by maxwell demon (1608) on Wednesday September 11 2019, @09:32AM (#892596) Journal

    Average BMI for someone my height, weight, and waist size

    People with your height and weight have exactly the same BMI as you because the BMI is, by definition, a function of height and weight. No averaging needed.

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  • (Score: 2) by The Mighty Buzzard on Wednesday September 11 2019, @11:09AM

    by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Wednesday September 11 2019, @11:09AM (#892615) Homepage Journal

    Fair nuff. In which case it's not really a useful metric at all unless you're near average in muscle mass to fat mass ratio as well, which I'm not. I'm not hugely bulked up except for my legs but I've got plenty of muscle and it's all working muscle rather than show muscle (More dense and slower to fade. Bodybuilders would know what I mean.).

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