Stories
Slash Boxes
Comments

SoylentNews is people

posted by martyb on Sunday September 22 2019, @08:06PM   Printer-friendly
from the "All-the-better-to-smell-you-with,-my-dear" dept.

Arthur T Knackerbracket has found the following story:

Vampire bats may hold the key to unraveling the mysteries of smell, according to research by an international team of scientists led by Stony Brook's Laurel Yohe.

Their findings, published this week in Molecular Ecology Resources, suggest a new method to quantify olfactory receptors by sequencing them in vampire bats.

Understanding how to obtain accurate numbers of olfactory receptor counts in the mammalian genome is major aspect to understanding the sense of smell, according to Yohe, a PhD alumna and affiliated research associate in the lab of Liliana Dávalos in Stony Brook's Department of Ecology and Evolution, as well as a National Science Foundation Postdoctoral Fellow at Yale University.

The difficulty is that genes related to smell are highly similar to one another, and therefore determining the correct sequencing of the hundreds of olfactory receptors is difficult and similar to analyzing many pieces of a puzzle that are nearly the same.

The researchers selected the vampire bat to compare for the first time different ways to sequence olfactory receptors. The vampire bat relies on its sense of smell to find its prey and has a comparable number of olfactory receptors to humans (approximately 400). They compared different methods to get the DNA sequences of olfactory receptor genes using the vampire bat genome. The methods ranged from traditional polymerase chain reaction (PCR) and cloning to newer technologies to probe sequences of bat olfactory receptors.

They discovered that an approach called "targeted sequence capture," which involves the researchers to design generic 'search' motifs that 'bait' olfactory receptors. This makes for a quick and efficient sequencing of the olfactory receptors. By using this method, they discovered a fast and cost-effective method to find up to 90 percent of the genes involved in smell. The method also found almost four times the amount of intact olfactory receptors as was previously reported in published works.

"The comparison study changes our interpretation of what constitutes a good smeller," says Yohe. "Our method makes it feasible to probe the DNA behind the sense of smell, across hundreds of species and thousands of genes, which may ultimately illuminate some of the mysteries behind the sense of smell."


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: 2) by Freeman on Monday September 23 2019, @04:45PM

    by Freeman (732) on Monday September 23 2019, @04:45PM (#897656) Journal

    'eh, but as they say the Early Bird gets the worm. I don't see what Robin's happiness has to do with anything, though.

    --
    Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2