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"exec" writes:

Arthur T Knackerbracket has found the following story:

Titanium has many properties that make it a great choice for use in implants. Its low density, high stiffness, high biomechnanical strength-to-weight ratio, and corrosion resistance have led to its use in several types of implants, from dental to joints. However, a persistent problem plagues metal-based implants: the surface is also a perfect home for microbes to accumulate, causing chronic infections and inflammation in the surrounding tissue. Consequently, five to 10 percent of dental implants fail and must be removed within 10-15 years to prevent infection in the blood and other organs.

New research from the University of Pittsburgh's Swanson School of Engineering introduces a revolutionary treatment for these infections. The group, led by Tagbo Niepa, PhD, is utilizing electrochemical therapy (ECT) to enhance the ability of antibiotics to eradicate the microbes.

[...] The novel method passes a weak electrical current through the metal-based implant, damaging the attached microbe's cell membrane but not harming the surrounding healthy tissue. This damage increases permeability, making the microbe more susceptible to antibiotics. Since most antibiotics specifically work on cells that are going to replicate, they do not work on dormant microbes, which is how infections can recur. The ECT causes electrochemical stress in all the cells to sensitize them, making them more susceptible to antibiotics.

The researchers hope this technology will change how infections are treated. Researchers focused their research on Candida albicans (C. albicans), one of the most common and harmful fungal infections associated with dental implants. But while dental implants are one exciting application for this new technology, Niepa says it has other potential applications, such as in wound dressings.

-- submitted from IRC

Journal Reference:

Eloise Eyo Parry-Nweye, Nna-Emeka Onukwugha, Sricharani Rao Balmuri, Jackie L Shane, Dongyeop Kim, Hyun Koo, Tagbo Niepa. Electrochemical Strategy for Eradicating Fluconazole-Tolerant Candida albicans using Implantable Titanium. ACS Applied Materials & Interfaces, 2019; DOI: 10.1021/acsami.9b09977

Original Submission