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Finding a new way to fight late-stage sepsis by boosting cells' antibacterial properties:
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection.
The scientists used nanotechnology to transform donated healthy immune cells into a drug with enhanced power to kill bacteria.
In experiments treating mice with sepsis, the engineered immune cells eliminated bacteria in blood and major organs, dramatically improving survival rates.
This work focuses on a treatment for late-stage sepsis, when the immune system is compromised and unable to clear invading bacteria. The scientists are collaborating with clinicians specializing in sepsis treatment to accelerate the drug-development process.
"Sepsis remains the leading cause of death in hospitals. There hasn't been an effective treatment for late-stage sepsis for a long time. We're thinking this cell therapy can help patients who get to the late stage of sepsis," said Yizhou Dong, senior author and associate professor of pharmaceutics and pharmacology at The Ohio State University. "For translation in the clinic, we believe this could be used in combination with current intensive-care treatment for sepsis patients."
The study is published today in Nature Nanotechnology.
Sepsis itself is not an infection—it's a life-threatening systemic response to infection that can lead to tissue damage, organ failure and death, according to The Centers for Disease Control and Prevention. The CDC estimates that 1.7 million adults in the United States develop sepsis each year, and one in three patients who die in a hospital have sepsis.
This work combined two primary types of technology: using vitamins as the main component in making lipid nanoparticles, and using those nanoparticles to capitalize on natural cell processes in the creation of a new antibacterial drug. Cells called macrophages are one of the first responders in the immune system, with the job of "eating" invading pathogens. However, in patients with sepsis, the number of macrophages and other immune cells are lower than normal and they don't function as they should.
Journal Reference:
Xucheng Hou, Xinfu Zhang, Weiyu Zhao, Chunxi Zeng, Binbin Deng, David W. McComb, Shi Du, Chengxiang Zhang, Wenqing Li, Yizhou Dong, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology (2020). DOI: 10.1038/s41565-019-0600-1 , https://nature.com/articles/s41565-019-0600-1
(Score: 0) by Anonymous Coward on Wednesday January 08 2020, @04:53PM (2 children)
Hear! Here!
Vit C is not stored, and any not being used will be excreted in the urine. Thus a steady supply of it is needed, especially when you are sick and not eating and drinking as normal.
An excess is literally pissed away.
rts008
(Score: 0) by Anonymous Coward on Wednesday January 08 2020, @07:07PM (1 child)
First, say you take vitamin C and it reacts with a free radical to quench it in your body. The process converts it to dehydroascorbate which makes it back to the blood. Red blood cells will then reduce dehydroascorbate back to the more water soluble ascorbate which (if blood levels are high enough) your kidneys will excrete.
When you measure urine vitamin C levels how do you know whether it was "used" or not?
Second, say you need to fight a forest fire but when dumping the water on it your accuracy is very low. Basically to get enough water on the actual fire to quench it, you need to just drench the entire forest. In a case like this you would need an extreme excess of water to quench the fire. This is just like a hundred gram dose of vitamin C quenching inflammation due to, eg, a viral infection in your lung.
(Score: 0) by Anonymous Coward on Wednesday January 08 2020, @10:05PM
Typo: "Red blood cells will then *oxidize* dehydroascorbate back to the more water soluble ascorbate"