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posted by janrinok on Tuesday January 14 2020, @04:29AM   Printer-friendly

Cancer: Giving entire course of radiation treatment in less than a second is feasible: Findings related to FLASH radiotherapy could pave a new path for the future for cancer therapy:

[The study's co-senior author James M. Metz, MD] noted that other research teams have generated similar doses using electrons, which do not penetrate deep enough into the body to be clinically useful as a cancer treatment for internal tumors. Other groups have tried the approach with conventional photons, but currently available treatment devices do not have the ability to generate the necessary dosage. This study shows, that with technical modifications, the currently available accelerators for protons can achieve FLASH doses with the biologic effects today.

The key for the Penn team was the ability to generate the dose with protons, and even in that setting, researchers had to specially develop the tools needed to effectively and accurately measure radiation doses, since the standard detectors were quickly saturated due to the high levels of radiation. The Roberts Proton Therapy Center includes a dedicated research room to run experiments like these, allowing investigators to use photon and proton radiation side-by-side just feet from the clinic. It's one of the few facilities in the world with those unique features, and Metz said this infrastructure is what made Penn's FLASH experiments possible.

"We've been able to develop specialized systems in the research room to generate FLASH doses, demonstrate that we can control the proton beam, and perform a large number of experiments to help us understand the implications of FLASH radiation that we simply could not have done with a more traditional research setup," Metz said.


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  • (Score: 1, Funny) by Anonymous Coward on Tuesday January 14 2020, @11:51AM (1 child)

    by Anonymous Coward on Tuesday January 14 2020, @11:51AM (#943054)

    Or, in USA, everyone expects instant gratification -- cancer treatment at a kiosk in the mall.

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  • (Score: 3, Interesting) by PiMuNu on Tuesday January 14 2020, @12:37PM

    by PiMuNu (3823) on Tuesday January 14 2020, @12:37PM (#943064)

    > in USA, everyone expects instant gratification

    sniping aside:-

    Note that there is some evidence that under FLASH regime, patient outcomes are better; there is less damage to healthy tissue for the same amount of damage on cancerous tissues. I don't believe there is a proper understanding of the mechanism by which this occurs.

    Further, fast treatments can be very helpful for cancers that are on moving bits of body (e.g. lungs). It is highly challenging to force a beam to track a cancer that is moving during the treatment. A short pulse treatment can be very beneficial in this instance.

    Finally, while throughput in treatment suites is primarily limited by preparation of the patient, the duration of the treatment is a thing. More people can be treated more easily with a shorter therapy.

    All in all, FLASH is a good thing, if it is shown to work. It is quite the hot topic in hadron therapy, with a couple of consortia (at least) forming in UK and no doubt more elsewhere.