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Nanoparticle chomps away plaques that cause heart attacks:
Michigan State University and Stanford University scientists have invented a nanoparticle that eats away—from the inside out—portions of plaques that cause heart attacks.
Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a "Trojan Horse" nanoparticle that can be directed to eat debris, reducing and stabilizing plaque. The discovery could be a potential treatment for atherosclerosis, a leading cause of death in the United States.
The results, published in the current issue of Nature Nanotechnology, showcases the nanoparticle that homes in on atherosclerotic plaque due to its high selectivity to a particular immune cell type—monocytes and macrophages. Once inside the macrophages in those plaques, it delivers a drug agent that stimulates the cell to engulf and eat cellular debris. Basically, it removes the diseased/dead cells in the plaque core. By reinvigorating the macrophages, plaque size is reduced and stabilized.
[...] "We found we could stimulate the macrophages to selectively eat dead and dying cells—these inflammatory cells are precursor cells to atherosclerosis—that are part of the cause of heart attacks," Smith said. "We could deliver a small molecule inside the macrophages to tell them to begin eating again."
[...] "We were able to marry a groundbreaking finding in atherosclerosis by our collaborators with the state-of-the-art selectivity and delivery capabilities of our advanced nanomaterial platform. We demonstrated the nanomaterials were able to selectively seek out and deliver a message to the very cells needed," Smith said. "It gives a particular energy to our future work, which will include clinical translation of these nanomaterials using large animal models and human tissue tests. We believe it is better than previous methods."
Smith has filed a provisional patent and will begin marketing it later this year.
Journal Reference:
Alyssa M. Flores et al. Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis$, Nature Nanotechnology (DOI: 10.1038/s41565-019-0619-3)
(Score: -1, Offtopic) by Anonymous Coward on Tuesday January 28 2020, @11:12PM (20 children)
Wrong.
I "spammed" a list of Trump's bullshit 3 times I believe was the total. Not once after that did I post a repeated message.
I have been calling out Buzzy's censorship, and if you bothered to pay attention I specifically said I did not mind the IP ban except for the hypocrisy that goes behind it. They even updated the spam rules to cover my posts, which should give you an inkling of the authoritarian nature of a certain admin.
I have not once cried about being modded down, though I did post about Thexalon being modded troll and the irony of it after all the whinging from the libertarian/conservative ACs about being "mod bombed" by liberals.
Also I did not ask for anyone to be grateful, I was simply clarifying that someone went through more effort to censor me even though I did not repeatedly post the same thing.
So your post is nonsense, but thanks for the hate it warms me like a good chipotle burrito.
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I was going to add on a little info about Athaniuskucher(sp?) who was one of the most mature and interesting users around here and how he left the site and accused TMB of deleting a journal entry of his. Then I thought I'd see how long you've been on this site which seems to be since late 2016. And what was your first journal entry?? https://soylentnews.org/~barbara+hudson/journal/2168 [soylentnews.org] Proof that Slashdot Censors posts!!!
That is interesting, very interesting.
Don't you have vision problems? I thought you were limiting your screen time to not wear out your eyes, why would you bother ranting about my complaint?
(Score: 3, Informative) by barbara hudson on Wednesday January 29 2020, @12:37AM (5 children)
So you ARE "that guy." Repeatedly posting the same post, both off-topic and off thread, is spam. How is deleting spam censorship? You don't have a right to spam.
Spamming Usenet or FidoNet warranted a permanent ban. Even back then nobody liked spam.
Do you seriously expect sympathy from people who had to put up with the birth of spam and the crazies arguing that they had a first amendment right to spam ? Ain't gonna happen, except from others who similarly want to preserve some "right to spam."
When you spam you paint a big scarlet letter on yourself and your posts. Everything after is seen through that filter. It also brings up the question of why you bothered to spam? What is so important to you that you had to repeatedly violate one of the oldest rules going? Everyone knows the rule - spam = ban. Doesn't matter if the cause is worthy - spam is spam.
As for my eyes, they're still a problem, so I rest them a lot. After yesterday, where the rib I broke in February that has never properly healed made me go home early (pneumothorax/hemothorax made it hard to breathe yet again) I'm spending my time in bed, with my dogs. But it's boring as crap. So I have my phone in my face, and while everything is a blur, I'm continuing to try to adapt. Focusing on stuff 6" away causes the lens to go more round, pushing away some of the material in the posterior cataract. Ain't science grand. Seeing as it's probably going to take years more before it finishes healing and an operation is not a smart idea with my diseased and holy retinas, it's called making the best of a bad situation.
Btw - the ban on anonymous posting on slash dot was because of spam. People just have no tolerance for spammers. So maybe you should make the most of it by not spamming , and not complaining about earning the consequences. Deleting spam isn't censorship. It's a public service.
SoylentNews is social media. Says so right in the slogan. Soylentnews is people, not tech.
(Score: -1, Offtopic) by Anonymous Coward on Wednesday January 29 2020, @02:29AM (4 children)
So I very openly admitted I copy/pasted the trump criticisms from the beginning, and it hardly qualified by this site's standards "Posts so offtopic and lacking value to even be a troll."
At worst I trolled TMB, and since he does that all the time and proudly admits it I don't see why I should be barred from using his tactics. Apparently the freedom of speech around here is "so long as you don't annoy the council." Not to mention that since he updated his journal I have not once repeated the call out. Also I never once copy/pasted the call out, manually typed every one.
That was the purpose of this particular thread, to highlight that he is going above and beyond to punish someone who has stopped the supposed spamming. Any time someone complains about racist garbage TMB says "that is what the moderation system is there for" and let me repeat, not once have I complained about being downmodded.
I do take offense to your characterization of spam, especially given the quality of posts that so frequently inhabit this site. I understand your point of view, but not the vehemence you're heaping on me.
(Score: 2, Funny) by barbara hudson on Wednesday January 29 2020, @02:59AM (3 children)
But it DOES qualify as spam
Look, it's over, it's done, it was worth reading the first time (which is why I up-modded it the first time I saw it), but that doesn't mean that it justifies repeatedly posting it of-topic and off-thread-topic. Past a certain point, it kind of justifies the label of spamming or trolling, even if that's not the intent.
Vehemence? I'm just pointing out that spam has ALWAYS been a big no-no. The biggest. Bigger than racism, naziism, antifeminism, anti-lgbt, anti-trans, whatever. It's probably something that both Democrats and Republicans can agree on (actually, they just did when they passed the latest anti-spam phone call act).
Too bad, because fried spam (Hormel Corp) is actually kind of tasty. In a white trash sort of way. Like my latest fave - bacon, egg, and cheese sandwich fried in bacon grease. Nothing quite like the taste of bread fried in bacon grease.
SoylentNews is social media. Says so right in the slogan. Soylentnews is people, not tech.
(Score: -1, Troll) by Anonymous Coward on Wednesday January 29 2020, @03:42AM
And my point here was that TMB is now putting in more censorship methods even though my IP is still banned. For the low number of times I spammed I should have at least had a "knock it off or we'll keep the IP ban in place" and had it removed. Nope, he is working overtime even while I have not spammed one little bit.
This is a new incident, and sweeping it under "you spammed deal with it" ignores the reality that a vocal and very biased poster around here is an admin that has had multiple accusations of abuse of power. Here he is at it again, though at least he has a thin veneer of credibility since I made 2 copy/paste posts and then another as a "fuck you".
Yup, totally proportional and not biased at all. I will refer you to african americans getting stiffer sentences than those of european descent as a general trend. Racist spam? TMB will get on it, he's busy right now. Criticisms of Trump? Work overtime and put in new filters ASAP!
Ok, I'm done ranting, I just can't stand his hypocrisy.
(Score: 0) by Anonymous Coward on Wednesday January 29 2020, @11:11PM (1 child)
Different AC here. I give credit to Buzzard for at least adding that to the moderator guidelines rather than it being an unwritten rule. I have concerns about how its implemented, but it's not inherently unfair like it is to impose substantial penalties when people violate unwritten standards. The wording is intentionally vague, so as to not allow people to spam the site while technically complying with the letter of the law. APK comes to mind, when he spammed Slashdot and would carefully craft posts just so he could sneak them past the lameness filter.
I see two problems with banning repetitive posts and subjecting them to the spam mod. One is that there isn't a clear distinction between modding posts spam or redundant. Blockquoting large amounts of the text from another comment with very limited original content could justifiably be modded redundant if such a comment is only posted once. Posting the same thing ten times is far less defensible. The other issue deserves more elaboration and depends on what constitutes repetitive posts.
One can easily argue that Ethanol-fueled's posts are often not constructive and can be very repetitive. He does have a habit of blaming Jews and other minorities very little of substance to the discussion. His comments are frequently defended as political satire or garden variety trolling, leading to multiple spam mods against him being overturned. I'm not saying that Ethanol-fueled's comments should or should not be modded spam, but pointing out the ambiguity in the rule and why it's unlikely to prevent further disputes over the spam mod.
(Score: 2) by barbara hudson on Thursday January 30 2020, @12:04AM
As for EthanolFueled, I posted a suggestion elsewhere in the discussion that makes the whole section 230 concern go away - verified users posts are permanent, and they can moderate. Pseudo-anonymous and anonymous posts are deleted after a certain number of hours and pseudo-anonymous users can't moderate, so no sock puppeteer moderation.
Most questionable content would self destruct after a while, so anyone who has a valid complaint will be satisfied with it being gone. Questionable posts from verified users can be investigated and if the site operators consider it's over the line, take action against the user (anything from a warning to a timeout to a permanent ban). Or if they feel the post doesn't violate site guidelines, they can tell the user to file a complaint with the police. Most won't.
EthanolFueled and others would simply see it heir posts disappear automatically, after, say, 3 hours. If they were required to use their real identity, they might want to reconsider the repercussions of their posts in the real world. And if not, face the social and legal consequences. No loss of freedom of speech, just a loss of permanence for non-validated posts, and an obligation to face the consequences of ill-advised speech.
And for the site operators, less work.
SoylentNews is social media. Says so right in the slogan. Soylentnews is people, not tech.
(Score: 2) by Azuma Hazuki on Wednesday January 29 2020, @12:54AM (13 children)
Damn it. You had so much potential, and then you went the Aristarchus route :( Please, please, get a registered account and post not-spam, because from what I've seen of you so far you have a lot to offer this place and would be a desperately-needed counterweight to the right-wing whackaloon brigade that's running it at the moment.
I am "that girl" your mother warned you about...
(Score: -1, Offtopic) by Anonymous Coward on Wednesday January 29 2020, @01:19AM (12 children)
I was very upfront about posting the Trump info 3 times. As for calling out TMB repeatedly, I will not apologize for that and it had the desired effect of putting attention on his hypocrisy. What method does an AC have of calling attention to something without offtopic posts?
As for an account, no thanks. Maybe if they remove AC posting altogether I would consider it. I also really like seeing my posts survive or not with no identity.
Please clarify what part is the "Aristarchus route."
(Score: 2) by Azuma Hazuki on Wednesday January 29 2020, @02:15AM (6 children)
Look for a poster named Aristarchus, and peruse his journals, especially the ones where he discourses on moral philosophy. Compare that to many of the posts (as he has an account), and see if any AC posts look suspiciously like his posting style.
He has some serious mental firepower and seems to be a decent human being as well, but also tends to troll and shitpost. His "brand" as it were is tarnished, which is a crying tragedy as he could have been a strong weapon against the rising tide of RWNJ insanity. So could you.
I never, ever post AC (I did once accidentally, but replied to it correcting that) and don't troll. I *do* get incredibly confrontational, personal, and profane even by the standards of a native New Yorker, but there is a kind of consistency to it and it helps I'm not exactly in the habit of entering battles of wits unarmed, either. I see serious potential in you, and you could get your posts seen more by default with a registered account. No one says you can't also post AC, and if you're clever about it you can disguise your posting style.
I am "that girl" your mother warned you about...
(Score: -1, Offtopic) by Anonymous Coward on Wednesday January 29 2020, @03:15AM (1 child)
Oh, he's still at it. Forcing me to a VPN for TOR, and he's created a message storage so he can flag posts and prevent me from re-posting.
So I very openly admitted I copy/pasted the trump criticisms from the beginning, and it hardly qualified by this site's standards "Posts so offtopic and lacking value to even be a troll."
At worst I trolled TMB, and since he does that all the time and proudly admits it I don't see why I should be barred from using his tactics. Apparently the freedom of speech around here is "so long as you don't annoy the council." Not to mention that since he updated his journal I have not once repeated the call out. Also I never once copy/pasted the call out, manually typed every one.
That was the purpose of this particular thread, to highlight that he is going above and beyond to punish someone who has stopped the supposed spamming. Any time someone complains about racist garbage TMB says "that is what the moderation system is there for" and let me repeat, not once have I complained about being downmodded.
I do take offense to your characterization of spam, especially given the quality of posts that so frequently inhabit this site. I understand your point of view, but not the vehemence you're heaping on me.
(Score: 1, Offtopic) by Azuma Hazuki on Wednesday January 29 2020, @04:23AM
Believe me, it did *not* escape my notice that there was no formal rule against what you were doing until after-the-fact. Notice how in that snippet from IRC I got right up his beak to clarify exactly what "the same content over and over" would mean, because holy *fuck* would that one ever be abusable if it were "substantially the same ideas" rather than "this is damn near the same post byte-for-byte and in the same order."
The only way to change a system that can't be changed from within is to change it from without. Problem is, I'm not sure how to do that in a way that's legal. Doxxing and blackmail, for example, would work (or just get the place canned on the spot out of fear), but they're not legal and would expose you to significant liability. Ditto hacking, though it would be side-splittingly hilarious if someone were to get into whatever SQL tables held the user accounts and locked certain people out of it! Still, the law's the law; no sense getting jailed for forum drama.
At this point all I could suggest would be popping into #soylent and #editorial to have a word with the saner members of the team, which set I'm sorry to say at this point consists of "MartyB and no one bloody else." Please do get a registered nick, as well. Submit stories (something I should do more often too).
And never, ever back down. Uzzard hates my guts (much as he'll deny it, it's frickin' obvious) because I have absolutely zero filters and will get right in his ugly carrion-molesting face when he fucks up. Maybe trying to change the public opinion here on the forums is a fool's errand, but I suspect #editorial to be a point where skillfully-applied pressure might produce much greater RoI.
I am "that girl" your mother warned you about...
(Score: 0) by Anonymous Coward on Wednesday January 29 2020, @03:22AM (3 children)
Damn, well I had a reply to you Azuma and fucked up posting properly and posted the message to Barbara since I have to copy my writing in the event of invalid form keys or IP ban messages.
The gist was that I used to post thoughtful replies, attempt to provide sources, the whole nine. After years of being shat on by ignoramuses who insist their ignorance is as good as my facts, with a heap of insults on top, I have had enough.
I don't see how my posting is much different than yours, you frequently go on tirades without actually educating the person you're replying to. I do try not to troll, but I no longer have a problem with just calling someone an idiot when I think they are being one. Please give me some quotes of something you consider like Aristarchus' trolling otherwise I have no idea which parts are so reprehensible.
Also, did you catch that this is a new effort at preventing me from posting that I can only assume TMB is coding? I am not repeating my rant for simple attention.
(Score: 2) by Azuma Hazuki on Wednesday January 29 2020, @04:15AM (2 children)
Honestly, there are times I wonder if this site deserves to disappear. It's been taken over by some real dirtbags, and your observation of "...ignoramuses who insist their ignorance is as good as my facts..." is spot-on. It's beyond infuriating; it's actually a powerful inductive argument for certain forms of atheism, in that if there were truly a good, loving, and just God that interfered in human affairs in real time, these peoples' heads would explode.
If I might ask, who were you before? Did you have a named account? And, I don't think what you post is reprehensible, but I do think it runs into the "civility trap" whereby people with no actual morals hide behind "butbut MUH CIVIL DISCOURSE!" and feel justified ignoring or excoriating your content (facts) for its lack of civility (t3h feelz). Ironic, isn't it?
I am "that girl" your mother warned you about...
(Score: 0) by Anonymous Coward on Wednesday January 29 2020, @06:31AM (1 child)
Well as far as horror shows goes this site is probably the best intersection we can hope for between the partisan divide. The real civility trap is in allowing the assholes to laugh their asses off as they push their dumb narratives, it ropes in the human that doesn't have enough knowledge to see through the bullshit.
I was nobody, king of the cowards. Highest upvoted AC around!
(Score: 2) by Azuma Hazuki on Wednesday January 29 2020, @03:35PM
No one says you can't both register an account and post AC.
I am "that girl" your mother warned you about...
(Score: 1) by khallow on Wednesday January 29 2020, @03:01AM (1 child)
(Score: 0, Flamebait) by Anonymous Coward on Wednesday January 29 2020, @03:36AM
As I said to her I'll post with an account when this site bans anonymous posting. What has really stuck in my craw is that this site enforces its own version of a Code of Conduct while the primary admin shits on the very concept. I got banned for posting the links 2-3 times, then once more after the ban as a "fuck you" to that. Possibly upheld because I kept telling TMB to correct his fake news journal.
I've seen so much worse around here that took forever to get TMB to work on, yet here he is trying hard to prevent me from using TOR to continue posting. I have not spammed again, so why is he so motivated to censor me? The hypocrisy after all the whining about FAANG de-platforming conservatives is just too much for me.
This community should take a good look at itself and either follow its own rules better or just admit there is a bias from editors and admins. By the spam descriptions on the site my posts did not qualify. They were trolling at worst, again by the site's standards. I don't recall "series of contracts" guy ever getting a spam ban, he just constantly complained about being down modded.
After the various accusations that have gone around I am calling out the people that run this site. They aren't all bad, but TMB is definitely into abuse of power when he can get away with it.
(Score: 1) by khallow on Wednesday January 29 2020, @04:44AM (2 children)
If it's on topic and original work, you can just post it. If it's off-topic, then there's no method for an AC to call attention. That's by design. We're not a dumping ground.
Get an account, post journals. That's how your off-topic ideas get represented here.
(Score: 0) by Anonymous Coward on Wednesday January 29 2020, @06:36AM (1 child)
Okie dokie free speech warrior! May the racists post forever, but the offtopic "hey look at that important thing" be censored in the name of civility!
May the irony prevent your bolemia for many years to come dear Shallow.
(Score: 1) by khallow on Wednesday January 29 2020, @06:46PM