Molecular 'switch' reverses chronic inflammation and aging:
Chronic inflammation, which results when old age, stress or environmental toxins keep the body's immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer's and Parkinson's to diabetes and cancer.
Now, scientists at the University of California, Berkeley, have identified a molecular "switch" that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.
[...] In the study, Chen and her team show that a bulky collection of immune proteins called the NLRP3 inflammasome -- responsible for sensing potential threats to the body and launching an inflammation response -- can be essentially switched off by removing a small bit of molecular matter in a process called deacetylation.
Overactivation of the NLRP3 inflammasome has been linked to a variety of chronic conditions, including multiple sclerosis, cancer, diabetes and dementia. Chen's results suggest that drugs targeted toward deacetylating, or switching off, this NLRP3 inflammasome might help prevent or treat these conditions and possibly age-related degeneration in general.
"This acetylation can serve as a switch," Chen said. "So, when it is acetylated, this inflammasome is on. When it is deacetylated, the inflammasome is off."
[...] "I think this finding has very important implications in treating major human chronic diseases," Chen said. "It's also a timely question to ask, because in the past year, many promising Alzheimer's disease trials ended in failure. One possible explanation is that treatment starts too late, and it has gone to the point of no return. So, I think it's more urgent than ever to understand the reversibility of aging-related conditions and use that knowledge to aid a drug development for aging-related diseases."
Journal Reference:
Ming He, Hou-Hsien Chiang, Hanzhi Luo, Zhifang Zheng, Qi Qiao, Li Wang, Mingdian Tan, Rika Ohkubo, Wei-Chieh Mu, Shimin Zhao, Hao Wu, Danica Chen. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metabolism, 2020; DOI: 10.1016/j.cmet.2020.01.009
(Score: 2) by jmichaelhudsondotnet on Tuesday February 11 2020, @06:51PM (2 children)
Very long video, 1.4 gb to dl, care to summarize? What are we missing?
btw my mod rights are still not reactivated and at this point I am going to need an explanation.
Thanks
(Score: 2) by FatPhil on Wednesday February 12 2020, @09:56AM (1 child)
[youtube] QRt7LjqJ45k: Downloading webpage
[youtube] QRt7LjqJ45k: Downloading video info webpage
[info] Available formats for QRt7LjqJ45k:
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You're able to download the one that's not 4K resolution, you know?
Doctor, it hurts when I do *this*!
Well, don't do that then.
Your spam-mod case is still under discussion, there are arguments being made both in favour and against revocation of the mod ban.
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 2) by jmichaelhudsondotnet on Wednesday February 12 2020, @08:53PM
Fair enough.
I don't pollute my browser with youtube so i can only blindly download whatever url is on offer.
But this is helpful, thanks Ill check it out on your rec.