Stories
Slash Boxes
Comments

SoylentNews is people

posted by Fnord666 on Tuesday February 11 2020, @01:47PM   Printer-friendly
from the turning-back-the-hands-of-time dept.

Molecular 'switch' reverses chronic inflammation and aging:

Chronic inflammation, which results when old age, stress or environmental toxins keep the body's immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer's and Parkinson's to diabetes and cancer.

Now, scientists at the University of California, Berkeley, have identified a molecular "switch" that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.

[...] In the study, Chen and her team show that a bulky collection of immune proteins called the NLRP3 inflammasome -- responsible for sensing potential threats to the body and launching an inflammation response -- can be essentially switched off by removing a small bit of molecular matter in a process called deacetylation.

Overactivation of the NLRP3 inflammasome has been linked to a variety of chronic conditions, including multiple sclerosis, cancer, diabetes and dementia. Chen's results suggest that drugs targeted toward deacetylating, or switching off, this NLRP3 inflammasome might help prevent or treat these conditions and possibly age-related degeneration in general.

"This acetylation can serve as a switch," Chen said. "So, when it is acetylated, this inflammasome is on. When it is deacetylated, the inflammasome is off."

[...] "I think this finding has very important implications in treating major human chronic diseases," Chen said. "It's also a timely question to ask, because in the past year, many promising Alzheimer's disease trials ended in failure. One possible explanation is that treatment starts too late, and it has gone to the point of no return. So, I think it's more urgent than ever to understand the reversibility of aging-related conditions and use that knowledge to aid a drug development for aging-related diseases."

Journal Reference:
Ming He, Hou-Hsien Chiang, Hanzhi Luo, Zhifang Zheng, Qi Qiao, Li Wang, Mingdian Tan, Rika Ohkubo, Wei-Chieh Mu, Shimin Zhao, Hao Wu, Danica Chen. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metabolism, 2020; DOI: 10.1016/j.cmet.2020.01.009


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: 2) by jmichaelhudsondotnet on Tuesday February 11 2020, @06:51PM (2 children)

    by jmichaelhudsondotnet (8122) on Tuesday February 11 2020, @06:51PM (#956926) Journal

    Very long video, 1.4 gb to dl, care to summarize? What are we missing?

    btw my mod rights are still not reactivated and at this point I am going to need an explanation.

    Thanks

    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2  
  • (Score: 2) by FatPhil on Wednesday February 12 2020, @09:56AM (1 child)

    by FatPhil (863) <pc-soylentNO@SPAMasdf.fi> on Wednesday February 12 2020, @09:56AM (#957150) Homepage
    luser@cubispaz:/usr/local/homes/luser$ youtube-dl -F https://www.youtube.com/watch?v=QRt7LjqJ45k
    [youtube] QRt7LjqJ45k: Downloading webpage
    [youtube] QRt7LjqJ45k: Downloading video info webpage
    [info] Available formats for QRt7LjqJ45k:
    format code extension resolution note
    249 webm audio only tiny 61k , opus @ 50k (48000Hz), 7.91MiB
    250 webm audio only tiny 79k , opus @ 70k (48000Hz), 10.04MiB
    140 m4a audio only tiny 131k , m4a_dash container, mp4a.40.2@128k (44100Hz), 19.59MiB
    251 webm audio only tiny 157k , opus @160k (48000Hz), 19.53MiB
    394 mp4 256x136 144p 82k , av01.0.00M.08, 24fps, video only, 9.40MiB
    160 mp4 256x136 144p 104k , avc1.4d400c, 24fps, video only, 7.80MiB
    278 webm 256x136 144p 106k , webm container, vp9, 24fps, video only, 11.99MiB
    395 mp4 426x224 240p 187k , av01.0.00M.08, 24fps, video only, 17.38MiB
    133 mp4 426x224 240p 227k , avc1.4d400d, 24fps, video only, 14.39MiB
    242 webm 426x224 240p 230k , vp9, 24fps, video only, 19.26MiB
    396 mp4 640x338 360p 359k , av01.0.01M.08, 24fps, video only, 30.94MiB
    243 webm 640x338 360p 492k , vp9, 24fps, video only, 35.20MiB
    134 mp4 640x338 360p 595k , avc1.4d401e, 24fps, video only, 38.98MiB
    397 mp4 854x450 480p 681k , av01.0.04M.08, 24fps, video only, 55.37MiB
    244 webm 854x450 480p 869k , vp9, 24fps, video only, 61.68MiB
    135 mp4 854x450 480p 1144k , avc1.4d401e, 24fps, video only, 77.77MiB
    398 mp4 1280x676 720p 1413k , av01.0.05M.08, 24fps, video only, 114.15MiB
    247 webm 1280x676 720p 1772k , vp9, 24fps, video only, 124.14MiB
    136 mp4 1280x676 720p 2199k , avc1.4d401f, 24fps, video only, 148.83MiB
    399 mp4 1920x1012 1080p 2513k , av01.0.08M.08, 24fps, video only, 200.77MiB
    248 webm 1920x1012 1080p 3762k , vp9, 24fps, video only, 220.34MiB
    137 mp4 1920x1012 1080p 4108k , avc1.640028, 24fps, video only, 269.32MiB
    271 webm 2560x1350 1440p 8426k , vp9, 24fps, video only, 591.77MiB
    313 webm 3840x2026 2160p 16820k , vp9, 24fps, video only, 1.47GiB
    18 mp4 640x338 360p 477k , avc1.42001E, mp4a.40.2@ 96k (44100Hz), 72.17MiB
    22 mp4 1280x676 720p 1112k , avc1.64001F, mp4a.40.2@192k (44100Hz) (best)

    You're able to download the one that's not 4K resolution, you know?

    Doctor, it hurts when I do *this*!
    Well, don't do that then.

    Your spam-mod case is still under discussion, there are arguments being made both in favour and against revocation of the mod ban.
    --
    Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
    • (Score: 2) by jmichaelhudsondotnet on Wednesday February 12 2020, @08:53PM

      by jmichaelhudsondotnet (8122) on Wednesday February 12 2020, @08:53PM (#957386) Journal

      Fair enough.

      I don't pollute my browser with youtube so i can only blindly download whatever url is on offer.

      But this is helpful, thanks Ill check it out on your rec.