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posted by Fnord666 on Monday April 13 2020, @08:39AM   Printer-friendly

What Do the New Remdesivir Data Mean?:

A report has come out in the NEJM on the experience with "compassionate use" (off-label or not yet approved) of the Gilead drug remdesivir in the Covid-19 epidemic. Here are the inclusion criteria:

Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day.

Presented are data from 53 patients in the US, Canada, Europe, and Japan. They were in bad shape – 30 of them were on ventilators and 4 were receiving ECMO treatment (blood oxygenation outside the lungs). At the time of the manuscript's preparation, 25 patients had been discharged from the hospital, and 7 had died (6 of whom had been on ventilation). Overall, clinical improvement was seen in 36 of the 53 patients.

That's pretty much it – those are the numbers we have. The study did not even collect viral-load data, so we can't say what that was like or if it correlated with clinical outcome. What do they tell us? Not much, because this (like so many others early in this epidemic) is not a controlled study. What if you had a list of patients of similar age and gender and pre-existing conditions in similar shape, and didn't give them remdesivir, but just standard-of-care without it? We have just described an appropriate control group, and you can see why you'd want one in order to say anything useful. To be honest, those outcomes sound not unlike what you might expect from treatment without remdesivir, but who knows? Needless to say, you would also want to look at this in a lot more than 53 patients to be sure. It's effect size again: no one expects remdesivir to have miraculous get-up-and-walk effects; what effects it does have are going to be more subtle. And that means you're going to have to have a sufficiently powered (i.e. larger and well-controlled) study to see them.

The authors themselves know this well, of course, and they make no claims. Comparing the 28-day mortality in this study to others, it might be a bit better, but as the paper concludes, "Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy." At the moment it is literally impossible to say.


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  • (Score: -1, Troll) by Anonymous Coward on Monday April 13 2020, @10:14PM (2 children)

    by Anonymous Coward on Monday April 13 2020, @10:14PM (#982260)

    I "apologized" to you TRANNY twisto https://soylentnews.org/comments.pl?cid=937346&sid=35327 [soylentnews.org] ? FUCK NO, not ever: That's NOT me but I DESTROYED YOU PUBLICLY on every level including proving you barb stalk me on THIS SITE https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] with more proof QUOTED FROM YOU DIRECTLY barbara (tom) hudson proving are a technical incompetent brain-damaged transsexual fool BULLSHIT ARTIST FUCKUP worthless creep that also failed on tech vs. me.

    My post LITERALLY also shows links to stopping hundreds of threats of MANY KINDS via hosts (since 99% of malicious threats online use hostnames - block them as I do in hosts (less overhead vs. ANYTHING else by FAR & pure kernelmode TCP/IP stack efficient no less)? Can't TOUCH you nor you it. That's ONLY a 1 year only as a sample and I'd done TONS MORE many hundreds more at slashdot before that and yes 99% use hostnames so hosts work against them harming you).

    So much for your usual lies barb and useless online troll chatterbox you has never done better work and I fairly challenged you to show you did. You have not.

    NOW: You RESORTING TO IMPERSONATING ME on your end only PROVES I really got to you barb/tom hudson tranny.

    So much so you are reduced to showing us your true scum bag self in fact. Thought YOU were going to SUE me? LMAO for what? FACTS ABOUT YOU??? LOL!

    * YOU WILL ALWAYS FAIL vs. me just as you FAILED @ being a MAN & since you couldn't GET ANY PUSSY you (lmao) DECIDED in your DRUG ADDLED BRAIN to SLICE OFF YOUR COCK & build your OWN pussy (only way you'd "get some", ever).... OMG!

    Only thing that "looks like SHIT" is you you FUCKED UP abomination of desolation freak.

    APK

    P.S.=> Hey FREAK? I'm going to PUBLICLY EMBARRASS YOUR ASS SO BAD on this site you will have to SLINK AROUND IN SHAME publicly but then, "your kind" (massive MASSIVE total losers in life) are USED to that, aren't you? You don't LIKE IT but I LOVE doing it, exposing you as the TRASH you are fucker... apk

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  • (Score: -1, Offtopic) by Anonymous Coward on Tuesday April 14 2020, @07:55AM (1 child)

    by Anonymous Coward on Tuesday April 14 2020, @07:55AM (#982454)

    Oh, Dear. Did some one fuch APK up the coacla, again? So sad, abusing the mentally ill like that. Not like he is Runaway, or some other unerudite backwoods squirrel fucking coder, like the TMB. Can we keep this in house, so we do not have to publically deconstruct the apk, again, using the requisite forensic tools? Temporal deviation of the lateral baggus nerve. Overstimulation of the self-importance lobe of the inferior gonad. And the boy is really, really, sick. Stick a fork in him, he's done.

    • (Score: -1, Offtopic) by Anonymous Coward on Tuesday April 14 2020, @05:40PM

      by Anonymous Coward on Tuesday April 14 2020, @05:40PM (#982680)

      I thought it was hilarious how apk showed how completely technically incompetent barbara hudson the big talking blabbermouth tranny is point by point here https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] proving barbara hudson is nothing but a shit brained tranny weirdo asshole. barbara hudson had this coming especially since barb was caught quoted telling others to stalk and harass apk.