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Cosmic Rays May Have Left Indelible Imprint On Early Life, Stanford Physicist Says:

Chirality, also known as handedness, is the existence of mirror-image versions of molecules. Like the left and right hand, two chiral forms of a single molecule reflect each other in shape but don't line up if stacked. In every major biomolecule – amino acids, DNA, RNA – life only uses one form of molecular handedness. If the mirror version of a molecule is substituted for the regular version within a biological system, the system will often malfunction or stop functioning entirely. In the case of DNA, a single wrong handed sugar would disrupt the stable helical structure of the molecule.

Louis Pasteur first discovered this biological homochirality in 1848. Since then, scientists have debated whether the handedness of life was driven by random chance or some unknown deterministic influence. Pasteur hypothesized that, if life is asymmetric, then it may be due to an asymmetry in the fundamental interactions of physics that exist throughout the cosmos.

"We propose that the biological handedness we witness now on Earth is due to evolution amidst magnetically polarized radiation, where a tiny difference in the mutation rate may have promoted the evolution of DNA-based life, rather than its mirror image," said Noémie Globus lead author of the paper and a former Koret Fellow at the Kavli Institute for Particle Astrophysics and Cosmology (KIPAC).

In their paper, published on May 20 in Astrophysical Journal Letters, the researchers detail their argument in favor of cosmic rays as the origin of homochirality.

Cosmic rays are an abundant form of high-energy radiation that originates from various sources throughout the universe, including stars and distant galaxies. After hitting the Earth's atmosphere, cosmic rays eventually degrade into fundamental particles. At ground level, most of the cosmic rays exist only as particles known as muons.

Muons are unstable particles, existing for a mere 2 millionths of a second, but because they travel near the speed of light, they have been detected more than 700 meters below Earth's surface. They are also magnetically polarized, meaning, on average, muons all share the same magnetic orientation. When muons finally decay, they produce electrons with the same magnetic polarization. The researchers believe that the muon's penetrative ability allows it and its daughter electrons to potentially affect chiral molecules on Earth and everywhere else in the universe.

[...] The researchers' hypothesis is that, at the beginning of life on Earth, this constant and consistent radiation affected the evolution of the two mirror life-forms in different ways, helping one ultimately prevail over the other. These tiny differences in mutation rate would have been most significant when life was beginning and the molecules involved were very simple and more fragile. Under these circumstances, the small but persistent chiral influence from cosmic rays could have, over billions of generations of evolution, produced the single biological handedness we see today.

Globus and Blandford suggest experiments that could help prove or disprove their cosmic ray hypothesis. For example, they would like to test how bacteria respond to radiation with different magnetic polarization.

Journal Reference:
Noemie Globus, Roger D. Blandford. The Chiral Puzzle of Life. The Astrophysical Journal, 2020; 895 (1): L11 DOI: 10.3847/2041-8213/ab8dc6

Original Submission