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posted by martyb on Saturday June 13 2020, @09:37AM   Printer-friendly
from the losing-is-winning dept.

Virginia Tech drug researcher develops 'fat burning' molecule that has implications for treatment of obesity (Science Daily)

"Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society," said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.

Santos and his colleagues have recently identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.

The findings, published in Nature Communications on May 14, 2020, hold promise for future treatment and prevention of obesity, diabetes, and especially nonalcoholic steatohepatitis (NASH), a type of fatty liver disease that is characterized by inflammation and fat accumulation in the liver. In the next few years, the condition is expected to become the leading cause of liver transplants in the United States.

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice (open, DOI: 10.1038/s41467-020-16298-2) (DX)

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells (open, DOI: 10.1016/j.apsb.2018.07.010) (DX)

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control (open, DOI: 10.15252/emmm.202012088) (DX)


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  • (Score: 5, Informative) by NickM on Saturday June 13 2020, @02:48PM (1 child)

    by NickM (2867) on Saturday June 13 2020, @02:48PM (#1007443) Journal

    Concentrated fructose is in part responsable, at least according to my doctor.

    Last time I saw him, I told that I was permanently avoiding candy, icecream and the like since the day after I felt like had abused alcohol. His response was that if I had the willpower to do so it was a good thing since concentrated fructose is particularly hard on the liver (like the TFA noted) He then talked to me about a paper he read recently where the researchers were beginning to show¹ that the switch form glucose to concentrated fructose (mostly HFCS) that started mid 80s, early 90s, for purely economical reasons, was in part responsible for the obesity epidemic.

    All that to says that it is not only that there is more energy dense junk food consumed but that most of the junk food available nowadays is objectively more harmful than what was available in the 70s.

    1- the conclusion was the archetypal: more studies are needed (read we need more money and want to continue to do the same thing we are doing)

    --
    I a master of typographic, grammatical and miscellaneous errors !
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  • (Score: 0) by Anonymous Coward on Saturday June 13 2020, @04:30PM

    by Anonymous Coward on Saturday June 13 2020, @04:30PM (#1007470)

    From 2009 the effects of sugar on society including the physiological effects on the human body:

    https://www.youtube.com/watch?v=dBnniua6-oM [youtube.com]

    The effects of artificial sweeteners on insulin production: https://www.webmd.com/diet/news/20140917/artificial-sweeteners-blood-sugar#1 [webmd.com]
    The role of insulin on fat production (and fat loss suppression): https://www.healthline.com/nutrition/9-fixes-for-weight-hormones#section1 [healthline.com]

    Conclusions for me confirmed by experimentation:

    1) Consume fructose and I will gain weight.
    2) Avoid fructose but consume artificial sweeteners and I won't gain weight, but I won't lose weight either.
    3) Avoid fructose and artificial sweeteners as much as possible and I will lose weight.