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Virginia Tech drug researcher develops 'fat burning' molecule that has implications for treatment of obesity (Science Daily)
"Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society," said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.
Santos and his colleagues have recently identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.
The findings, published in Nature Communications on May 14, 2020, hold promise for future treatment and prevention of obesity, diabetes, and especially nonalcoholic steatohepatitis (NASH), a type of fatty liver disease that is characterized by inflammation and fat accumulation in the liver. In the next few years, the condition is expected to become the leading cause of liver transplants in the United States.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice (open, DOI: 10.1038/s41467-020-16298-2) (DX)
Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells (open, DOI: 10.1016/j.apsb.2018.07.010) (DX)
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control (open, DOI: 10.15252/emmm.202012088) (DX)
(Score: 1, Funny) by Anonymous Coward on Saturday June 13 2020, @06:31PM (1 child)
"If this stuff worked, I'd use it like salt in a shaker on every meal."
I don't think the FDA would approve anything that can't kill you. I hear that in order for anything to get FDA approved you have to be able to overdose and die from it. They have to know what dose will kill a mouse in an experiment. If your experiment resulted in no deaths they won't approve it even if it cured them of many/all health problems.
Since good diet is not something that can kill a mouse (when compared to a bad diet) it can't possibly be FDA approved to treat anything.
(Score: 0) by Anonymous Coward on Saturday June 13 2020, @06:44PM
I think that also applies to things like herbs and whatnot. The FDA won't approve it if you can't provide what a lethal dose is and if it's pretty harmless and doesn't hurt any mouse subjects yet miraculously cures many ailments the FDA still won't approve it.
and if it's something new the FDA can prevent it from reaching market or remove it from the market (the DSHEA restricts the FDA from removing products from the market if they have been on the market for so long but new products they can still remove). So this miracle cure, if it's harmless, will never see the light of day.