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Virginia Tech drug researcher develops 'fat burning' molecule that has implications for treatment of obesity (Science Daily)
"Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society," said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.
Santos and his colleagues have recently identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.
The findings, published in Nature Communications on May 14, 2020, hold promise for future treatment and prevention of obesity, diabetes, and especially nonalcoholic steatohepatitis (NASH), a type of fatty liver disease that is characterized by inflammation and fat accumulation in the liver. In the next few years, the condition is expected to become the leading cause of liver transplants in the United States.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice (open, DOI: 10.1038/s41467-020-16298-2) (DX)
Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells (open, DOI: 10.1016/j.apsb.2018.07.010) (DX)
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control (open, DOI: 10.15252/emmm.202012088) (DX)
(Score: 0) by Anonymous Coward on Saturday June 13 2020, @06:38PM (1 child)
Weight loss is hard because it also takes willpower. My wife has currently lost over 30 pounds in the past 9 months on a diet plan set out by a nutritionist. 0-2 pounds every week usually.
Everyone asks her 'how? what pills did you take'. Every last one. She then tells them it is 'diet and exercise none of the pills work, I tried them'. 'oh never mind'. *NO* one wants to do the work but wants all the reward easily. The problem with 'studies' like this is that it gives out false hope to people and make them think that it is easy. Easy is giving into your 'want' and hard is following the plan. I am sure some snake oil salesman will have something that does this by the end of the month wrapped up in a slick website. Selling pills at 60 dollars a bottle that do nothing.
With this study has it been tried on humans or just mice so far? Because usually that is where that fails in some way and we never hear about it again.
(Score: 0) by Anonymous Coward on Saturday June 13 2020, @10:04PM
I posted upthread as AC - long term success rates for diets are not encouraging. I've lost more than 20 pounds five different times in my life, and gained it back each time. Every time, I planned to make the exercise and dietary changes permanent. There are millions of people who lose a ton of weight and keep it off five years or longer, but for every one of them there are three or more other people that lost a ton of weight and then gained it back. I wish your wife all the luck in the world - but tell me how her weight is in five years, or ten, or twenty.
Read the research on fat loss sustainability. The stats are awful.