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Parkinson's is the second most common neurodegenerative disorder after Alzheimer's disease. 500,000 individuals in the United States have been diagnosed with Parkinson's disease, and many with the disease are undiagnosed, according to the National Institute of Neurological Disorders and Stroke. Most who have Parkinson's are diagnosed after age 60. There are no drugs known to prevent the disease, but there are a growing number of treatments to relieve symptoms.
[...] The study, which enrolled 2,930 men with an average age of 76.3 when the research began, was part of the larger, population-based Osteoporotic Fractures in Men Study (MRoS), which began in 2000 and enrolled men at six medical centers nationwide. None of the participants in the subset of the MRoS cohort initially had Parkinson's, and all were living in community-based settings (i.e. not in nursing homes). Their status for many health-related factors was assessed at the start, and they were monitored through follow-up visits and questionnaires.
As part of the study, researchers monitored circadian rhythms of rest and activity over three separate 24-hour periods by having participants wear an actigraph -- a watch-like device that detects and records even slight wrist movements. The data collected from these devices were independently associated with the later development of Parkinson's.
In a previous study, Leng and Yaffe identified an association between daytime napping and the later development of Parkinson's. But the link between circadian rhythms and Parkinson's is not just a matter or disrupted sleep, according to the new study. The association held true even after accounting for indicators of sleep disturbances -- including loss of sleep; sleep inefficiency (time spent asleep after turning off the lights); leg movement during sleep; and the chronic, temporary cessation of breathing known as sleep apnea.
Journal Reference:
Yue Leng, Kristine Yaffe, Terri Blackwell, et al. Association of Circadian Abnormalities in Older Adults With an Increased Risk of Parkinson Disease, JAMA Neurology (DOI: 10.1001/jamaneurol.2020.1623)
(Score: 2) by sjames on Sunday June 21 2020, @09:36PM (2 children)
It couldn't hurt to check. Is this a life-long thing or a recent development (just curious).
(Score: 5, Interesting) by TheReaperD on Sunday June 21 2020, @10:17PM (1 child)
Serious symptoms started 15 years ago. But, going through my past with my doctor, we found multiple signs of it affecting me since childhood. Adults just dismissed it as 'growing pains.' Doctor confirmed my issues were very abnormal. This has since been confirmed by two more doctors. It has some similarities to fibromyalgia, but is far more severe. The pain alone is sometime enough to drop me to the ground or knock me unconscious. Lyrica and opioids only take the edge off. It would fit MS, but that has been positively eliminated both 10 years ago and again last year. Both MRI and CT scans have come up clean. I ceiling out an EEG, but anti-seizure medication has proven worthless. The only thing that has worked short term was Topamax, but I quickly became resistant within weeks and outright rejected it within two months. Not to mention, the side effects were hell (but, I would have lived with them). The only other things that have proven to help have been MDMA and Ketamine, both of which cannot be used therapeutically.
Ad eundum quo nemo ante iit
(Score: 0) by Anonymous Coward on Monday June 22 2020, @08:03PM
I'm quite sure I know what you mean, but just to be sure: this means you can't discuss them with your doctor, right?