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Age-related impairments reversed in animal model (SD)
Frailty and immune decline are two main features of old age. Researchers from the University of Bern and the University Hospital Bern now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.
[...] The team around Dr. Noti and Dr. Eggel could demonstrated that a certain kind of immune cells, known as eosinophils, which are predominantly found in the blood circulation, are also present in belly fat of both humans and mice. Although classically known to provide protection from parasite infection and to promote allergic airway disease, eosinophils located in belly fat are responsible to maintain local immune homeostasis. With increasing age the frequency of eosinophils in belly fat declines, while the number of pro-inflammatory macrophages increases. Owing to this immune cell dysbalance, belly fat turns into a source of pro-inflammatory mediators accumulating systemically in old age.
In a next step, the researchers investigated the possibility to reverse age-related impairments by restoring the immune cell balance in visceral adipose tissue. "In different experimental approaches, we were able to show that transfers of eosinophils from young mice into aged recipients resolved not only local but also systemic low-grade inflammation", says Dr. Eggel. "In these experiments, we observed that transferred eosinophils were selectively homing into adipose tissue", adds Dr. Noti. This approach had a rejuvenating effect on the aged organism. As a consequence, aged animals showed significant improvements in physical fitness as assessed by endurance and grip strength tests. Moreover, the therapy had a rejuvenating effect on the immune system manifesting in improved vaccination responses of aged mice.
They managed to work COVID-19 into the press release.
Journal References:
Daniel Brigger, Carsten Riether, Robin van Brummelen, et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age, Nature Metabolism (DOI: 10.1038/s42255-020-0228-3)
Chih-Hao Lee. Young eosinophils rejuvenate ageing adipose tissues, Nature Metabolism (DOI: 10.1038/s42255-020-0230-9)
(Score: 3, Insightful) by aristarchus on Friday July 10 2020, @02:25AM (6 children)
Another post from out resident "thanatophobic". Take it from me, not dying has it's down sides. One is you have to put up with all the abuse for uneducated and inexperienced neophytes. The other is that more and more defecation becomes the highpoint of your day. But if you have to resort to Young Blood vampirism like Peter Thiel, then it is unearned (or, uncursed? The problem is that if the curse is put on you, through no fault of your own, then no harm, no foul. But if you call it down upon yourself by sacrificing the younglings just so you can hang on to your miserable existence, well, then. . . ) and so life-extension is a liability. Grandpa: One thing about living in
Santa CarlaSilicon Valley I never could stomach,all the damn vampires. [rottentomatoes.com](Score: 0) by Anonymous Coward on Friday July 10 2020, @02:30AM
I'm waiting for some dumbfuck idiot that reads this and starts going zombie on somebody's belly fat.
(Score: 1) by Sulla on Friday July 10 2020, @02:44AM (1 child)
Speak for yourself Greekoid, you Eastern-types always were melodramatic.
Ceterum censeo Sinae esse delendam
(Score: 2) by aristarchus on Friday July 10 2020, @02:51AM
And you Romans, what with the "falling on your sword", the fratricides, the incest, and the Imperium? Best not to pitch lithia, in praesentia cum domo speculo.
(Score: 2, Informative) by aristarchus on Friday July 10 2020, @04:27AM (2 children)
See?
Has modded me troll. I do not mind. I am not offended, in the slightest. But just remember, mostly likely, when you are mouldering in the filth of ages, I will still be posting in the SoylentNews of the future.
(Score: 2) by DannyB on Friday July 10 2020, @04:20PM (1 child)
Welcome to hell. There is some good news, and some bad news.
First the good news. You can get Usenet in hell!
The bad news is that there is only one news group: comp.news.sci.red.soc.talk.misc.
To transfer files: right-click on file, pick Copy. Unplug mouse, plug mouse into other computer. Right-click, paste.
(Score: 5, Funny) by turgid on Friday July 10 2020, @10:00PM
Many years ago, a Young Conservative told me the following joke.
A man dies suddenly and finds himself in Hell. He is distraught. While he is moping, another man sidles up to him. "What's the matter?" he enquires sympathetically?
"I've... gone to the wrong place," comes the snivelling reply.
"Oh, it's not so bad," says the other. "Do you smoke?"
"Yes, I do."
"Oh well, then," comes the consolatory reply, "You'll like Mondays. On Mondays, we smoke all day long, And do you drink?"
"Yes, I like a tipple now and then."
"Excellent. You'll be very happy on Tuesdays. We drink all day long. Gambling?"
"I do enjoy the odd game of cards, and a flutter on the gee-gees,"
"Wonderful! On Wednesdays, from dawn to dusk we gamble non-stop. Are you gay, by any chance?"
"No."
"Ah, you won't like Thursdays then..."
I refuse to engage in a battle of wits with an unarmed opponent [wikipedia.org].