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posted by martyb on Friday July 10 2020, @01:04AM   Printer-friendly

Age-related impairments reversed in animal model (SD)

Frailty and immune decline are two main features of old age. Researchers from the University of Bern and the University Hospital Bern now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.

[...] The team around Dr. Noti and Dr. Eggel could demonstrated that a certain kind of immune cells, known as eosinophils, which are predominantly found in the blood circulation, are also present in belly fat of both humans and mice. Although classically known to provide protection from parasite infection and to promote allergic airway disease, eosinophils located in belly fat are responsible to maintain local immune homeostasis. With increasing age the frequency of eosinophils in belly fat declines, while the number of pro-inflammatory macrophages increases. Owing to this immune cell dysbalance, belly fat turns into a source of pro-inflammatory mediators accumulating systemically in old age.

In a next step, the researchers investigated the possibility to reverse age-related impairments by restoring the immune cell balance in visceral adipose tissue. "In different experimental approaches, we were able to show that transfers of eosinophils from young mice into aged recipients resolved not only local but also systemic low-grade inflammation", says Dr. Eggel. "In these experiments, we observed that transferred eosinophils were selectively homing into adipose tissue", adds Dr. Noti. This approach had a rejuvenating effect on the aged organism. As a consequence, aged animals showed significant improvements in physical fitness as assessed by endurance and grip strength tests. Moreover, the therapy had a rejuvenating effect on the immune system manifesting in improved vaccination responses of aged mice.

They managed to work COVID-19 into the press release.

Journal References:
Daniel Brigger, Carsten Riether, Robin van Brummelen, et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age, Nature Metabolism (DOI: 10.1038/s42255-020-0228-3)

Chih-Hao Lee. Young eosinophils rejuvenate ageing adipose tissues, Nature Metabolism (DOI: 10.1038/s42255-020-0230-9)


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  • (Score: 0) by Anonymous Coward on Friday July 10 2020, @05:37AM

    by Anonymous Coward on Friday July 10 2020, @05:37AM (#1018972)

    Or you know, instead of buying this new transfusion subscription they're developing you could lose the belly fat so there's nothing to trigger the inflammation in the first place.

    This is an example of people seeing what they expect to see. "Frailty and immune decline are two main features of old age" No! Even in the summary it says further down they demonstrate it's the increasing inflammation that's the cause, not old age. Curing the inflammation doesn't make you stop aging. It stops the slow, on-going damage to your body. Being old doesn't mean you're inherently frail and in poor health. Age is not the issue, inflammation is the issue and you can solve that without their solution. People who are sick for a long time look sick. Those frail old guys are frail because they been sick for so long not because they're old.