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upstart writes in with an IRC submission for RandomFactor:

https://medicine.uiowa.edu/content/study-pinpoints-brain-cells-trigger-sugar-cravings-and-consumption:

Most people enjoy a sweet treat every now and then. But an unchecked “sweet tooth” can lead to overconsumption of sugary foods and chronic health issues like obesity and type 2 diabetes. Understanding the biological mechanisms that control sugar intake and preference for sweet taste could have important implications for managing and preventing these health problems.

The new study, led by Matthew Potthoff, PhD, associate professor of neuroscience and pharmacology in the University of Iowa Carver College of Medicine, and Matthew Gillum, PhD, at the University of Copenhagen in Denmark, focuses on actions of a hormone called fibroblast growth factor 21 (FGF21). This hormone is known to play a role in energy balance, body weight control, and insulin sensitivity.

[...] Potthoff and his colleagues previously discovered that FGF21 is made in the liver in response to increased levels of sugar, and acts in the brain to suppress sugar intake and the preference for sweet taste.

[...] Although it was known that FGF21 acted in the brain, identifying the exact cellular targets was complicated by the fact that the hormone’s receptor is expressed at very low levels and is therefore difficult to “see.” Using various techniques, the researchers were able to precisely identify which cells express the receptor for FGF21. By investigating these cells, the study shows that FGF21 targets glutamatergic neurons in the brain to lower sugar intake and sweet taste preference. The researchers also showed that FGF21’s action on specific neurons in the ventromedial hypothalamus reduce sugar intake by enhancing the neurons’ sensitivity to glucose.

Journal Reference:
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake, Cell Metabolism (DOI: 10.1016/j.cmet.2020.06.008)

Original Submission