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When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the process begins, which may provide new insight into wound healing, fibrosis and cancer metastasis.
"Clinical efforts to prevent the progression of fibrocontractile diseases, such as scarring and fibrosis, have been largely unsuccessful, in part because the mechanisms that cells use to interact with the protein fibers around them are unclear," [Delaram] Shakiba said. "We found that fibroblasts use completely different mechanisms in the early -- and I think the most treatable -- stages of these interactions, and that their responses to drugs can therefore be the opposite of what they would be in the later stages."
[...] The researchers learned they could control the cell shape in two ways: First, by controlling the boundaries around it, and second, by inhibiting or upregulating particular proteins involved in the remodeling of the collagen.
Fibroblasts pull the edges of a wound together, causing it to contract or close up. Collagen in the cells then remodels the extracellular matrix to fully close the wound. This is where mechanobiology comes into play.
"There's a balance between tension and compression inside a cell that is newly exposed to fibrous proteins," [professor Guy] Genin said. "There is tension in actin cables, and by playing with that balance, we can make these protrusions grow extremely long," Genin said. "We can stop the remodeling from occurring or we can increase it."
Journal Reference:
Delaram Shakiba, Farid Alisafaei, Alireza Savadipour, et al. The Balance between Actomyosin Contractility and Microtubule Polymerization Regulates Hierarchical Protrusions That Govern Efficient Fibroblast–Collagen Interactions, ACS Nano (DOI: 10.1021/acsnano.9b09941)
(Score: -1, Spam) by Anonymous Coward on Saturday August 01 2020, @12:45PM
Marissa Van Eck FAKENAME CUNT Azuma Hazuki: So "that was NOT me posting" https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=985641#commentwrap [soylentnews.org] which YES, you said when you LIBELED me publicly BEFORE it with YOU saying "So that's a "yes" to schizophrenia/schizoaffective disorder and a "no" to "am taking meds for said disorder" LIBELING ME then...?" per YOUR https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=982854#commentwrap [soylentnews.org] you stupid pitiful FAKENAME fuck online LIAR piece of fucking SHIT?
OR
Was it when I GOT YOUR REAL NAME & found you are a satanist/anti-god HERE https://redeeminggod.com/sermons/luke/luke_7_36-50/#comment-269796 [redeeminggod.com] also which most ALL you "LEFTIST" LOSER weirdos usually are (which YES, in THIS other exchange "Why do you assume that you finding discussion threads on other sites with me in them will scare me?" quoted from https://soylentnews.org/comments.pl?noupdate=1&sid=38720&page=1&cid=1028402#commentwrap [soylentnews.org] you DID admit FINALLY to saying it was you - ESPECIALLY AFTER dozens of doctors RECENTLY seconded me on Hydroxychloroquin + Zinc (& Vitamin D3 imo along w/ other things I noted that are anti-viral + antibacterial like RAW GARLIC too)).
Do me a favor - DENY ANY OF THOSE, please & I will continue PROVING YOU ARE A SHITBAG LOSER, devil... as I already DID here https://soylentnews.org/comments.pl?noupdate=1&sid=38720&page=1&cid=1028211#commentwrap [soylentnews.org]
The TRUE BEAUTY of SATANIST FUCKS like YOU (antigod assholes)? TRUTH & FACT DESTROYS LIBELOUS DEVILS LIKE YOU - just like I did you & OTHER AHOLES who doubted what I wrote on what is NOW PROVEN TRUE by DOCTORS, admitted in mainstream media etc. (as I showed in those links' exchanges above easily) & especially LATELY by DOZENS of doctors (I have proof from pros - NOT LIBEL like you did to me PUBLICLY & I can still FRY YOU FOR IT FUCKER, live in fear fuck) MINUS any psych pros backing you.
SAY 1 THING, YOU STINKING LIBELOUS FUCK & I will CONTINUE LEVELLING YOU PUBLICLY with facts - not libel as you tried on me, stupid "Marissa von DUMBO", lol - please, say 1 thing & the BEATING on you, PUBLICLY will continue in this thread where you will have a HELL of a TIME "downmod burying it" via downmod brigades doubtless ONLY yourself via multiple sockpuppet accounts etc. (downodding to HIDE it? FORGET IT vs. me - everyone sees you @ it now, lol - thanks, just as I SAID "your kind", demonic SWINE/antigod LOSERS, always do).
WHY SHOULD YOU FEAR LIBELING ME PROJECTING IT NOW, TRYING TO HIDE IT TOO?
TOUGH HIDING YOU LIED about LIBELING ME, especially via INHERENTLY DAMAGING STATEMENTS libeling me as you did see GOLDWATER RULE below too fuckface CUNT you are (wikipedia proof https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=985366#commentwrap [soylentnews.org] & you said "No jury or judge would back it" here https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=985353#commentwrap? [soylentnews.org] Ok - like I said earlier here which you TRIED TO DOWNMOD HIDE as I knew you HAVE to (everyone sees it anyhow) - TRY ME FUCKER - say 1 thing you COWARDLY STUPID LITTLE FUCK & we'll SEE what happens to you, fuckface CUNT you are).
As I said "DO YOU WANT TO BE SUED" for breaking the GOLDWATER RULE? See here again https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=985329#commentwrap [soylentnews.org] for YOUR (& everyone else's) reference of YOUR LIBEL of myself
APK
P.S.=> Oh, I am going to have a FIELDDAY on YOUR ASS fucker - catching you not ONLY IN LIES above, but also in the fact you are a GODLESS fucking LOSER - come on, say something, question the above where you LIED fucker ("it was not me saying it" but it WAS in those links calling me a nutcase essentially when YOU SAID YOU DID NOT (because it IS grounds for SUING THE LIFE OUT OF YOUR WORTHLESS ASS because your statements are NOT BACKED BY actual psychiatric pros in professional psychiatric grounds LIBELING ME)) - oh, you are NEVER going to LIVE THIS DOWN & believe you me - I am going to MAKE SURE you don't - live with your HUMILIATION loser... apk