As with many aspects of the new coronavirus, researchers are trying to pull together data to understand the medium-term health effects more fully.
[...] Its impact on the heart still isn't clear, Dr Gallo says, but studies published in recent weeks describe abnormalities in the hearts of patients who have completely cleared the virus.
"[The researchers] asked them about their just general wellbeing and a lot of the patients are commenting on just being generally exhausted and having shortness of breath, some of them having palpitations, atypical chest pain," she says.
What's more, many of these patients weren't that sick with COVID-19 — most of them had managed their illness at home, rather than needing hospital treatment.
[...] Other persistent symptoms people report have to do with the brain: "brain fog", sleeplessness and headaches.'
[...]Fatigue, which is more than just a feeling of tiredness, and can be associated with things like a "foggy" brain, slowed reflexes and headaches, is usually a useful response to infections.
"There's a good reason for that — mounting an immune response to fight an infection takes a huge amount of energy," Dr Landowski says.
"The body wants you to do as little as possible, so you can conserve energy and divert it to the immune system.
Then, once the infection is eliminated, the fatigue dissipates.
"However, in some people, the switch that returns the body back to normal seems to fail, resulting in chronic fatigue."
[...] "Regardless of which cells it's infecting, if it's infecting cells in the brain, it could be causing damage, which could have long-term consequences," Dr Lawson said.
Even if the virus doesn't infect brain cells directly, inflammation caused by the virus could also cause damage to the brain.
Some experts are concerned the medium-term effects on the brain might have consequences that reach further.
In an article in the Journal of Alzheimers Disease Reports, experts raise the question of whether people who've had COVID-19, particularly those whose symptoms included loss of taste or smell, will be at greater risk of conditions including Alzheimer's disease after they recover.
The last-linked article from above (which is open-access), is excerpted here with links sprinkled on some of the unusual terms:
Some of the earliest neurologic findings were in those experiencing COVID-19-related anosmia and dysgeusia [2]. Important to this equation is that COVID-19 may prove to be a risk factor for future neurodegenerative disorders, beyond that which would be expected in the context of other comorbidities and genetic predispositions. Anosmia and the biological processes resulting in this symptom contribute to grey matter loss in cortical regions [3], which is similar to where pathognomonic amyloid plaques are often discovered [4]. Olfactory dysfunction has also been found to be associated with the graduation from mild cognitive impairment (MCI) to AD, serving as a potential identifier for preclinical stages [5].
[...] It has become clear that many age-related conditions are found among those testing positive for COVID-19, though some of these are also related to lifestyle and family history. ... Systolic hypertension in midlife, rather than only late life, is associated with 18% and 25% increased risk of AD, respectively ... These cardiovascular risk factors are directly related to cerebrovascular consequences, such as hypoperfusion, a symptom strongly associated with MCI and AD [14]. Plasma exchange and albumin for AD patients with hypoperfusion, for example, has been shown to improve cognitive deficits and initiate cerebrospinal fluid (CSF) amyloid-β (Aβ)...
Journal Reference:
Jack C. Lennon. Neurologic and Immunologic Complications of COVID-19: Potential Long-Term Risk Factors for AlzheimerΓÇÖs Disease [open], Journal of Alzheimer's Disease Reports (DOI: 10.3233/ADR-200190)
Got it! The millennials surviving COVID-19 today may have higher chances of an early onset of dementia than the baby boomers of today.
(Score: 2, Insightful) by Anonymous Coward on Monday August 03 2020, @10:12AM (19 children)
I'm sorry, but most "western" countries are doing fine. The US fucked up bad for some reason, but Canada and the EU are currently doing as well as can be expected as far as the disease is concerned. Yes, some countries in the EU are still having trouble, but most of the EU population is reasonably safe at the moment.
by the way, I'm confused about what you mean by "western". I assume you mean Canada, USA, and the EEA countries.
(Score: 3, Interesting) by Opportunist on Monday August 03 2020, @10:52AM (3 children)
Because it seems that our political systems are still doing what they are supposed to. Yes, our parties are bickering usually and our populists are screaming their paroles, but suddenly as soon as this shit hit the fan, even they stopped and became sensible instead of spreading bullshit for petty political gains. And it seems that the people around here don't get their medical information from celebrities (usually celebrities where you wonder what they're famous for, or can someone explain to me what the Kardashians do?) but instead turn to medical professionals for that kind of advice, and fortunately not to quacks with a political agenda but rather their GP they usually trust with their health, who in turn has every incentive to give them a sensible treatment instead of peddling some miracle cure.
Our politicians still retained a modicum of trust in the population, mostly because we do see how they react to our concerns. They tell us what they're going to do and they are going to do it. No empty promises. Yes, people lost jobs here, too, and yes, businesses were struck badly here, too, but governments opened their money bags and ensured that people and small businesses could survive rather than shoving it up the ass of their cronies and "hope" it somehow trickles down instead of vanishing in the pockets of the CEOs.
People here have a reason to expect their government to work for them. People in the US have a reason to expect their government to screw them over.
That is the difference.
(Score: 3, Insightful) by hendrikboom on Monday August 03 2020, @01:18PM (2 children)
Where is your "here"?
(Score: 2) by Opportunist on Monday August 03 2020, @07:31PM (1 child)
Right now, for me Austria. 9 million people, got hit early in March at pretty much the same time and with the same intensity as Italy (with the same reason, being a huge, high profile holiday resort where the local authorities tried to keep it under wrap 'til they got smacked left and right by the country's government, despite being the same party). A total of 2,360 cases per million, 80 deaths per million. Most of both of them during March and April. Currently 1,600 active cases (177 per million) with a 7 day running death rate flickering between 0 and 1 (hard to make a sensible statement about it, since peopel can't half-die) and about 100-120 new cases per day (yeah, it picked up quite a bit again when the restrictions were lifted), which amounts to 13 new cases per million and is about on par with recoveries per day.
(Score: 2) by hendrikboom on Thursday August 06 2020, @06:34PM
Thanks for the details. Too many people say "here" when no one knows where they are except themselves.
I thought you might have been talking about Quebec, where I live.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @02:35PM (14 children)
I'd add that some parts of the US are doing much better than others. Mostly the Northeast, because we got hit early (because of wide use of public transport and high population density) and saw the carnage that ensued.
As such, while it's not everyone, *most* people are being really careful -- wearing masks, staying at least 2m away from others, and not gathering in groups *indoors*.
The areas where we see low infection rates right now have large numbers of folks who see that we need to work together, protecting each other, not whinging about "muh rights!" and "gub'mint overreach!"
No one can force you to care about your neighbors and fellow Americans. But like it or not, we share this country. And if we want to get this virus under control, we need to work together as Americans. For all of us.
It makes me sad that many people only see it as "fuck you Jack! I'm all right," even though that will just extend and worsen this pandemic.
More's the pity.
(Score: -1, Redundant) by Anonymous Coward on Monday August 03 2020, @03:36PM (13 children)
Most people in the northeast are already immune. That is why it spreads slowly there now. Like 30-80% of people have pre existing t cell immunity, so only 10-20% of the population gets covid before herd immunity sets in.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @04:46PM (1 child)
I'd say more like 10-90% ballpark.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @05:01PM
Depends where you live.
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity [sciencemag.org]
https://www.researchsquare.com/article/rs-35331/v1%20 [researchsquare.com]
Why are there so many anti-science retards on this site?
(Score: 0) by Anonymous Coward on Monday August 03 2020, @05:47PM (10 children)
And where did you get those numbers? AFAIK, *Antibody* testing isn't being done on any wide scale, nor is the much more involved (and accurate) T-Cell testing.
The tests being done are viral tests to see if you are infected *right now*. And, just like the rest of the US, it's taking way too long to get results back. In some cases, 7-14 days. Which is, of course, worse than useless.
So I ask again, where do you get these numbers to claim that 30-80% are immune? Other than from your rectal cavity?
Please, do tell.
(Score: 0, Disagree) by Anonymous Coward on Monday August 03 2020, @05:55PM (9 children)
The refs were posted here:
https://soylentnews.org/comments.pl?noupdate=1&sid=38801&commentsort=0&mode=threadtos&threshold=-1&highlightthresh=-1&page=1&cid=1030791#commentwrap [soylentnews.org]
Also, there are cross-reactive antibodies found in 5-10% of adults and much higher (up to 60%) of school children:
https://www.biorxiv.org/content/10.1101/2020.05.14.095414v2 [biorxiv.org]
If all these lockdowns and other measures continue for long enough all this immunity is going away and the problem will be 2-5x worse than it was in April.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @06:31PM (8 children)
Except the references linked don't say what you think they do.
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity [sciencemag.org]
https://www.researchsquare.com/article/rs-35331/v1 [researchsquare.com]
What was that you were saying? Nothing useful or important.
kthxbai.
(Score: -1, Redundant) by Anonymous Coward on Monday August 03 2020, @06:52PM (7 children)
So now t-cell immunity doesnt confer protection either? Just like the WHO tweeted about antibodies... What is the point of it if not to confer protection like for every other virus?
Also, no idea what the second quote is supposed to prove. Can you clarify what you think it says?
(Score: 0) by Anonymous Coward on Monday August 03 2020, @07:12PM (6 children)
Your semi-literacy is not my problem. It's yours.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @07:24PM (5 children)
Well you quoted something that says the cross reactive t-cells originally raised towards cold viruses are important for proper immune response. So, I guess you agree with me then...
(Score: 0) by Anonymous Coward on Monday August 03 2020, @07:52PM (4 children)
English, motherfucker. Can you read it? Apparently not.
Your ignorance is stunning. Get a clue. If you can. I won't hold my breath.
(Score: -1, Troll) by Anonymous Coward on Monday August 03 2020, @08:14PM (3 children)
"Rather, diversity of T-cell responses in terms of recognition rate of SARS-CoV-2 T-cell epitopes was decreased in patients with more severe COVID-19 symptoms (Fig. 4h, Extended Data Fig. 4b), providing evidence that development of protective immunity requires recognition of multiple SARS- CoV-2 epitopes."
Whatever, you apparently have no idea what those words you quoted mean. I hope for your sake you are trolling instead of being profoundly stupid.
(Score: 0) by Anonymous Coward on Monday August 03 2020, @11:57PM (2 children)
This means that while SARS COV2 *may* share epitopes [britannica.com] with other Coronaviruses, antibodies must be able to identify/connect to multiple epitopes, some that are unique to SARS COV2 in order to convey significant levels of immunity. Which fully supports what I said. Which is why I quoted it in the first place.
You're a troll and/or a moron. Don't care which. No more feeding for you, asshole. Get back under your bridge!
(Score: -1, Troll) by Anonymous Coward on Tuesday August 04 2020, @12:30AM
It means if you had prior immunity to other coronaviruses that cross react with sars2, then you have "diversity of T-cell responses", which is evidence for "protective immunity".
So no, that is not what you said.
(Score: -1, Troll) by Anonymous Coward on Tuesday August 04 2020, @12:33AM
Also it was about t-cells, not even about antibodies. It is so obvious you have no idea what you read.