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"Reelin" in a new treatment for multiple sclerosis:
In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease's characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.
[...] In 1997, researchers discovered a protein secreted in the brain called Reelin. Subsequent work showed that Reelin appears to help the brain organize itself during development and assist in forming connections between brain cells during adulthood. However, as researchers learned more about Reelin, they discovered that large amounts of it are produced in the liver and that cells lining blood vessels have receptors for this protein.
[...] Herz, Calvier, and their colleagues worked with mice affected by a disease called experimental autoimmune encephalomyelitis (EAE), a condition that mimics human MS. When these animals were genetically modified so that the researchers could control Reelin production, they found that eliminating this protein substantially mitigated the disease's typical paralysis or even eliminated it altogether, in contrast to mice with normal Reelin levels. These effects appeared to stem from the lack of monocyte adhesion on the altered animals' blood vessel walls, which prevented entry into the central nervous system.
A potential new treatment for MS sufferers?
[Ed Note - "Calvier and Herz are shareholders of Reelin Therapeutics Inc. of La Jolla, California, along with co-author Maria Z. Kounnas, Ph.D., who is affiliated with Reelin Therapeutics. Calvier and Herz are co-inventors of a patent related to anti-Reelin strategies (application number 15/763,047 (patent pending) and publication number 20180273637). "]
(Score: 1, Flamebait) by ChrisMaple on Friday August 14 2020, @05:24AM (10 children)
At a cost of hundreds of thousands of dollars and years of our lives, we've just developed a cure for a cause of terrible human suffering. As our proper reward, let's give it away for free, and live our lives in obscurity and poverty.
That's what you're implying they should do. With ideas like that, it's amazing that most of humanity isn't still living in mud huts.
(Score: 3, Informative) by Anonymous Coward on Friday August 14 2020, @05:34AM (9 children)
Dr. Jonas Salk, and Hippocrates want a word with you, mercenary drug dealer. Are still in prison for you last "investment opportunity", Pharma Bro?
(Score: 0) by Anonymous Coward on Friday August 14 2020, @05:46AM (7 children)
Ideals are great and all, but humans work for their daily bread, which is bought with money. Philanthropy is not a sustainable economic system.
(Score: 2, Insightful) by Anonymous Coward on Friday August 14 2020, @05:55AM (4 children)
But it is the only possible human system. Why do you think all those teachers teach for a pittance? Why do the first responders run toward danger when, seriously, they are not getting paid enough for that? Why do professors accept the lower income that they could have surpassed by prostituting their knowledge to industry? Philanthropy, that is why. Corporations and assholes like you are misanthropes, people-haters, and we all hate you back. Get your ass to Galt's Gulch, and die you incompetent excuse for a human being! And, I am being polite, so don't provoke me further.
(Score: 3, Informative) by FatPhil on Friday August 14 2020, @08:33AM (2 children)
And, apropos of nothing, where do you stand on the horrors of "multiple sclerisis"?
I personally think it's an abomination, and must be stamped out forthwith.
Multiple scleroses.
The clue's in the plurality.
There, I went there. Downmod me to hell, materhumpers.
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 1, Funny) by Anonymous Coward on Friday August 14 2020, @09:38AM
Yes, should have been "sclerises".
Very much like when one has multiple "narcosis/narcoses" or "scoliosis/scolioses" only for... oh, wait.
As for where one stands, σκληρός is hard enough to stand on top. Of the horror that is.
(Score: 2) by c0lo on Friday August 14 2020, @09:42AM
Hmmmm.
Do I fe... err, Phil enough of a materhumper this late Friday evening? (grin)
https://www.youtube.com/watch?v=aoFiw2jMy-0 https://soylentnews.org/~MichaelDavidCrawford
(Score: 0) by Anonymous Coward on Friday August 14 2020, @06:01PM
I never argued that people shouldn't do those things, just that you shouldn't expect people to do those things for free. Caring is a privilege of the rich! The poor have to "get it how you live". Expecting anyone to go beyond those very human impulses and do better is wishful thinking.
(Score: 0) by Anonymous Coward on Saturday August 15 2020, @01:01AM (1 child)
$2 per day? I do not think capitalism works the way you think it works.
What you're actually arguing is for people who did not do the actual work in the lab and field to pocket billions of dollars more than any of the workers at any step in the process were ever paid. You're defending rent-seekers.
(Score: 0) by Anonymous Coward on Saturday August 15 2020, @07:21AM
No, I'm not. I'm arguing that castigating people who work for profit rather than ideals is unrealistic and stupid. I'm down for the communist revolution, but until the rest of you get with it, we have to live in a capitalist reality. Arguing that the lab worker must be 100% devoted to helping humanity and 0% looking to get a paycheck is playing into the corporate bosses hands.
(Score: 3, Insightful) by aristarchus on Friday August 14 2020, @05:51AM
Plato said that a doctor who practices medicine to make money is a fee-collector, not a doctor. Mutandis mutandum, a medical researcher who hopes to strike is rich is a speculator, not a medical researcher. We have been over the sociopath question many times. I suggest you watch Darren Aronofsky's "Fountain" [youtube.com] for perspective. Death is the road to awe, not money.