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According to research published in the Journal of Clinical Pychopharmacology a double-blind clinical trial has shown that microdoses of LSD are effective at reducing pain.
With just three non-hallucinogenic "micro"doses, participants displayed what seemed to be an increase in pain tolerance and a decrease in subjective perceptions of pain. This prolonged response, the authors claim, is on par with up to 20 mg of oxycodone or morphine.
The size of the dosage, however, did matter. Any amount of LSD lower than 20 µg (which is considered a relatively large microdose among online users) did not seem to have this reported analgesic effect.
"The present data suggest that low doses of LSD might constitute a novel pharmacological therapy that can be efficacious in patients and is devoid of problematic sequelae [(chronic complications)] that are associated with current mainstay drugs, such as opioids," the authors conclude.
Existing research on LSD mechanisms is limited due to (now-relaxed) restrictions on its use in clinical trials; the underlying mechanism of the pain-reducing effect is not yet understood.
The authors conclude that the results "warrant further research."
Journal Reference:
A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers: [open], Journal of Psychopharmacology (DOI: 10.1177/0269881120940937)
(Score: 2, Insightful) by fakefuck39 on Monday August 31 2020, @07:23AM (5 children)
Ketamine is what's currently the standard when pain becomes too high for morphine. Then you step down to morphine. Then you step down to tramadol. Then you step down to codeine. There is nothing wrong with this process. I was on Ketamine followed by the stepped down opiates for 6 months. Unlike what movies tell us, there is no withdrawal after that time.
I had a quarter of my body burned with 3rd degree burns, a couple of places bones were showing. At the beginning, it was K right after the surgeries, followed by morphine, followed by K again - about half and half on each. 20mg is not a small dose - that's a dose that knocks you out completely. 10mg is not a small dose, and as a pill you can barely stay awake, if you try very hard. I've also done quite a bit of acid in highschool so know what that's like. A dose of acid that gets rid of as much pain as 20mg of morphine? That's a dose on which you can slice yourself open and be ok with it. You're tripping balls on an equivalent dose of acid - that a microdose can do the same is complete bs. Even a dose that has you tripping balls you feel pain just fine. The Ketamine dose that does that also has you tripping balls.
This "research" is a complete fabricated lie. If you go the current route, the tramadol phase gets you a pause from the morphene - like a break so you don't get addicted. The codeine turns to morphene but you can't take too high a dose of that w/o throwing up, so it can't be abused, and would take years of intake to get you any withdrawal symptoms. The abuse comes because people like feeling a little bit high, so they keep taking shit. Not because of any feelings of withdrawal. And you can have that urge with any drug. A nicotine vape and coffe is something I personally cannot quit. 6 months of painkillers? That was easy as shit, as soon as the bottle in my cabinet was empty. Thing is in most of europe you can get large doses of codeine at the pharmacy. No prescription required. I had to fly back to the states in order to quit that shit. But it's because I liked being high - which I'd do with lsd as well.
(Score: 0) by Anonymous Coward on Monday August 31 2020, @01:28PM
A reluctant +1.
Microdose LSD is not treating physical symptoms. It's helping deal with the mental reaction to chronic pain. It's giving you "fresh" eyes and getting you out of the same-old rut .
(Score: 0) by Anonymous Coward on Monday August 31 2020, @05:51PM
it's not a lie, just not explained properly. pain relief does not necessarily mean pain removal at the source like deadening nerves like opiods. You can get real, actual relief by not processing the pain in the same way. It's also possible the effect works better with different types of pain. Having burns may require the deadening action of actual pain "killers".
(Score: 2) by DannyB on Monday August 31 2020, @05:52PM (2 children)
Sorry to hear about what happened to you.
I hate tramadol. It made me feel this 'buzz' like I couldn't sit still. Couldn't be comfortable unless I was constantly moving my extremities (fingers, legs, arms, etc). This was given by arthritis specialist, to take every day. Auditory hallucinations was the final straw, so I quit. And that was another problem, because it's really addictive. I had already been taking my favorite hydrocodone for years, for occasional use, and decided to stick with that. I've had morphine injections a few times in my life, but it was scary how good that felt. I would have chosen a smaller dose if it had been up to me.
I had some really good stuff not quite a year ago for a quick routine ten year embarrassing procedure. Don't remember what the drug(s) was, but I was expecting someone from AT&T to show up to harvest my organs, and I didn't mind, because I seemed to think it was in the service agreement I had signed that they could take my organs and those of my family. Fortunately my wife had the presence of mind to record video before I was lucid.
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(Score: 1) by fakefuck39 on Monday August 31 2020, @10:05PM (1 child)
Egh, shit happens. In my case it was boiling peanut oil on the stove, and the shit boiling over the top, firing up from the stove, and exploding all over me and the kitchen. And of course the french landlord I was renting from thought it was a good idea for the fire extinguisher to be nice and secure. As in walk out the door, go to the basement, unlock the basement door with a key, unlock a storage locker with a different key, and get the fire extinguisher. While you're on fire. Oh the French. Beautiful country, very polite.
So tramadol was actually created to not be addictive. I don't know more than your doctor, but my theory is you had too much serotonin, and that was making you all weird. It boost your serotonin. A way to counter that is to have less b6 or less htp in your diet. You can also take some velvet bean to boost your dopamine, which would lower serotonin since they compete for an enzyme. Hydrocodone is an american thing they don't use in europe. There's a reason for that - it's basically heroin with lower potency. I'd sick to tramadol. Can you explain what you meant by addictive - like did you have physical withdrawal symptoms? You're not supposed to have those with it.
Question though - why morphine injections? Unless you're already on a drip, why not just a 6 or 9mg pill? If it was right after an accident I'd understand an injection, but you're not supposed to feel high on it. If you're in pain, opiates don't make you high. If they do, you're getting way too large of a dose. It's supposed to just make you not feel pain or make you fall asleep.
Honestly if you got something where you're on pain killers for years, opiates aren't the way to go. Tramadol is designed not to be addictive, but not meant to be taken for over a year. But Hydrocodone is way way worse. Seriously - have you tried toking the mary jay? But like in a vape or eating it so you don't get cancer and suffocate from the smoke.
(Score: 2) by DannyB on Tuesday September 01 2020, @01:54PM
One thing about tramadol was that I was in a good mood. All the time. Constantly. That just isn't natural. But I'm glad I'm off it. That was back in 2010.
In the 70's, middle school, I had morphine from a broken wrist. In 2016 and 2017 I had morphine a couple times at the ER for kidney stones.
The AT&T organ harvesting was after waking up from some kind of sedative for an outpatient procedure.
What you describe is probably why my arthritis specialist gave me tramadol. He can also write opiate prescriptions, but I get those from my primary care doctor. I only use hydrocodone occasionally, not routinely. I take potent prescription nsaids and lots of acetaminophen every day. The opiate if it is really bad. Even then, I try starting with half a tablet. I don't take it often enough or in large enough doses to have any problems with constipation or tolerance. I realize that if I had to take that stuff regularly, that story does not have a very nice ending.
I have not tried any mary jay for decades. I program in Java instead.
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