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According to research published in the Journal of Clinical Pychopharmacology a double-blind clinical trial has shown that microdoses of LSD are effective at reducing pain.
With just three non-hallucinogenic "micro"doses, participants displayed what seemed to be an increase in pain tolerance and a decrease in subjective perceptions of pain. This prolonged response, the authors claim, is on par with up to 20 mg of oxycodone or morphine.
The size of the dosage, however, did matter. Any amount of LSD lower than 20 µg (which is considered a relatively large microdose among online users) did not seem to have this reported analgesic effect.
"The present data suggest that low doses of LSD might constitute a novel pharmacological therapy that can be efficacious in patients and is devoid of problematic sequelae [(chronic complications)] that are associated with current mainstay drugs, such as opioids," the authors conclude.
Existing research on LSD mechanisms is limited due to (now-relaxed) restrictions on its use in clinical trials; the underlying mechanism of the pain-reducing effect is not yet understood.
The authors conclude that the results "warrant further research."
Journal Reference:
A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers: [open], Journal of Psychopharmacology (DOI: 10.1177/0269881120940937)
(Score: 2) by DannyB on Tuesday September 01 2020, @01:54PM
One thing about tramadol was that I was in a good mood. All the time. Constantly. That just isn't natural. But I'm glad I'm off it. That was back in 2010.
In the 70's, middle school, I had morphine from a broken wrist. In 2016 and 2017 I had morphine a couple times at the ER for kidney stones.
The AT&T organ harvesting was after waking up from some kind of sedative for an outpatient procedure.
What you describe is probably why my arthritis specialist gave me tramadol. He can also write opiate prescriptions, but I get those from my primary care doctor. I only use hydrocodone occasionally, not routinely. I take potent prescription nsaids and lots of acetaminophen every day. The opiate if it is really bad. Even then, I try starting with half a tablet. I don't take it often enough or in large enough doses to have any problems with constipation or tolerance. I realize that if I had to take that stuff regularly, that story does not have a very nice ending.
I have not tried any mary jay for decades. I program in Java instead.
The lower I set my standards the more accomplishments I have.