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posted by CoolHand on Saturday August 29 2015, @11:14PM   Printer-friendly
from the conducting-organically dept.

Rice University scientists have made a living circuit from multiple types of bacteria that prompts the bacteria to cooperate to change protein expression.
...
"The main push in synthetic biology has been to engineer single cells," Bennett said. "But now we're moving toward multicellular systems. We want cells to coordinate their behaviors in order to elicit a populational response, just the way our bodies do."

Bennett and his colleagues achieved their goal by engineering common Escherichia coli bacteria. By creating and mixing two genetically distinct populations, they prompted the bacteria to form a consortium.

The bacteria worked together by doing opposite tasks: One was an activator that up-regulated the expression of targeted genes, and the other was a repressor that down-regulated genes. Together, they created oscillations -- rhythmic peaks and valleys -- of gene transcription in the bacterial population.

The idea is to create "consortia" of engineered bacteria whose products can be switched on and off using chemical signals. Patients would ingest the consortia to treat conditions, and physicians would control the activity of the consortia by feeding the patients yogurt carrying control chemicals.


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  • (Score: 1, Funny) by Anonymous Coward on Saturday August 29 2015, @11:19PM

    by Anonymous Coward on Saturday August 29 2015, @11:19PM (#229608)

    Someone read "Prey" and ignored the cautionary parts of the cautionary tale and decided to use E-coli to make grey goo a reality for real? What could possibly go horribly wrong?!

    • (Score: 3, Interesting) by Farkus888 on Sunday August 30 2015, @12:07AM

      by Farkus888 (5159) on Sunday August 30 2015, @12:07AM (#229622)

      I've been referencing that book for a decade. Don't bother, Spielberg didn't make it into a movie so no one knows about it. You would be better served by finding a way to show how the latest season of American Idol teaches the same moral.

      • (Score: -1, Troll) by Anonymous Coward on Sunday August 30 2015, @12:16AM

        by Anonymous Coward on Sunday August 30 2015, @12:16AM (#229625)

        If it were made into a movie today, the main character would be a South Asian lesbian coder whose wife was being replaced by nanobots.

  • (Score: 2) by MichaelDavidCrawford on Saturday August 29 2015, @11:20PM

    by MichaelDavidCrawford (2339) Subscriber Badge <mdcrawford@gmail.com> on Saturday August 29 2015, @11:20PM (#229609) Homepage Journal

    wouldn't it be better to do this with something that won't rise up to give its creator Montezuma's Revenge?

    --
    Yes I Have No Bananas. [gofundme.com]
    • (Score: 0) by Anonymous Coward on Saturday August 29 2015, @11:22PM

      by Anonymous Coward on Saturday August 29 2015, @11:22PM (#229611)

      Science Funding is more important than Science Ethics. Scientists! Fucking over the Universe, for Profit!

      • (Score: 0) by Anonymous Coward on Sunday August 30 2015, @06:47AM

        by Anonymous Coward on Sunday August 30 2015, @06:47AM (#229722)

        You read the DuPont story also.