Submitted via IRC for TheMightyBuzzard
For the first time, scientists were able to correct the genetic mutation that causes sickle cell disease in stem cells.
In a collaborative effort, researchers at UC Berkeley, UC San Francisco Benioff Children's Hospital Oakland Research Institute (CHORI), and the University of Utah School of Medicine fixed the mutation in modified stem cells from patients with the condition using a CRISPR/Cas9 gene editing approach.
The study, "Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells," was published in the journal Science Translational Medicine.
The scientists hope to re-infuse patients with the modified stem cells and alleviate disease symptoms.
"We're very excited about the promise of this technology," Jacob Corn, senior author on the study and scientific director of the Innovative Genomics Initiative at UC Berkeley, said in a news release. "There is still a lot of work to be done before this approach might be used in the clinic, but we're hopeful that it will pave the way for new kinds of treatment for patients with sickle cell disease."
(Score: 4, Funny) by Snotnose on Sunday October 23 2016, @03:05AM
Means you have to have the cops shoot more innocent darkies to make up for those who survive sickle cell! Dafuq you thinking scientists, we have standards to maintain here!
When the dust settled America realized it was saved by a porn star.
(Score: 3, Insightful) by Snotnose on Sunday October 23 2016, @03:09AM
Ayup, another moderation lottery here. Insightful, funny, sad, troll, something else. Place your bets here folks, just wish I could make money off this comedy gold.
When the dust settled America realized it was saved by a porn star.
(Score: 2) by Runaway1956 on Sunday October 23 2016, @03:09AM
Amusing - I like dark humor. But, someone will be along soon to mod you a troll.
(Score: 2) by Snotnose on Sunday October 23 2016, @03:11AM
Seems to me being modded a troll knocks you down to 0 points, even if you were +5 insightful. Or am I not hitting F5 on my own posts often enough?
When the dust settled America realized it was saved by a porn star.
(Score: 3, Informative) by Runaway1956 on Sunday October 23 2016, @03:25AM
I've never looked into the mechanics, but I think it's straight math. +1 -1 +1 +1 -1 = 1
The only mod that really screws things up, is the spam mod. Think that's -25 - mod bombers did that a few times early on, and brought a person's karma down to the pits of hell. Those abuses were quickly addressed, and we don't see that now.
So, if you find a post modded to -5, that means at least five people have down modded it, and the descriptor tells you which down mod was used the most.
(Score: 3, Informative) by The Mighty Buzzard on Sunday October 23 2016, @10:37AM
Spam's only -1 to the comment same as everything else. It's a -10 hit to the user's karma though.
My rights don't end where your fear begins.
(Score: 2) by The Mighty Buzzard on Sunday October 23 2016, @10:43AM
Just for kicks, at the time of this posting the post in question has two Offtopic, one Informative, and two Funny moderations for a net total of +1.
My rights don't end where your fear begins.
(Score: 0) by Anonymous Coward on Sunday October 23 2016, @07:25AM
ur moderated as troll. i up-moderated parent because it was classic.
(Score: 0, Offtopic) by Snotnose on Sunday October 23 2016, @03:17AM
It's 8:17 local time on a Saturday night. I'm listening to Steven Wilson on headphones being snarky on some random website. The Steven Wilson part is all good, the being snarky on some random website, not so much.
I need to get a life. Or 30 years younger, when having a life didn't involve so much physical activity.
When the dust settled America realized it was saved by a porn star.
(Score: 2) by Magic Oddball on Sunday October 23 2016, @03:37AM
One of my hospital roommates in 1990 was a toddler/preschooler who was very sick and in a LOT of pain thanks to SCD anemia. Out of the 20+ kids I shared rooms with over the years, she was one of the very few who made no effort to interact or play, and I don't think they expected her to reach puberty.
Obviously treatments for SCD are already a hell of a lot better than back then, but it's still a pretty nasty disorder for someone to be saddled with, so I'm glad they've found a likely solution.
(Score: 1) by sbgen on Sunday October 23 2016, @04:43AM
Time to whine aloud. I will have to wait for Monday to read the article-it is lovingly placed behind paywall. The cure for SCD might arrive ealrier than for the publication problem :-(( :-((
Warning: Not a computer expert, but got to use it. Yes, my kind does exist.
(Score: 1, Informative) by Anonymous Coward on Sunday October 23 2016, @04:53AM
https://en.wikipedia.org/wiki/Sci-Hub [wikipedia.org]
(Score: 2) by janrinok on Sunday October 23 2016, @12:27PM
The second link is still good here.
(Score: 0) by Anonymous Coward on Sunday October 23 2016, @02:55PM
I thought maybe there was real progress until I read this. Too bad all the hype surrounding that attracted the scammers and now it is ruined.