A compound called the Integrated Stress Response inhibitor (ISRIB) may restore memory by reversing the effects of traumatic brain injury (in mice):
Whether caused by a car accident that slams your head into the dashboard or repeated blows to your cranium from high-contact sports, traumatic brain injury can be permanent. There are no drugs to reverse the cognitive decline and memory loss, and any surgical interventions must be carried out within hours to be effective, according to the current medical wisdom. But a compound previously used to enhance memory in mice may offer hope: Rodents who took it up to a month after a concussion had memory capabilities similar to those that had never been injured.
The study "offers a glimmer of hope for our traumatic brain injury patients," says Cesario Borlongan, a neuroscientist who studies brain aging and repair at the University of South Florida in Tampa. Borlongan, who reviewed the new paper, notes that its findings are especially important in the clinic, where most rehabilitation focuses on improving motor—not cognitive—function.
[...] In 2013, the lab of Peter Walter, a biochemist at the University of California, San Francisco (UCSF), discovered a compound—called ISRIB—that blocked the stress response in human cells in a dish. Surprisingly, when tested in healthy mice, ISRIB boosted their memory. Wondering whether the drug could also reverse memory impairment, Walter teamed up with UCSF neuroscientist Susanna Rosi to study mouse models of traumatic brain injury. First, they showed that the stress response remains active in the hippocampus, a brain region important for learning and memory, for at least 28 days in injured mice. And they wondered whether administering ISRIB would help.
Rosi and her team first used mechanical pistons to hit anesthetized mice in precise parts of their surgically exposed brains, resulting in contusive injuries, focused blows that can also result from car accidents or being hit with a heavy object. After 4 weeks of rest, Rosi trained the mice to swim through a water maze, where they used cues to remember the location of a hidden resting platform. Healthy mice got better with practice, but the injured ones didn't improve. However, when the injured mice were given ISRIB 3 days in a row, they were able to solve the maze just as quickly as healthy mice up to a week later [open, DOI: 10.1073/pnas.1707661114] [DX], the researchers report today in the Proceedings of the National Academy of Sciences.
(Score: 2) by Runaway1956 on Tuesday July 11 2017, @01:45PM (1 child)
So, the mice have better health care plans than any of us? Why are they taking better care of the mice, than us? Is this one of those questions, whose answer is 42?
(Score: 2) by bob_super on Tuesday July 11 2017, @03:52PM
Runaway:
> Why are they taking better care of the mice, than us?
TFS:
> "used mechanical pistons to hit anesthetized mice in precise parts of their surgically exposed brains"
Did you not get funded for pistons, so your doctor uses a baseball bat instead?
What are you demanding, Abu Graib privileges?
Maybe it's just me, but I'm oddly ok with not getting treated for the high-precision injuries not inflicted by curious scientists to my brain.
(Score: 2) by RamiK on Tuesday July 11 2017, @02:07PM (2 children)
At a really steep price too... One wonders just how generous and rigorous academia must be to run dozens of trials and only produce a couple of papers in 3 years... *cough*selective publishing*cough*...
compiling...
(Score: 2) by rondon on Tuesday July 11 2017, @02:22PM (1 child)
Over $10 a mg, that does seem steep. I guess I don't know the dosing, though. When you coughed, what was your meaning? I feel like there are a ton of problems in science right now, especially science publishing, but I didn't understand the reference.
I know my experience is anecdotal and unscientific, but when I had my only diagnosed concussion (missing about 5 minutes of my life on that one) I felt like my brain never worked quite as quickly after. I really hope this research can help people in those circumstances.
(Score: 3, Insightful) by takyon on Tuesday July 11 2017, @03:20PM
I looked up "ISRIB dosing".
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385927/ [nih.gov]
Assuming a 70 kg human, that's 17.5 mg or $175 a day if your quoted price is accurate. However, dosage may not translate from mice to humans (or effects for that matter).
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: 2) by kaszz on Tuesday July 11 2017, @04:31PM (1 child)
St. Olaf College, Minnesota have a really nice interactive 3D-model [stolaf.edu] of the ISRIB molecule, linked from the wikipedia page. Btw, I think I recall some similar substance for car injury and stroke victims ~10 years ago. It might just work for a lot of other brain injuries.
(Score: 0) by Anonymous Coward on Tuesday July 11 2017, @06:20PM
Yes. Calico is unlikely to be interested just for TBIs.
(Score: 0) by Anonymous Coward on Tuesday July 11 2017, @07:27PM
http://www.pnas.org/cgi/doi/10.1073/pnas.1707661114 [pnas.org]
I don't see why they claim all animals fully recovered when they had to exclude an unknown amount due to skull fractures. Probably related, they write:
So were there many mice that received very severe injuries but just a few that had minor ones ? I originally took a look because I wanted to see how they judged that the damage was consistent across groups. They don't seem to have checked that at all, and from this description it appears to vary wildly (from fractured skull and has to be dropped from the study to "fully recovered").
It also isn't clear whether the post-mortem electrophysiology was done on mice that were also tested for behavior in some way. If so, where is the scatter chart of their supposed cause and effect? If not, that seems like a waste of animals to me (which, besides being bad science, is a federal crime).
Also it is weird to see them mention at the beginning of that quote that "nontraumatic ear bars" were used for this procedure.