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posted by cmn32480 on Thursday August 24 2017, @11:48AM   Printer-friendly
from the knee'ds-joint-research dept.

Arthur T Knackerbracket has found the following story:

Mechanical loading, or forces that stimulate cellular growth for development, is required for creating cartilage that is then turned to bone; however, little is known about cartilage development in the absence of gravity or mechanical loads. Now, in a study led by the University of Missouri, bioengineers have determined that microgravity may inhibit cartilage formation. Findings reveal that fracture healing for astronauts in space, as well as patients on bed rest here on Earth, could be compromised in the absence of mechanical loading.

"Cartilage tissue engineering is a growing field because cartilage does not regenerate," said Elizabeth Loboa, dean of the MU College of Engineering and a professor of bioengineering. "Because these tissues cannot renew themselves, bioreactors, or devices that support tissue and cell development, are used in many cartilage tissue engineering applications. Some studies suggest that microgravity bioreactors are ideal for the process to take place, while others show that bioreactors that mimic the hydrostatic pressure needed to produce cartilage might be more ideal. Our first-of-its-kind study was designed to test both theories."

Chondrogenic differentiation is the process by which cartilage is developed and cartilage is the basis for bone formation in the body. Additionally, cartilage does not renew itself once it breaks down or fails in the body, making it a target for bioengineers who wish to help patients regenerate cartilage from other cells.

Journal Reference: Liliana F. Mellor, Andrew J. Steward, Rachel C. Nordberg, Michael A. Taylor, Elizabeth G. Loboa. Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC. Aerospace Medicine and Human Performance, 2017; 88 (4): 377 DOI: 10.3357/AMHP.4743.2017

-- submitted from IRC


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  • (Score: 0) by Anonymous Coward on Thursday August 24 2017, @04:11PM (3 children)

    by Anonymous Coward on Thursday August 24 2017, @04:11PM (#558484)

    Apparently, no one cares about cartridge...

    • (Score: 2, Funny) by aristarchus on Thursday August 24 2017, @08:29PM

      by aristarchus (2645) on Thursday August 24 2017, @08:29PM (#558578) Journal

      No comments.

      Just an observation. Don't Spam mod me, bro!!

    • (Score: 0) by Anonymous Coward on Friday August 25 2017, @02:15AM

      by Anonymous Coward on Friday August 25 2017, @02:15AM (#558693)

      no one cares about cartridge

      Only ammosexuals. And usually it is more about the projectile and the powder charge, and muzzle velocity. Only sharks are really into cartilage.

    • (Score: 2) by cubancigar11 on Friday August 25 2017, @07:05PM

      by cubancigar11 (330) on Friday August 25 2017, @07:05PM (#559070) Homepage Journal

      Not many bio nerds I suppose.

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