from the I'm-not-kissing-it,-you-kiss-it! dept.
The drug Gefitinib is used to treat breast, lung, and other cancers by inhibiting epidermal growth factor receptor (EGFR) signaling, but it has only a limited effect on prostate cancer. EGFR, present on the cell membrane, is involved in cell proliferation and the development of dermis, lung, and digestive tissues. When a mutation causes its over-activation, it can lead to increased cell proliferation and tumor formation.
Tadashi Matsuda of Hokkaido University and his colleagues in Japan investigated human prostate cancer cells to determine if there is an unknown up-regulation mechanism in the EGFR pathway.
When EGFR is attached to a small protein called ubiquitin, it is given "the kiss of death" and tagged for degradation inside the cell. This tagging process is facilitated by a protein called c-CBL. The degradation of EGFR leads to less signaling from the receptor and reduced cell proliferation.
Matsuda and his team found that signal-transducing adaptor protein-2 (STAP-2) stabilizes EGFR by inhibiting its c-CBL-mediated ubiquitination. Furthermore, when the team suppressed STAP-2, the prostate cancer cells showed reduced proliferation and did not form a tumor when transplanted into mice.
"STAP-2 inhibitors could play a role in treating Gefitinib-resistant prostate cancers. Further studies on STAP-2 will provide new insights into cancer physiology and support the development of anticancer therapies," says Tadashi Matsuda. The study was published in the Journal of Biological Chemistry.
(Score: -1, Offtopic) by Anonymous Coward on Monday December 25 2017, @06:06AM (1 child)
aside: ubiquitin is super interesting
contrubutor - this sciencedaily author is muddled and so can't clearly explain
(Score: 2) by takyon on Monday December 25 2017, @12:47PM
Hokkaido University, not SD.
Japanese uni press releases sometimes suck but that one seemed OK.
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: -1, Offtopic) by Anonymous Coward on Monday December 25 2017, @07:55AM
What we really need is a method of extracting cancer from a woman's breast and injecting it into a man's prostate so all men die of cancer.
(Score: 2) by Runaway1956 on Monday December 25 2017, @09:43AM (37 children)
I just get this vision of the doctor kissing people's prostates. Which, some people may not mind, except for the fact that the doctor uses a scalpel to get right in there.
(Score: 0) by Anonymous Coward on Monday December 25 2017, @12:20PM
Decades back, there was a TeeVee commercial that said "Kiss your hemorrhoids goodbye."
Comedian John Mendoza incorporated it into his act with the response "Not even I could."
-- OriginalOwner_ [soylentnews.org]
(Score: 0) by Anonymous Coward on Monday December 25 2017, @12:51PM (35 children)
Where is the guardian angel of kissin' prostates? Nowhere, best we will get is a robot.
(Score: 3, Funny) by Azuma Hazuki on Monday December 25 2017, @04:11PM (34 children)
I bet Runaway knows. That's the first thing that springs to mind for him, did you notice? Guy like that *has* to have some experience...
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Monday December 25 2017, @07:21PM (33 children)
This is not OKCupid. You can quit stalking me now.
(Score: 2) by Azuma Hazuki on Tuesday December 26 2017, @02:51AM (32 children)
And miss out on all these hilarious reactions, watching you slowly break down in a rising bubble of your own bile? Not a chance. Every time you reply you get more and more desperate. I'm going to see just how low you sink.
I am "that girl" your mother warned you about...
(Score: 1, Flamebait) by Runaway1956 on Tuesday December 26 2017, @04:36AM (31 children)
I understand, Zumi. It's not like you actually have a life, or interests, or anything.
(Score: 2) by Azuma Hazuki on Tuesday December 26 2017, @06:22AM (30 children)
Oh, I do. This just happens to be one of them :) 50+ hours a week working, Linux, cooking, and I plan to start some basic woodworking soon (already got the bedframe plans and just need the tools and lumber), and a little bit of watching sad, lonely lunatics like you digest themselves alive.
You keep pitching me these nice, easy, lazy fastballs right over the middle of the plate, and I'll keep smacking them into low-earth orbit.
I am "that girl" your mother warned you about...
(Score: 1, Troll) by Runaway1956 on Tuesday December 26 2017, @12:01PM (29 children)
Uh-huh. One of the funny things about all your silliness is, you have no idea how abnormal YOU are. All that you're doing is projecting your own abnormalities on me.
(Score: 2) by Azuma Hazuki on Tuesday December 26 2017, @08:25PM (28 children)
Oh, I know precisely how abnormal I am, and I am *proud* of it. Have you seen what passes for normal these days? You're way more "normal" than me in social terms in at least half a dozen ways I can count, not least of which is your complete unthinking instinctual selfishness.
Keep 'em coming, Runaway. I can keep it up (haw) longer than you can, old man, and thou knowest it well in thy reins.
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Tuesday December 26 2017, @08:55PM (27 children)
So, you're saying that asocial assholes are "normal" these days? Or, are they merely more normal than you?
(Score: 2) by Azuma Hazuki on Wednesday December 27 2017, @03:30AM (26 children)
Did I strike a nerve somewhere, Runaway? You can't seem to maintain your calm around me for very long, I can't help but notice. Maybe because I've got a thing for picking at peoples' psychic scabs...and you, Runaway, are a walking mass of crusted-over old wounds. "Asocial asshole" sounds like a fair description of you and people who think and act like you, though I'd say "antisocial" is a better fit since you seem to actively want people to suffer.
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Wednesday December 27 2017, @08:45AM (25 children)
You would say antisocial, because you don't understand what either term means. You social animals can only understand "social" and it's antonym, "antisocial". If you need me to, I can explain how and why I'm not antisocial.
But, you keep telling yourself how badly you're beating me up. One time in all of our discourse, you came close to hitting a nerve. I observed at that time that you are a cruel, wicked wench. But, even then, you only came close. Keep trying thought - it's kinda fun watching you fail.
(Score: 2) by Azuma Hazuki on Wednesday December 27 2017, @08:28PM (24 children)
You don't even know how much of yourself you're revealing here, do you? And given what you just posted, I understand why a little more now. Gods above, below, and in between, you're a sad case...
I am "that girl" your mother warned you about...
(Score: 1, Flamebait) by Runaway1956 on Thursday December 28 2017, @12:40AM (23 children)
So, once again, you have nothing to say, and resort to insults. Interesting . . . And, you do realize that all the while you are phishing me, you're exposing yourself? Pull your pants up, Zumi.
(Score: 1, Troll) by Azuma Hazuki on Thursday December 28 2017, @04:07AM (22 children)
What exactly is being exposed that people here don't know already? They know my name, they know I'm gayer than Ellen and Portia on a lavender tandem bike, they know I'm from Milwaukee, they know I'm bouncing my traffic out of a couple of proxies in Dane County...I've been forthright about all this because I truly have nothing to hide.
Was that a threat, Runaway? Have I upset you to the point that you're starting to internet-tough-guy posture, you l33+ h4XX0r j00? This should be darkly amusing...
I am "that girl" your mother warned you about...
(Score: 1, Flamebait) by Runaway1956 on Thursday December 28 2017, @05:24AM (21 children)
Uhhhh - you're the insecure person here, with the tough-guy attitude. No rational person can look at my post(s) and find any threat. That shit is all in your head, 'Zumi. And, you're projecting, yet again.
(Score: 1, Troll) by Azuma Hazuki on Thursday December 28 2017, @06:13AM (20 children)
Keep 'em coming, old man. The more you post, the more you reveal, by small bits, precisely what your major malfunction is. I've already guessed it, but I want to see how long it takes for the rest of the site to cotton on. You've long since passed the event horizon of your own asshole, so unfortunately you probably can't be saved, but you can at least provide some schadenfreude for the rest of us.
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Thursday December 28 2017, @07:23AM (19 children)
"event horizon of your own asshole"
Good one. You studied under Jung?
(Score: 1, Troll) by Azuma Hazuki on Thursday December 28 2017, @09:00PM (18 children)
No, I've never read Jung. I just know a walking Klein bottle when I see one. How do you breathe like that? Are you one of those weird diblastic types that only has one orifice for everything? Because that would explain a *lot.*
I am "that girl" your mother warned you about...
(Score: 1, Troll) by Runaway1956 on Friday December 29 2017, @12:57AM (17 children)
You're phonograph needs a nudge, you're stuck in one track.
(Score: 1, Troll) by Azuma Hazuki on Friday December 29 2017, @04:25AM (16 children)
1) Your*
2) I've moved onto VBR Ogg Vorbis, thanks; no vinyl here
3) As they say in the old country, "Krai sum moar." Looks like you finally hit the bottom of the barrel.
I am "that girl" your mother warned you about...
(Score: 1, Redundant) by Runaway1956 on Friday December 29 2017, @05:16AM (15 children)
And, you've still got nothing more important to do, than to blather at me, and moderate all my posts as troll? And, oh yeah, being pedantic. You knew exactly what I meant, after all.
(Score: 1, Troll) by Azuma Hazuki on Friday December 29 2017, @08:40PM (14 children)
It sure does get under your wrinkly liver-spotted skin though, doesn't it? :)
I am "that girl" your mother warned you about...
(Score: 1, Troll) by Runaway1956 on Saturday December 30 2017, @03:33AM (13 children)
No, not really. You're attibuting yourself more importance than you deserve. I kinda pity you, except, you seem to deserve your circumstances.
(Score: 2) by Azuma Hazuki on Saturday December 30 2017, @04:08AM (12 children)
So, your playbook is basically "accuse your opponent of what you yourself are guilty of, to the letter, before (s)he does it to you" then. That's really old, and really ineffective. It's not working for the President, for most of the same reasons, so what makes you think it'll work for you?
I've karma and mod points to burn, old man. I'd really rather be upvoting insightful and informative posts, but if you insist...
I am "that girl" your mother warned you about...
(Score: 1, Troll) by Runaway1956 on Saturday December 30 2017, @04:43AM (11 children)
*sigh*
So that's what this is all about? You are playing games with the moderation? Nothing more to do, than try to prove that you have a bunch of troll mods to play with? Jesus Christ, little girl, get a life. Try to act like the really clever STEM genius that you claim to be.
Oh, forget that. Stay down there in the muck and sludge, playing moronic games.
That movie, Deliverance - weren't you in the kitchen, burning water, while your brighter brother sat on the porch playing the fiddle?
(Score: 2) by Azuma Hazuki on Saturday December 30 2017, @05:05PM (10 children)
I never watched Deliverance, but seeing as you're the guy who spent time in the Navy and gets squicked out by gay men, something tells me you're the one who's squealed like a piggy before. You're also revealing your own perceived inadequacies; you ought to watch what you post a little more closely...
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Saturday December 30 2017, @05:43PM (9 children)
Inadequacies. I'm sensing something here . . . Zumi is familiar with them. Tell us more, Zumi.
(Score: 2) by Azuma Hazuki on Saturday December 30 2017, @06:01PM (6 children)
When you say things like "pretend to be that STEM genius" that don't actually correspond to anything I've said or done, what that reveals is that you yourself are one of the aggrieved types who hates "eggheads," the college educated, "liberal elites," whatever slur you want to use.
This is why I call you out for projection. And Dunning-Krugeritis. You really are not even half as clever as you think, and you leak metadata like a rusty sieve. You don't think before you post, and the result of that is that you reveal far more of yourself and your psychological makeup than you intend to. And I'm sure it's not just me who can see that.
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Saturday December 30 2017, @06:52PM (5 children)
You most certainly have stated that you are smarter than - what was it, 92% of the people around you? Genius. If your statement is true, you are genius level, or maybe a little better. You also have stated that you have done programming, and that your job is a tech job. Don't make me go searching for the posts in which you have made these statements and claims.
Hates eggheads? Uh-huh. Once again, you miss the boat by miles. You could have been one of those Iranian army gunners who decided to shoot at us, and missed by miles, literally. You better run all that metadata that you've been collecting right back through your egghead.
Admit it - as smart as you may or may not be, you're a fucking failure as a psychologist, psychiatrist, or analyst, or whatever the hell you're attempting to be here.
(Score: 2) by Azuma Hazuki on Saturday December 30 2017, @07:49PM (4 children)
Strictly speaking, an IQ of 150+ is genius level, and I'm a few points off that, 145 or so if the correlation to SAT and GRE scores (which, by the way, I did *not* study for) are any indication. And yes, one of my jobs is tech, and yes, I have an earth sciences degree.
And...so what?
See, you seem to think everyone with this kind of brainpower and that kind of degree is some latte-swilling arrogant hipster jackoff with a macbook and a trust fund. Not so. I come from generational poverty in NYC. I've been homeless. I've eaten out of more trash cans and dumpsters than I care to count. I've suffered and survived the worst kinds of betrayals from family, friends, employers, even a lover, and am still standing. Odds are good you have completely the wrong idea about me, and, ONCE AGAIN, you are attempting to deflect from your own shortcomings by accusing your opponent of them first.
Your fundamental issue is ignorant solipsism. Every human suffers from this to a degree, but you are refining it, if that's the right word, to an art form (and this is definitely not the right word). Your posts are the equivalent of Trump tweeting that he's never seen a thin person drinking a Diet Coke, while he himself weighs over 250lb and downs literally a dozen of them a day.
To address your "difference between asocial and antisocial" post; first, I'm surprised you had the honesty--or is it sheer autism?--to admit that out loud. You've probably never been diagnosed with anything, and while I am not a licensed psychiatrist, I personally suspect a degree of schizoid personality disorder. It fits your posting style, your subjects, your diction, and your disdain for, ahem, "social animals" to a T.
I'll give you this one for free: schizoid or not, humans *are* social animals. You fail because you constantly war with your own nature and are unable to connect to other sane human beings.
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Saturday December 30 2017, @09:17PM (3 children)
That's why you're so bitchy? You think that I think? Well, first off, I told you a long time ago - IT SHOULDN'T FUCKING MATTER TO YOU WHAT I THINK!!!! Jesus - we're here to exchange ideas. You want to take it PERSONAL? Here - watch this video - https://www.youtube.com/watch?v=VGUL4zdNU9k [youtube.com] Take Chopper's advice, and get over yourself. It just doesn't matter what ANYONE thinks.
Secondly, I've never said that I thought anything like that - because I don't think that. FFS - talk about projecting!! What I think is - you're bitchy, you're overly sensitive, and you're gay - and I don't like any of those things. But - WHY THE FUCK DOES ANY OF THAT MATTER TO YOU? Are you going to try to change your life, because of me? Like fuck. Just accept that you're overly bitchy, you're overly sensitive, and your gay, and I disapprove of those traits or qualities, and GET ON WITH YOUR OWN FUCKING LIFE! Because, my opinion don't mean shit, now does it? In short, grow up. You're 32, so just grow up. Some people don't like you, and it doesn't matter.
Schizoid? Nope. Good thing you're not a licensed head shrinker. Don't try to join the Moro tribe, cause you ain't got it in you to shrink heads.
Humans are almost all more or less social animals. None of us is an island. We depend on each other for all sorts of things. Some of us are more dependent than others. I'm asocial, because I don't need or want constant companionship and other people's approval. You are social, because you need people's approval. Witness your posts, in which you lash out at me, for having the audacity to not approve of you.
I don't even pretend to be a head shrinker, but I've got you pegged.
As for my "issues" - solipsism or whatever - I'm perfectly aware of who and what I am - and I'm comfortable with it. Unlike yourself. Sorry, if this is some kind of contest that you're engaged in, you're just not making any points. Again - I'm an asocial asshole, and you have no idea how to deal with me, or to manipulate me, or even how to impress me. If this is a contest, it looks like I win today.
I have a better idea though. How about we end the contest, and agree to just fucking disagree on a whole bunch of shit. You're liberal, but that doesn't necessarily make you a demon. I'm much more conservative than you, and that doesn't make me a demon either.
Now, go watch Chopper. Then watch him again. Hell, watch all his videos. Crazy bastard that he is (was, rather) he had some good advice for people.
(Score: 2) by Azuma Hazuki on Sunday December 31 2017, @03:13AM (2 children)
That is a lot of words to reiterate that you're an unrepentant asshole. Why not just say so in the first place? You do, again, though, nicely prove just about every point I made there :) I have to thank you for doing the heavy lifting for me.
Thanks for admitting you hate gays too, not that it would take a freaking telepath to figure that one out. Odds are you're annoyed I do better with women than you...
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Sunday December 31 2017, @04:32AM (1 child)
When you repent for being female, I might repent for being me.
(Score: 2) by Azuma Hazuki on Sunday December 31 2017, @04:48AM
Okay, Runaway, this is what we in the real world refer to as a category error. I'm female because I have zero Y and 2 X chromosomes. You're an asshole because you choose to be. And that post was one of the shortest, simplest, and most effective possible ways you could have demonstrated it. I am in awe, and grateful that you're so willing to double down on this self-destructive stupidity over and over and over again.
We get it. You don't care what people think of you. Keep that up, please; eventually you're going to not-care-what-people-think-of-you yourself into the poorhouse or the morgue. The downside of this attitude is simply that you're outnumbered, unjust as that may seem; you'd do well to emulate normalcy...although, I seem to recall in an earlier post, you were trying to insult me by implying I was abnormal, and you weren't...? Odd, that. Bit of a contradiction there.
I am "that girl" your mother warned you about...
(Score: 2) by Azuma Hazuki on Saturday December 30 2017, @06:05PM (1 child)
Here's another example from further upthread: "You would say antisocial, because you don't understand what either term means. You social animals can only understand "social" and it's antonym, "antisocial". If you need me to, I can explain how and why I'm not antisocial."
Analyze that snippet for a bit. Can you emulate a sane person long enough to see some of what that implies, and what you've indirectly admitted to here?
I am "that girl" your mother warned you about...
(Score: 2) by Runaway1956 on Saturday December 30 2017, @06:55PM
Another failure, as an analyst. You analyze it. If you still don't understand the difference between antisocial and asocial, let me know.