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posted by martyb on Monday February 12 2018, @08:13AM   Printer-friendly
from the so-that's-why-I-can't-sleep-when-I'm-wound-up? dept.

It's well known that the human body functions on a 24-hour, or circadian, schedule. The up-and-down daily cycles of a long-studied clock protein called Rev-erb coordinates the ebb and flow of gene expression by tightening and loosening loops in chromosomes, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings appear online this week in Science First Release.

Over the last 15-plus years, a team led by the new study's senior author Mitchell A. Lazar, MD, PhD, director of Penn's Institute for Diabetes, Obesity, and Metabolism, has been teasing out the versatile role of Rev-erb in maintaining daily cycles of the body's molecular clock, metabolism, and even brain health.

"Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes," Lazar said. "Proteins such as Rev-erb are the gears of the clock and understanding their role is important for investigating these and many other diseases."

Penn Medicine News

Yong Hoon Kim, Sajid A. Marhon, Yuxiang Zhang, David J. Steger, Kyoung-Jae Won, Mitchell A. Lazar. Rev-erbĪ± dynamically modulates chromatin looping to control circadian gene transcription. Science, 2018; eaao6891 DOI: 10.1126/science.aao6891

Original Submission

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  • (Score: 2) by shortscreen on Monday February 12 2018, @11:03AM

    by shortscreen (2252) Subscriber Badge on Monday February 12 2018, @11:03AM (#636629) Journal

    It's well known that the human body functions on a 24-hour, or circadian, schedule.

    My body functions within the limitations of a 24-hour schedule. Sometimes.