Purdue researcher Luis Solorio has helped create a lifelike cancer environment out of polymer to better predict how drugs might stop its course.
Previous research has shown that most cancer deaths happen because of how it spreads, or metastasizes, in the body. A major hurdle for treating cancer is not being able to experiment with metastasis itself and knock out what it needs to spread.
Studies in the past have used a 3-D printer to recreate a controlled cancer environment, but these replicas are still not realistic enough for drug screening.
"We need a much finer resolution than what a 3-D printer can create," said Solorio, an assistant professor of biomedical engineering.
Rather than 3-D printing, Solorio and a team of researchers have proposed 3-D writing. The device that they developed, a 3-D jet writer, acts like a 3-D printer by producing polymer microtissues as they are shaped in the body, but on a smaller, more authentic scale with pore sizes large enough for cells to enter the polymer structure just as they would a system in the body.
3-D jet writing is a fine-tuned form of electrospinning, the process of using a charged syringe containing a polymer solution to draw out a fiber, and then deposit the fiber onto a plate to form a structure. This structure is a scaffold that facilitates cell activity.
[...] "Ideally, we could use our system as an unbiased drug screening platform where we could screen thousands of compounds, hopefully get data within a week, and get it back to a clinician so that it's all within a relevant time frame," Solorio said.
(Score: 2, Interesting) by Geezer on Monday March 05 2018, @12:24AM
Although I'm already Stage 4 and this research is a bit late for me, it looks to a promising step toward identifying the trigger for metastasis and a possible treatment.
I wish them well.