Submitted via IRC for SoyCow8093
For the first time, researchers are pointing out the influence of the internal clock on atherosclerosis. Their study gives an important indication on how the therapeutic approach can be improved.
Oliver Söhnlein researches molecular mechanisms underlying atherosclerosis at the Institute for Cardiovascular Prevention. During this disease, lipid deposits can form on the inner vascular wall of large arteries. Cells of the immune system travel from the blood to the damaged location and attract more and more cells via signaling substances until the immune reaction finally derails. Atherosclerotic inflammation develops over years; however, the recruitment of cells is subject to circadian rhythms as Söhnlein has proven in mouse models of atherosclerosis. "At certain times of the day, three times as many leukocytes travel to the center of arterial inflammation as it is the case for other times," says Söhnlein. This rhythmic migration pattern is about 12 hours phase shifted with the recruitment pattern observed in the microcirculation in small veins.
Precisely this shift between the two vascular systems is interesting from a therapeutic aspect. "The recruitment of white blood cells in the micro-circulation is important for acute infections such as for example a lung or bladder infection," explains Oliver Söhnlein. Ideally, the recruitment of immune cells is to be stopped for the atherosclerotic inflammation but not in the micro-circulation.
The researchers of LMU achieved just that with their work in an early stage of atherosclerosis: On the one hand, they identified the molecular mechanism how rhythmic arterial leukocyte migration is controlled. On the other hand, timed inhibition of this pathway centered on the chemokine CCL2, they were able to stop the recruitment only into atherosclerotic areas but did not affect microvascular leukocyte migration. "Our study shows how circadian patterns can be used for timed therapeutic intervention possibly with lower side effects and higher efficacy," says Söhnlein.
In further studies the researchers want to examine to which extent circadian rhythms contribute to destabilization for advanced atherosclerosis. In addition, they want to focus on studying the circadian regulation of processes in the atherosclerotic deposits themselves, for example the question whether cell death is controlled in a circadian fashion.
Source: https://www.sciencedaily.com/releases/2018/05/180531142944.htm
Carla Winter, et. al. Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metabolism, 2018 DOI: 10.1016/j.cmet.2018.05.002
(Score: 1, Interesting) by Anonymous Coward on Wednesday June 06 2018, @12:26AM (4 children)
Where's the damn takeaway?
(Score: 0) by Anonymous Coward on Wednesday June 06 2018, @01:52AM
Try https://www.grubhub.com/ [grubhub.com]
(Score: 1, Funny) by Anonymous Coward on Wednesday June 06 2018, @01:58AM
You have physical damage. No drug can cure this. You need a circulatory system transplant.
Spend the extra money to get the whole thing done, including capillaries. Don't skimp or wimp out. You wouldn't want a failure anywhere. Demand that the surgeon get all the little ones in your brain, testicles, spine, tooth pulp, retinas... EVERYTHING.
(Score: 0) by Anonymous Coward on Wednesday June 06 2018, @02:32AM
See frojack's response below
(Score: 2) by JoeMerchant on Wednesday June 06 2018, @03:34AM
Ask your doctor about circadian regulation of atherosclerotic deposits for improved therapeutic intervention.
In another 20-30 years, they might roll out a clinical treatment that benefits from this research.
Україна досі не є частиною Росії Слава Україні🌻 https://www.pravda.com.ua/eng/news/2023/06/24/7408365/
(Score: 5, Informative) by frojack on Wednesday June 06 2018, @12:52AM (1 child)
I saw this article on a different source, and couldn't understand why they were talking about circadian rhythms in conjunction with atherosclerosis. It took a long time for them to get to the point.
So circadian patterns can be used for timed therapeutic intervention.
Take your meds at a certain time of day, and you need less of them, and they are more effective.
Time of day is important for other drugs, like cholesterol meds, (for example Crestor), because cholesterol is made by the liver as you sleep, so taking the meds at night is more effective.
But this study promises a more fine grained control of time and location: only into atherosclerotic areas!!
No, you are mistaken. I've always had this sig.
(Score: 2) by JoeMerchant on Wednesday June 06 2018, @03:36AM
I think it's even better than that... reduction of side effects means that you can take much more effective doses of meds during the cheeseburger removal hour:
Україна досі не є частиною Росії Слава Україні🌻 https://www.pravda.com.ua/eng/news/2023/06/24/7408365/