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posted by martyb on Monday September 17 2018, @08:18PM   Printer-friendly
from the old-man-with-young-blood-[vessels] dept.

New Atlas:

Diet trends like intermittent fasting and ketogenesis are proving wildly popular for their rapid weight-loss effects, but scientists are also starting to uncover how they might benefit the body in other, longer term ways. Case in point: a molecule produced during fasting has now been found to apply the brakes to aging of the vascular system, a process closely tied to the aging of the human body as a whole.

When the body enters ketosis, a metabolic state induced by fasting and low-carb diets, it turns to the body's stored fats for energy, rather than glucose. One of these sources of energy, known collectively as ketones, is a molecule called β-Hydroxybutyrate.

"Previously, studies on ketone bodies focused on energy metabolism, but this study showed that there are other physiological effects which regulate cell cycle to retardate aging progression," study senior author Dr. Ming-Hui Zou tells New Atlas.

The more you starve, the longer you live.


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  • (Score: 0) by Anonymous Coward on Monday September 17 2018, @08:27PM (6 children)

    by Anonymous Coward on Monday September 17 2018, @08:27PM (#736161)

    The more you starve, the longer you live.

    There is no starving involved. The way it works is that you need to consume less calories to feel full. Its really not so hard to try it for a week and have your eyes opened to the totally wrong impression about the relationship between diet and weight youve been given by nutrition researchers and public health advocates.

    • (Score: 0) by Anonymous Coward on Monday September 17 2018, @08:38PM (5 children)

      by Anonymous Coward on Monday September 17 2018, @08:38PM (#736167)

      And lets look at the paper. From the graphical abstract and caption I see they want to claim:

      b-hydroxybutyrate prevents vascular cell senescence via inducing cell quiescence. b-hydroxybutyrate-induced vascular cell quiescence is dependent on Oct4 expression, which is upregulated by forming hnRNP A1 complex with Oct4 mRNA. b-hydroxybutyrate-induced Oct4 expression is negatively correlated with hallmarks of vascular senescence in vivo.

      Then I would expect a scatter plot of "beta-hydroxybutyrate" levels vs "vascular cell senescence" as the first figure, or at least somewhere in the paper (and scatter plots of the rest of the relationships they've drawn conclusions about in later figures).

      I don't see it, so study fails my heuristic and will be ignored.

      • (Score: -1, Spam) by Anonymous Coward on Monday September 17 2018, @08:52PM

        by Anonymous Coward on Monday September 17 2018, @08:52PM (#736176)

        What a bizarre sight. Having never witnessed something so strange before, little Eric could only stare blankly as the man slithered towards him. Yes, that's right: "slithered."

        A man was lying face-first on the sidewalk and somehow slithering towards the boy like a snake. This man, who was bald and obese, did not appear to be in any pain, despite the fact that he was sliding across rough cement. Just what was going on here? As little Eric was pondering that very question, he did not even notice that the man's head had bumped into his feet. Then, in accordance with the man's iron will, everything changed.

        Several separate but simultaneous changes happened in an instant. One, Eric's body was instantly repositioned such that he was lying face-first on the sidewalk. Two, all of Eric's clothing vanished. Three, Eric could no longer move, as if he was paralyzed. Startled by these sudden events, Eric barely noticed that the man had slithered on top of his body. Or, at least, he didn't notice until it entered his body...

        "No! Stoooooooooooop! It huuuuuuuuuuuuuuuuuuuuuuuuurts!" Eric screamed. A hard, thick object had entered the boy's anus. This object was rapidly being slammed into and then pulled out of Eric's hole. Even the word "brutal" would be an understatement here; it was as if the kid's anus was being torn apart, to the point where it was bleeding profusely. Although the boy screamed for mercy, the man said nothing and simply continued pumping.

        Yes, he pumped. The man pumped even when Eric screamed. The man pumped even when Eric sustained several anal fissures. The man pumped, until everything was squirted inside. And then, it was over.

        For a moment, and even though he was still in massive pain, Eric was relieved. Perhaps the man had finally been satisfied, and he would leave the boy alone. Indeed, the man had no further interest in Eric, having utilized the boy thoroughly. However, as the man was slithering off of Eric's body, the kid's head snagged on one of the man's many fat rolls and his neck snapped instantly. That was the end of little Eric.

        The man slithered into the sunset without a care in the world. His destination was a world in which freedom prevailed. For without freedom - without men's rights - all would be lost.

      • (Score: 0) by Anonymous Coward on Monday September 17 2018, @09:11PM (3 children)

        by Anonymous Coward on Monday September 17 2018, @09:11PM (#736191)

        You want science in your dietary "science"? How the hell are you going to sell books and mail order meal plans if you have to back that shit up with actual science! And here I thought we were supposed to be eating all we wanted of just cheese and bacon to live a long, healthy life. What ever happened to THAT idea?

        • (Score: 1, Informative) by Anonymous Coward on Monday September 17 2018, @09:21PM (2 children)

          by Anonymous Coward on Monday September 17 2018, @09:21PM (#736197)

          And here I thought we were supposed to be eating all we wanted of just cheese and bacon to live a long, healthy life. What ever happened to THAT idea?

          Nothing happened to this idea, its just that you read it wrong.

          Actually, "all you wanted of cheese and bacon" depends on if you eat a lot of carbs or not. In fact, if you keep carbs low enough, you will sometimes need to force yourself to eat anything at all, just because cravings drop so low your rational mind starts controlling your eating behavior. Its not hard or expensive to test for yourself and I'm not saying it works for everyone (I never really craved sweets anyway)...

          • (Score: 3, Informative) by suburbanitemediocrity on Monday September 17 2018, @10:00PM (1 child)

            by suburbanitemediocrity (6844) on Monday September 17 2018, @10:00PM (#736230)

            I've experimented with this and my experience is similar to yours. But then a friend brought up a point from when he lived in a third world country. He said the food he ate was good, but it was the same thing (cornmeal paste) for every meal, every day. After a few days, you only ate when you were really hungry. He'd take a few bites, not be hungry anymore and stop eating. Similarly, eating only meat and cheese also gets old, although it might take a little longer as there is still variety there.

            • (Score: 0) by Anonymous Coward on Monday September 17 2018, @10:13PM

              by Anonymous Coward on Monday September 17 2018, @10:13PM (#736239)

              There is plenty of variety allowed, just eat a eggs/cheese/salad/fish/steak/chicken mix. Just "no grains, no sugar" (you still get some from your vegetables and whatever fruit you eat as desert). And I'm totally open to the idea the grain supply is messed with or poisoned somehow, so it isnt actually consuming carbs per se.

              But it is an interesting anecdote you are relating and I'd love to hear more details. Where can I get something like this "cornmeal paste"?

  • (Score: 3, Funny) by The Mighty Buzzard on Monday September 17 2018, @09:41PM (8 children)

    by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Monday September 17 2018, @09:41PM (#736216) Homepage Journal

    Life without biscuits and gravy isn't living, it's just fleeing death.

    --
    My rights don't end where your fear begins.
    • (Score: 0) by Anonymous Coward on Monday September 17 2018, @10:18PM (7 children)

      by Anonymous Coward on Monday September 17 2018, @10:18PM (#736244)

      Who said you have to go without? Just start with eating less than 700 g of carbs per week. So you can eat a couple of those, but (probably) won't even want to bother making/ordering them once you try it. Sugar is an addictive white powder, it was considered a drug until very recently.

      • (Score: 4, Funny) by Anonymous Coward on Monday September 17 2018, @10:53PM (2 children)

        by Anonymous Coward on Monday September 17 2018, @10:53PM (#736262)

        You millennials are a hoot. Twenty years from now, you'll realize that carbohydrates are an essential factor in human diet and reducing them is what resulted in your generation's gender confusion. But by then it well be too late.

        • (Score: 0) by Anonymous Coward on Monday September 17 2018, @11:04PM (1 child)

          by Anonymous Coward on Monday September 17 2018, @11:04PM (#736268)

          Yea the food pyramid you were brainwashed with was right all along, and somehow the spread of free info about diet on the internet in the last few years is responsible for "millennial" behavior going back decades earlier. Just keep letting the govenerment pump you full of whatever they want...

          • (Score: 0) by Anonymous Coward on Monday September 17 2018, @11:42PM

            by Anonymous Coward on Monday September 17 2018, @11:42PM (#736284)

            c'mon it's obviously a satirical post, gender identity and carbs? lol

      • (Score: 5, Insightful) by The Mighty Buzzard on Tuesday September 18 2018, @02:33AM (3 children)

        by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Tuesday September 18 2018, @02:33AM (#736343) Homepage Journal

        Kid, what's in fashion diet-wise changes every couple years. Adult long enough and you'll notice this too. The truth is human beings can eat damned near anything short of hubcaps and get along just fine. That's what omnivores do.

        --
        My rights don't end where your fear begins.
        • (Score: 4, Touché) by coolgopher on Tuesday September 18 2018, @05:43AM (1 child)

          by coolgopher (1157) on Tuesday September 18 2018, @05:43AM (#736397)

          ...just not get along *with each other*.

          • (Score: 3, Touché) by The Mighty Buzzard on Tuesday September 18 2018, @10:51AM

            by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Tuesday September 18 2018, @10:51AM (#736453) Homepage Journal

            Having functionally wiped out most of the multi-cellular lifeforms that are worth fighting and lacking any extraterrestrial lifeforms to fight, we've no choice but to turn to our most ancient enemy, humans.

            --
            My rights don't end where your fear begins.
        • (Score: 0) by Anonymous Coward on Tuesday September 18 2018, @05:59AM

          by Anonymous Coward on Tuesday September 18 2018, @05:59AM (#736401)

          Those fads are mostly government approved, this one is not but easy enough for people to prove to themselves.

  • (Score: 2) by Snotnose on Monday September 17 2018, @11:59PM (2 children)

    by Snotnose (1623) on Monday September 17 2018, @11:59PM (#736292)

    That same molecule will kill you faster than a slumdog Chicagoan with a 9mm.

    --
    Why shouldn't we judge a book by it's cover? It's got the author, title, and a summary of what the book's about.
    • (Score: 2) by Hyperturtle on Tuesday September 18 2018, @03:19PM (1 child)

      by Hyperturtle (2824) on Tuesday September 18 2018, @03:19PM (#736546)

      You're funny.

      Gamma-hydroxybutyrate has a lot of health benefits, but it also had non-naturally produced competitors. It can't kill anyone, perhaps unfortunately for those pushing that narrative, unlike prescription opiods.

      And like any useful drug, it had abuse potential, and people did abuse it. What abuse means depends on the narrative, though. I won't get into that, as it's off-topic.

      The profit motive for already patented medicines that competed in the same space (the drug can do a number of nice things when used appropriately), coupled with a good means to wield fear for propaganda purposes, effectively killed the medical research in the USA for this drug. I think its mostly used by weight lifters mostly now, primarily for the growth hormone it creates- sort of like how there is a market for anabolic steroids amongst the same crowd.

      It used to be available over the counter or at health food/supplement stores, but that era is long gone.

      Anyway this is not news, as to what the article states. GHB has been known for its active part of the Krebs energy cycle, as specific to the production of energy in the body such as when utilizing ketones. That is applicable for those on keteogenic diets. This was mostly hyped up during the Atkin's diet era, but got pushed aside due to the anti-drug hysteria around the same time. I guess it's time to dust off the means to try to sell small supplements for it, perhaps with a patented secret recipie.

      The same market of consumers will buy it just like they used to (if perhaps not the same people, just that demographic), except I'd imagine it'd cost 4x as much, at least if it's a retail supplement.

       

      • (Score: 2) by Hyperturtle on Tuesday September 18 2018, @04:07PM

        by Hyperturtle (2824) on Tuesday September 18 2018, @04:07PM (#736573)

        whoops looks like I mixed up 1 2 and 3. (alpha beta gamma etc)... I mistook the s set for gamma for some reason. After doing something else, the thought popped in there that I misread the molecule. The article itself did not mention alpha, beta, or gamma directly in those words, and so my bad.

        Check out wikipedia for some differences. Beta and gamma have more similarities than alpha and beta or alpha and gamma.

        https://en.wikipedia.org/wiki/Hydroxybutyrate [wikipedia.org]

        You can drill into the respective pages for each to see how hydroxybutyrates in general have a lot of helpful attributes. Probably, they should all get a bit more positive press, but no one does that for free.

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