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posted by chromas on Thursday January 10 2019, @02:30PM   Printer-friendly

Submitted via IRC for takyon

Engineers create an inhalable form of messenger RNA

Messenger RNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far has been finding safe and efficient ways to deliver mRNA molecules to the target cells.

In an advance that could lead to new treatments for lung disease, MIT researchers have now designed an inhalable form of mRNA. This aerosol could be administered directly to the lungs to help treat diseases such as cystic fibrosis, the researchers say.

[...] The researchers showed that they could induce lung cells in mice to produce a target protein — in this case, a bioluminescent protein. If the same success rate can be achieved with therapeutic proteins, that could be high enough to treat many lung diseases, the researchers say.

[...] The particles the team created consist of spheres, approximately 150 nanometers in diameter, with a tangled mixture of the polymer and mRNA molecules that encode luciferase, a bioluminescent protein. The researchers suspended these particles in droplets and delivered them to mice as an inhalable mist, using a nebulizer.

[...] The researchers found that 24 hours after the mice inhaled the mRNA, lung cells were producing the bioluminescent protein. The amount of protein gradually fell over time as the mRNA was cleared. The researchers were able to maintain steady levels of the protein by giving the mice repeated doses, which may be necessary if adapted to treat chronic lung disease.


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  • (Score: 0) by Anonymous Coward on Thursday January 10 2019, @02:38PM (9 children)

    by Anonymous Coward on Thursday January 10 2019, @02:38PM (#784497)

    This is basically just a virus

    • (Score: 2) by Runaway1956 on Thursday January 10 2019, @03:28PM (3 children)

      by Runaway1956 (2926) Subscriber Badge on Thursday January 10 2019, @03:28PM (#784514) Journal

      Yeah, man, but how does it compare to Testors model airplane glue?

      • (Score: 2) by JoeMerchant on Thursday January 10 2019, @04:11PM (1 child)

        by JoeMerchant (3937) on Thursday January 10 2019, @04:11PM (#784529)

        Party Eyes! Luciferase encoding mRNA eyedrops, make your eyes glow green for the weekend.

        --
        🌻🌻 [google.com]
        • (Score: 0) by Anonymous Coward on Thursday January 10 2019, @04:19PM

          by Anonymous Coward on Thursday January 10 2019, @04:19PM (#784533)

          Not even interesting, man. My mom gave me green eyes, and my girl gave me a green penis.

      • (Score: 0) by Anonymous Coward on Thursday January 10 2019, @06:15PM

        by Anonymous Coward on Thursday January 10 2019, @06:15PM (#784600)

        Real Men(tm) use aircraft dope.

    • (Score: 3, Insightful) by ikanreed on Thursday January 10 2019, @04:55PM (4 children)

      by ikanreed (3164) Subscriber Badge on Thursday January 10 2019, @04:55PM (#784546) Journal

      Lacking the self-duplication that a virus has, yes.

      • (Score: 0) by Anonymous Coward on Thursday January 10 2019, @05:13PM (3 children)

        by Anonymous Coward on Thursday January 10 2019, @05:13PM (#784559)

        Fine, a replication defective rna virus: https://en.m.wikipedia.org/wiki/Defective_interfering_particle [wikipedia.org]

        • (Score: 2) by ikanreed on Thursday January 10 2019, @05:39PM (2 children)

          by ikanreed (3164) Subscriber Badge on Thursday January 10 2019, @05:39PM (#784570) Journal

          That seems sufficiently different to not warrant fear or concern.

          By way of car analogy, "A parking spot is like a slow, no-impact car accident"

          • (Score: 1, Interesting) by Anonymous Coward on Thursday January 10 2019, @05:54PM (1 child)

            by Anonymous Coward on Thursday January 10 2019, @05:54PM (#784581)

            Well these mice are probably living in a sterile environment, how long in the real world until the mRNA gets packaged up into an infectious particle due to coinfection with a flu/etc virus?

            • (Score: 4, Interesting) by ikanreed on Thursday January 10 2019, @07:02PM

              by ikanreed (3164) Subscriber Badge on Thursday January 10 2019, @07:02PM (#784614) Journal

              About the same rate as any other gene in your genome, i.e. startlingly low, and frequently destructive to the virus. I rule your concern: technically possible.

  • (Score: 2) by maxwell demon on Thursday January 10 2019, @07:11PM

    by maxwell demon (1608) on Thursday January 10 2019, @07:11PM (#784619) Journal

    So you can instruct the lung cells to produce virtually any protein? So how long until someone figures out to make "recreative mRNA"?

    "No officer, I didn't take drugs, my lung produced them themselves; there's nothing in the law forbidding body cells from producing stuff!"

    --
    The Tao of math: The numbers you can count are not the real numbers.
  • (Score: 0) by Anonymous Coward on Thursday January 10 2019, @09:34PM

    by Anonymous Coward on Thursday January 10 2019, @09:34PM (#784679)

    This sounds scary. I sure hope it isn't easily airborne and requires a pretty direct inhaler.

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