Submitted via IRC for Bytram
The findings, published this week in Nature Communications, suggest that, although heavy drinking is a prerequisite for AUD, variants in several genes -- DRD2 and SIX3, for example -- may need to be present for people to develop AUD.
"This study has revealed an important genetic independence of these two traits that we haven't seen as clearly before," said Henry R. Kranzler, MD, a professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania, and first author of the study. "Focusing on variants only linked to AUD may help identify people at risk and find targets for the development of medications to treat it. The same applies to alcohol consumption, as those variants could inform interventions to help reduce consumption in heavy drinkers, who face their own set of adverse effects."
[...] Environmental, hereditary, and genetic factors all play a role in AUD; however, many of the variants across the genome believed to be associated with the disorder remain to be identified.
For the study, the researchers used genetic data from the multi-ethnic Million Veteran Program (MVP), a national, voluntary research program sponsored by the Department of Veterans Affairs, which includes white, African-American, Latino, and Asian participants. The diverse study sample is notable, in that it included more than 50,000 African-Americans, one of the largest genome-wide studies of this population. Scores from the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) screenings and AUD diagnoses were obtained from the same population (a total of 274,424 people) to conduct the GWAS for the two traits. The researchers also analyzed other data from health records to look for correlations between genes and diseases, as well as other non-alcohol related traits.
(Score: 2, Funny) by Anonymous Coward on Thursday April 04 2019, @05:32PM (23 children)
I'm guessing Rust or Go, or possibly S/370 Assembler would be best for developing AUD*, given that those languages pretty much require heavy drinking anyway.
Also, I think it's great that a journal like Nature Communications is weighing in on programming languages!
*What, pray tell, is AUD? Do I really have to read TFA?
(Score: 0) by Anonymous Coward on Thursday April 04 2019, @05:33PM (1 child)
alcohol use disorder
(Score: 2) by DannyB on Thursday April 04 2019, @06:12PM
disordered alcohol use
Depending on your programming language.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 1, Informative) by Anonymous Coward on Thursday April 04 2019, @05:34PM (10 children)
From TFS:
And I thought literacy was overrated.
Never mind.
--Emily Litella
(Score: 3, Touché) by DannyB on Thursday April 04 2019, @05:56PM (4 children)
That's almost at the end of the last paragraph. You must have amazing reading stamina.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 2) by aristarchus on Thursday April 04 2019, @06:11PM (3 children)
But the "AUD" from "AUDIT-C" may not be the same AUD when it stands alone. The Latin root is audio,
https://en.wiktionary.org/wiki/audio#Latin [wiktionary.org]
(Score: 2) by realDonaldTrump on Thursday April 04 2019, @06:36PM
Thank you, so interesting. And possibly that's where the word Audism comes from. Who knows!!!
(Score: 0) by Anonymous Coward on Thursday April 04 2019, @08:03PM (1 child)
Mr. Aristarchus,
I find your ideas interesting and would like to subscribe to your newsletter.
(Score: 2) by aristarchus on Thursday April 04 2019, @10:15PM
https://physics.weber.edu/carroll/Archimedes/sand.htm [weber.edu]
(Score: 2, Interesting) by Anonymous Coward on Thursday April 04 2019, @06:01PM (4 children)
Literacy? Literacy is putting the definition of the acronym first -- pedantic but incorrect morons put it anywhere. Behold:
(Score: 2) by NotSanguine on Thursday April 04 2019, @07:58PM (3 children)
The funny part about this is that while your assessment WRT the use of acronyms is quite correct, in this case your implication that the author is illiterate appears to be incorrect.
While TFS quotes a *portion* of the abstract, there is a summary in TFA, *before* said abstract, that states (in the first sentence, no less):
So it turns out that the author(s) did use the acronym correctly.
And thank you very much for sparking my curiosity. Not! Now I'm filled with murderous rage because your screed actually made me read TFA. A pox on both your houses, you insensitive clod! :)
No, no, you're not thinking; you're just being logical. --Niels Bohr
(Score: 2) by hemocyanin on Thursday April 04 2019, @08:12PM (2 children)
The issue is that the deficit in TFS was so glaring, some people decided to just skip TFA.
For you, it had the opposite effect though. ;-)
The question is then, will a bad summary cause more people to avoid the topic out of annoyance, or more people to investigate the topic out of annoyance. I'm sure writers of clickbait have a deeper insight on this than I do, but I would prefer a nice, neat, clean, informative summary.
(Score: 2) by NotSanguine on Thursday April 04 2019, @08:34PM (1 child)
For me, that's dependent on several factors:
Am I in a rush?
Does what I can see make me want to see more?
Do the *comments* engage me enough to take a look?
Ooh! Look! Shiny! And I'm off to something else?
In this case, I was confused about the meaning of AUD in this context.
While you didn't (or did you?) read TFA, you did choose to engage on this topic. What factors made you decide to engage?
No, no, you're not thinking; you're just being logical. --Niels Bohr
(Score: 2) by hemocyanin on Thursday April 04 2019, @09:39PM
Annoyance caused me to engage and a lack of personal meaningfulness regarding the topic probably induced me to engage as I did. If TFS had been clean and clear, I probably would not have engaged at all (neither I nor anyone I know has an alcohol problem). The genetic component was of enough interest to me to read TFS, but the opaque nature of TFS caused my annoyance (I did not RTFA) and I then came to comment on a tangent to a story I would likely never have commented on at all if TFS was well done.
If Soylent's sole purpose was feeding advertising to eyeballs, TFS as written would have been a win but if it had been written well, it would be a loss to an advertising focused site because I would not have clicked.
(Score: 3, Insightful) by hemocyanin on Thursday April 04 2019, @05:51PM (8 children)
I totally got sidetracked on that question too. My emotional response to that sort of annoyance is interesting -- first I re-read the first two paragraphs a couple times and felt annoyed, then I looked at the link to TFA and hesitated then decided "screw that", and became more annoyed. I decided to see if there was a comment explaining AUD and if not, write a small rant about it. On seeing your rant, I felt instantly better -- "it isn't just me" and now I'm no longer annoyed. Also, opening up comments also brought the third paragraph into center view and I notice that there is enough at the end to make an assumption about AUD. I also found the answer to the original question as a response to your post, but the truth is, I just don't GAF about AUD anymore.
It is interesting how the way something is written had so much impact on me.
(Score: 3, Touché) by takyon on Thursday April 04 2019, @05:55PM
Commence drinking.
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: 2) by Freeman on Thursday April 04 2019, @06:20PM (1 child)
I'm here to point out the irony of your complaining about the summary / article not providing proper introduction of their abbreviations and you doing it twice in your post.
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: 2) by hemocyanin on Thursday April 04 2019, @08:07PM
But that's the point -- I don't care anymore. I'm not going to read substantive comments. I'm not going to read TFA. I realize this is irrational and I don't care. It does however, serve as a reminder to me for things I care about, to focus on clarity.
(Score: 1) by DECbot on Thursday April 04 2019, @06:22PM (4 children)
If you were drinking at the time, you would likely have AUADHD.
cats~$ sudo chown -R us /home/base
(Score: 0) by Anonymous Coward on Thursday April 04 2019, @09:42PM (3 children)
good sig
(Score: 1) by DECbot on Friday April 05 2019, @12:20AM (2 children)
Thanks
Sometimes I wonder if people still get the reference.
cats~$ sudo chown -R us /home/base
(Score: 2) by Magic Oddball on Friday April 05 2019, @05:47AM
I recognized it right away; I'd be surprised if anyone who was 12-30 and online back in 2000 wouldn't.
(Score: 0) by Anonymous Coward on Friday April 05 2019, @10:33PM
But, but, it's not presented to me as a link so I can see what it means. And Google doesn't provide any relevant hits, nor does unix.stackexchange.com. Forcing me to use my brain to parse that command line. I hate you!
More seriously, if you *really* want it to be "All your base," shouldn't you do something like:
cats~$ sudo chown -R us `find /home -type d -name [Bb][Aa][Ss][Ee]`
BTW, I'm full of good ideas like that! i can give you tips on flossing, grooming your pets and making your relationships more satisfying. When do I start?
(Score: 4, Funny) by DannyB on Thursday April 04 2019, @05:53PM
> What, pray tell, is AUD?
Google helps: Australia Dollar, which today is 0.71 US dollar.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 4, Interesting) by DannyB on Thursday April 04 2019, @06:10PM (4 children)
Do these genes have any relation to other substance abuse or addiction? Recreational or excessive drug use either illegal or prescription?
I have wondered how much heredity plays a role.
I know that in my wife's family there is joking about a tendency to engage in alcohol excessively, and some alcoholism and drug use that I know of.
None that I am aware of in my family. I also am a non drinker. It has never appealed to me. I occasionally take prescription narcotics, for over ten years, for a type of arthritis. I have never even been tempted to overuse it. In fact, the opposite, I have a healthy fear of taking it. Yet some people can't help themselves.
If I have a vice it is that I like food too much. :-) Even that loses its appeal as I get older.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 2) by realDonaldTrump on Thursday April 04 2019, @06:51PM (3 children)
Freddy -- my older brother, magnificent guy -- loved drinking. And it killed him at an early age. He said to me, "Donald, never drink." I've never drank alcohol. Never smoked tobacco. And never touched coffee. Because I don't want to end up like him. If you could imagine a 7th. Day Adventist that loves burgers and Diet Coke, and goes to Church on Sundays, that's me. Pushing my beautiful red Diet Coke Button right now!!!!
(Score: 0) by Anonymous Coward on Thursday April 04 2019, @07:00PM
Diet Coke is horrible, but what's even more horrible is Pepsi Max.
(Score: 2) by DannyB on Thursday April 04 2019, @09:59PM
I hadn't even thought about Tobacco and Diet Coke.
I don't do Tobacco. I only have two cans of Diet Coke in the morning -- about 1 cup of coffee worth of caffeine. My best friend was shocked that I don't take more caffeine than that.
(and I'm not Mormon. or SDA for that matter) I don't avoid alcohol, tobacco, caffeine, etc for religious reasons -- although it allows me to look down on and judge other people. Just as Jesus taught.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 2) by chromas on Saturday April 06 2019, @06:11AM
Fake news! SDAs go to church on Saturday.
(Score: 0) by Anonymous Coward on Thursday April 04 2019, @06:42PM (4 children)
All humans have the right to be DNA tested for these genes and get personalized healthcare.
(Score: -1, Troll) by Anonymous Coward on Thursday April 04 2019, @09:55PM
What about Muslims?
(Score: 2) by DannyB on Thursday April 04 2019, @10:02PM (2 children)
All humans have the right to a government mandated DNA test. And to hope that they get a passing grade. According to government mandated minimum standards.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 2) by mhajicek on Friday April 05 2019, @02:08AM (1 child)
Sorry, your insurance will cost ten times as much due to your predispositions.
The spacelike surfaces of time foliations can have a cusp at the surface of discontinuity. - P. Hajicek
(Score: 2) by DannyB on Friday April 05 2019, @02:58PM
Maybe you missed the part about hoping you get a passing grade on your government mandated DNA test.
Young people won't believe you if you say you used to get Netflix by US Postal Mail.
(Score: 2, Interesting) by Anonymous Coward on Thursday April 04 2019, @09:49PM (1 child)
Did this genetic variation exist before the alcoholism, or was it brought about by the alcoholism?
(Score: 1) by patricepetticoat on Thursday April 04 2019, @11:26PM
I am trying to find the value in this comment. Its either really stupid or really smart.