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posted by chromas on Wednesday April 17 2019, @12:57AM   Printer-friendly
from the No,-I'm-storing-up-potential-iPSCs dept.

According to an article in the journal Advanced Science, researchers at Tel Aviv University were able to create a small 3D-printed heart that included blood vessels out of human tissue.

Until now, researchers have only been able to print simple tissues lacking blood vessels, so a 3D, fully vascularized engineered heart is a step in the right direction.

The process consists of taking a sample of abdominal fat tissue, reprogramming the cells to become induced pluripotent stem cells (iPSCs), differentiating these into cardiac muscle cells and blood vessel cells, and combining them with hydrogels to form structures for the cells to proliferate on.

Heart disease causes one in four deaths in the US (about 610,000 people a year), and there's a shortage of heart donors for transplants, so 3D-printed hearts could help solve a major issue

As a next step, the team plans to culture, print, and transplant similar hearts into animals. Significant challenges still remain, such as the efficient cultivation of the stem cells to gain the large quantity needed to engineer full-size organs and improvement of the blood vessel network demonstrated; the team indicates we are many, many years from from doing this for humans.


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  • (Score: 0, Flamebait) by Ethanol-fueled on Wednesday April 17 2019, @01:00AM

    by Ethanol-fueled (2792) on Wednesday April 17 2019, @01:00AM (#830748) Homepage

    So they can finally make their own and sell those rather than trafficking everybody else's? Good job Israel, you are awesome!

  • (Score: 2) by Runaway1956 on Wednesday April 17 2019, @01:08AM (3 children)

    by Runaway1956 (2926) Subscriber Badge on Wednesday April 17 2019, @01:08AM (#830753) Journal

    All the medical breakthroughs, just in time to keep Baby Boomers alive for another 25 years! You millenials should be grateful!

    • (Score: 0) by Anonymous Coward on Wednesday April 17 2019, @01:11AM (1 child)

      by Anonymous Coward on Wednesday April 17 2019, @01:11AM (#830756)

      And can clone MDC so the one who passed on was simply a duplicate and the real one travelled to the future to write more soylent posts when you are all crotchety Methuselahs :)

      • (Score: 0) by Anonymous Coward on Wednesday April 17 2019, @02:29AM

        by Anonymous Coward on Wednesday April 17 2019, @02:29AM (#830789)

        I thought the rDT was the only one all crotchety.

    • (Score: 0) by Anonymous Coward on Wednesday April 17 2019, @01:12AM

      by Anonymous Coward on Wednesday April 17 2019, @01:12AM (#830757)

      I am grateful. The mid-life crises of today's 40-60 year olds are of direct benefit to younger people. I hope they continue to push the envelope.

  • (Score: 0) by Anonymous Coward on Wednesday April 17 2019, @01:10AM

    by Anonymous Coward on Wednesday April 17 2019, @01:10AM (#830755)

    Where they 3D print her body based only on the hand, now one step closer closer to reality, that is so cool

  • (Score: 2) by JoeMerchant on Wednesday April 17 2019, @01:33AM (2 children)

    by JoeMerchant (3937) on Wednesday April 17 2019, @01:33AM (#830772)

    How's the neural conduction? Valving? Does this Frankenheart pump even 30% of what a real heart can do? And, how long does it maintain cohesion of the structure (i.e. when do the cells start growing outside the scaffolding?)

    Vascularization is certainly progress, but call me when the heart lasts longer than the post-surgical recovery period: 6 months+ for a cracked chest procedure, IIRC.

    --
    🌻🌻 [google.com]
  • (Score: 4, Interesting) by Pslytely Psycho on Wednesday April 17 2019, @02:01AM (5 children)

    by Pslytely Psycho (1218) on Wednesday April 17 2019, @02:01AM (#830782)

    I see they haven't figured out how to print nerves yet.
    After I wrote that sentence, I thought, how the hell does a heart transplant work since all the nerves had been cut. Apparently, the nerves degenerate immediately and the heart just runs on autopilot. They can't feel angina or other heart problems.
    Just about 70% will eventually see new nerve growth however over a long period of time.
    So yeah, they have to learn to print nerves unless they intend this to be bio-mechanical in some way.

    The article I read after writing the initial sentence, it's a bit out of most of our fields, but is still fairly easy to interpret. I found it a fascinating read on a subject I have only passing familiarity with. (Once trained as a Medical Assistant. Then Hillary Clinton, the day Bill was elected said "health care reform." No one knew what it would entail, and the jobs dried up for about two years and I became a mechanic instead. My tale of woe for your entertainment)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210323/ [nih.gov]

    --
    Alex Jones lawyer inspires new TV series: CSI Moron Division.
    • (Score: 2) by Farkus888 on Wednesday April 17 2019, @03:09AM (4 children)

      by Farkus888 (5159) on Wednesday April 17 2019, @03:09AM (#830806)

      OT reply to your signature but... Nixon is a great case of one big mistake at the end being all you are remembered for. The arch evil republican's time saw title 9, the EPA, the Civil rights act and the end of the Vietnam War for example. I'm not a supporter by any means, but Trump is not nearly as bad as many predicted. Even still your comparison is unfair to Nixon. How many minutes of warrantless recordings did the NSA make during Obama or Trump's time? Definitely more than 13.

      • (Score: 2) by Pslytely Psycho on Wednesday April 17 2019, @04:57AM

        by Pslytely Psycho (1218) on Wednesday April 17 2019, @04:57AM (#830832)

        I will give Nixon credit where credit is due, but no, I respectfully disagree with you, on both Nixon and Trump.
        I will say that Nixon made Social Studies classes far more interesting than they would of been without him though. (I was in high school at the time.)
        For the record, there were over3000 hours of tapes made, (voice activated) 18 1/2 minutes were 'missing' and his secretary said she was not responsible for the final 13 minutes. They weren't warrentless, the system was installed in 1971 and was not a secret to Nixon as he approved the installation.
        The Watergate break-in was simply the culmination of a drunken, paranoid man who was afraid he'd lose an election he won in a landslide. He fucked himself, the tapes also revealed a lot of other inappropriateness within his administration.

        Peace out!

        --
        Alex Jones lawyer inspires new TV series: CSI Moron Division.
      • (Score: 2) by Pslytely Psycho on Wednesday April 17 2019, @07:17AM (2 children)

        by Pslytely Psycho (1218) on Wednesday April 17 2019, @07:17AM (#830899)

        Also remember that Nixon widened the scope of the Vietnam war (police action officially) by invading Cambodia without authorization or telling his chiefs of staff (1970).
        He also oversaw the Kent State Massacre where American National Guardsmen fired on American College Students on American soil for protesting the war, resulting in 3 dead and 9 wounded (also 1970).

        He is remembered by those of us who lived through it for much more than a third-rate burglary. He used the FBI, CIA and IRS against his perceived enemies. He practically wrote the book on abuse of power. Secretly bombed Cambodia long before the invasion while claiming we weren't in Cambodia. There were wiretaps, money laundering, extortion.

        And Nixon as well, believed that Executive Privilege protected him from having to release the tapes he made to the Grand Jury.
        He was wrong.

        Tricky Dick Nixon earned his nickname and scorn.
        Trump is an amateur by comparison.

        Sorry to run into two posts but you kind of triggered a lot of bad memories of that time period. I lost several relatives to the Vietnam war (one in Cambodia when we weren't there). It was not a good time for America nor my personal life.

        --
        Alex Jones lawyer inspires new TV series: CSI Moron Division.
        • (Score: 2) by Farkus888 on Wednesday April 17 2019, @08:08PM (1 child)

          by Farkus888 (5159) on Wednesday April 17 2019, @08:08PM (#831282)

          I think you missed my point. If I guess correctly I'm about the age you were under Carter or early Reagan. People my age talk about Nixon like he was a cartoon villain not knowing any of the things he did wrong or right. Some of them supported Bush, many supported Obama. Those 2 treated Nixons most evil moments like an SOP. You got Cambodia, I got Iraq, Afghanistan, Syria and Pakistan. Truthfully, I know history well enough to assume the CIA is behind every coup so all of the Arab spring countries as well. Nixons recordings for the NSA revelations from Snowden. Finally Kent state vs how many schools got hit by drone strikes. In return we got none of the party line crossing actual progress. As a country we get the same shit on a bigger scale today in so many ways, yet none of the outrage.

          • (Score: 2) by Pslytely Psycho on Wednesday April 17 2019, @11:30PM

            by Pslytely Psycho (1218) on Wednesday April 17 2019, @11:30PM (#831392)

            No, I got your point, Nixon wrote the book the following administrations have used as SOP. And it does piss me off that it provokes no outrage at all nowadays.

            Historically, I think Nixon will be pointed to as the beginning of the fall.
            Thank you for your most interesting description of how later generations view the Nixon presidency. I never thought of it like that despite my love of Futurama. A cartoon. It is a shame we culturally have such a short memory and recall only one crime of a presidency that set the stage for government abuse for the nest forty plus years.

            We, at the time hoped the fact that he had self-taped literally tons of evidence that the WH was corrupt, would lead to better oversite. Instead it became the rulebook as Snowden proved many years later.

            Hey, didn't mean to come off angry or condescending, Nixon's actions which were so abhorrent when they were discovered, have, like you said, become the standard and is done openly with nary a complaint. It does get me riled up a bit.

            Thanks for an interesting perspective on it.

            --
            Alex Jones lawyer inspires new TV series: CSI Moron Division.
  • (Score: 2) by Pslytely Psycho on Wednesday April 17 2019, @02:17AM (3 children)

    by Pslytely Psycho (1218) on Wednesday April 17 2019, @02:17AM (#830786)

    https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201900344 [wiley.com]

    " Wab grown wabbit hearts! Oh, dat's gonna make dat wascally wabbit much harder to kill " - Elmer Fudd

    --
    Alex Jones lawyer inspires new TV series: CSI Moron Division.
    • (Score: 2) by takyon on Wednesday April 17 2019, @02:26AM (2 children)

      by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Wednesday April 17 2019, @02:26AM (#830788) Journal

      That's the first link in TFS.

      --
      [SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
      • (Score: 2) by MostCynical on Wednesday April 17 2019, @02:57AM

        by MostCynical (2589) on Wednesday April 17 2019, @02:57AM (#830798) Journal

        You expect close reading of TFS, now? Most people barely make it past the headline.

        --
        "I guess once you start doubting, there's no end to it." -Batou, Ghost in the Shell: Stand Alone Complex
      • (Score: 2) by Pslytely Psycho on Wednesday April 17 2019, @04:59AM

        by Pslytely Psycho (1218) on Wednesday April 17 2019, @04:59AM (#830833)

        Huh, so it is. I couldn't get that page to open earlier. I didn't notice I linked to the same page a few hour later.
        Meh, if that's the worst I do today, it will be a good day.

        --
        Alex Jones lawyer inspires new TV series: CSI Moron Division.
  • (Score: -1, Spam) by Anonymous Coward on Wednesday April 17 2019, @07:58AM

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  • (Score: 2) by Phoenix666 on Wednesday April 17 2019, @10:48AM

    by Phoenix666 (552) on Wednesday April 17 2019, @10:48AM (#830954) Journal

    Can they print...other organs, too?

    --
    Washington DC delenda est.
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