A real world safety-study of peanut oral immunotherapy (P-OIT) for peanut allergies in preschoolers resulted in ~90% of study participants safely reaching the maintenance stage of the treatment.
We are the first group to describe preschool P-OIT in a real-world multicenter setting. The treatment appears to be safe for the vast majority of patients because symptoms were generally mild and very few reactions received epinephrine; however, life-threatening reactions in a minority of patients (0.4%) can still occur.
Oral Immunotherapy consists of a lengthy process
Oral immunotherapy starts off by giving a patient a small amount of the food [they are] allergic to -- in this case, peanuts -- and then steadily increasing the amount of that food until they reach maximum dosage. This works to desensitize the person to the food to the point that it doesn't cause a dangerous, allergic reaction.
The research was done at multiple clinics across Canada on children between 9 months and five years of age.
OIT is not a cure and requires ongoing maintenance to maintain desensitization to the allergen. If the maintenance dosage is stopped resensitization may occur.
(Score: -1, Troll) by Anonymous Coward on Sunday April 21 2019, @10:08PM
Already debunked on youtube.com. Next.
(Score: 2) by aiwarrior on Sunday April 21 2019, @10:11PM (13 children)
I know it is not related, but I tried this using myself as a guinea pig so I could eat my lovely shrimps again. In my mid 20s i got allergic to grilled shrimp and whenever I eat a full dish of it, i put my guts out. I tried to slowly increase my dosage but the misery was so much and I really believed I was damaging myself so I just gave up and now only eat a bit on my birthday or special days.
There is nothing more delicious than grilled high caliber shrimp with Garlic and a touch of beer on the sauce.
God is hard on his underlings.
(Score: 1, Informative) by Anonymous Coward on Sunday April 21 2019, @10:13PM (3 children)
You have to feed it to a goat and then drink the goat milk. You get temporary immunity.
(Score: 0) by Anonymous Coward on Monday April 22 2019, @02:17AM (2 children)
Citation needed.
Are you assuming that the goat will produce antibodies that will neutralize the antigen and prevent a response?
(Score: 0) by Anonymous Coward on Monday April 22 2019, @06:34AM (1 child)
People who actually figure shit out dont waste time trying to explain it to worthless academics. The only reason to waste resources on them is if you want a government contract of some sort.
(Score: 0) by Anonymous Coward on Monday April 22 2019, @09:22PM
Let the hate flooow through you, one day you'll be able to laugh in the faces of everyone who called you "that racist shithead".
Ok, to be fair I'm assuming your racism, but statistically it is a safe bet.
(Score: 3, Interesting) by Pav on Monday April 22 2019, @02:40AM (4 children)
My brother developed a shrimp allergy (though we call them "prawns" here in Australia). Like you he loved them, and would risk a bite and suffer swollen lips and dangerously closing airway. This is how things remained for around 10 years. Later he took some kind of mussel extract during a health kick for a while, and afterwards his allergy seemed to leave him. Perhaps it was due to his repeated exposure, or perhaps the mussel extract was similar yet different enough to change his immune response somehow, but he can eat a healthy helping... though he will never have TOO many just in case.
(Score: 2) by aiwarrior on Monday April 22 2019, @08:34AM (3 children)
The thing is that my allergy seems to kick in when mixed with the garlic sauce. Same for shell fish.. For example i can eat the mussels easily also and plain cooked shrimp is ok also, because there is no sauce.
This mussels extract is interesting though. Perhaps the mechanism is the same as what they tried in the article. It very much heartens me the thought that one day I may be able to eat it again.
(Score: 2) by Pav on Monday April 22 2019, @11:08AM (2 children)
Is there some kind of preservative involved which affects you? Or does it even happen with a simple home made garlic sauce?
(Score: 2) by aiwarrior on Tuesday April 23 2019, @06:14AM (1 child)
Simple self-cut garlic sauce does it. It is weird because garlic sauce paired with meats or other foodstuff does not trigger anything.
(Score: 0) by Anonymous Coward on Tuesday April 23 2019, @11:43AM
It may be the enzymes present in raw garlic that processes some shell fish protein into an antigen that you are hypersensitive to. If you make and fully cook the garlic separately from the shrimp then you might not have a reaction.
Keep in mind that most of the flavor we associate with garlic and other alliums are the products of enzymatic break-down. This is why if you blanch scallions or roast whole garlic prior to cutting/crushing them, they won't have as much onion/garlic flavor.
Try a test where you mix a bit of raw diced garlic with raw diced shrimp prior to cooking (possibly highly allergic if the hypothesis is true) and another with pre-cooked garlic and shrimp.
(Score: 2) by Freeman on Monday April 22 2019, @04:42PM (2 children)
I ordered a vegetable egg roll from a mom'n'pop asian food place and received a shrimp one instead. Yes, it tasted good. No, I didn't finish it. Shrimp are scavengers, just like Pigs. Why consume something that feeds on dead / decaying things?
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: 3, Touché) by Taibhsear on Monday April 22 2019, @08:41PM (1 child)
Because they're delicious? Have you not heard of how plants eat?...
(Score: 2) by Freeman on Tuesday April 23 2019, @04:35PM
https://en.wikipedia.org/wiki/Pork#Disease_in_pork [wikipedia.org]
https://www.consumerreports.org/cro/magazine/2015/06/shrimp-safety/index.htm [consumerreports.org]
A "more healthy" option in meats:
https://en.wikipedia.org/wiki/Poultry#Health_and_disease_(humans) [wikipedia.org]
Even a good meats like fish, chicken, or beef can easily be unhealthy for you, depending on source and how it's prepared. Same for plants, but most of the time all plants need is a good scrub.
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: 2) by GreatAuntAnesthesia on Tuesday April 23 2019, @01:31PM
From what I understand of the resistance-building in these trials, they don't start with "reduced dosage" as in "I'll just have the small plateful then."
You start with near-homeopathic levels (measured in parts per billion) and work your way up very gradually but consistently over months or years to "I should be able to eat half a shrimp now. Probably." and eventually, hopefully, "I can eat a whole serving of them with no negative effects."
Of course, for most people with severe allergies, just getting to "I can be in the same room as someone who had some for lunch and I don't have to be rushed to hospital" is considered a good enough target.
(Score: -1, Flamebait) by Anonymous Coward on Sunday April 21 2019, @10:37PM (4 children)
So only 10% of the children has life threatening reactions or autism. Sounds like vacccines!
(Score: 1, Informative) by Anonymous Coward on Sunday April 21 2019, @10:42PM (3 children)
Read TFS. Only 0.4% required epinephrine. The rest just didn't become immune to the threat.
(Score: -1, Flamebait) by Anonymous Coward on Sunday April 21 2019, @11:04PM (2 children)
So 9.6% got autism?
(Score: 0) by Anonymous Coward on Monday April 22 2019, @12:20AM (1 child)
Another antivaxer demonstrates their intelligence. I have to wonder if not getting vaccinations makes people dumber.
(Score: 1, Informative) by Anonymous Coward on Monday April 22 2019, @12:48AM
> I have to wonder if not getting vaccinations makes people dumber.
T'other way 'round -- they start out dumb, self selected.
(Score: -1, Flamebait) by Anonymous Coward on Sunday April 21 2019, @11:31PM (2 children)
If we feed them a small amount of ham, then work up to bacon, and finally pork chops, could Muslims be cured of mahommedism?
(Score: -1, Troll) by Anonymous Coward on Monday April 22 2019, @03:06AM (1 child)
Your power over them is slipping! We can't win unless we call them Moslems!
(Score: 1, Flamebait) by aristarchus on Monday April 22 2019, @08:00AM
Islamophobe who is afraid of Muslin, and Lindsey-wooley, no doubt. But the Good Book does prohibit the wearing of garments spun of different threads! All you polyester blend people, you are going straight to hell, and many of you are probably Methodists, and some of you Muslim. My point is, do not consume fish of the sea who do not have fins nor scales, like Uni, Oysters, Lobsters, or catfish (that means YOU, TMB!), or you are going straight to hell. Best to read your Leviticus, and the relevant passages of the Quran on halal and kosher food, beyond just the pickles.
'
But my point here is that we may be holding back on this theraputic technology. Perhaps, with those who are, um somewhat constipated in their political views, we might try the anal therapy? Peanuts up their ass, until they show signs of recovery, like admitting the Hilary should have won the last presidential election. If they don't, more peanuts.
I happen to know, via second hand reports, that this is not likely to be effective therapy for Runaway1956. His assholery is near infinite, and if anyone is familiar with Mark Twain, in the beginning of the "Celebrated Jumping Frog of Calavaras County" relates the story of the bird storing acorns through a knothole in a plank in the roof of a miner's cabin. Runaway is that miner's cabin.;