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posted by Fnord666 on Tuesday February 11 2020, @01:47PM   Printer-friendly
from the turning-back-the-hands-of-time dept.

Molecular 'switch' reverses chronic inflammation and aging:

Chronic inflammation, which results when old age, stress or environmental toxins keep the body's immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer's and Parkinson's to diabetes and cancer.

Now, scientists at the University of California, Berkeley, have identified a molecular "switch" that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.

[...] In the study, Chen and her team show that a bulky collection of immune proteins called the NLRP3 inflammasome -- responsible for sensing potential threats to the body and launching an inflammation response -- can be essentially switched off by removing a small bit of molecular matter in a process called deacetylation.

Overactivation of the NLRP3 inflammasome has been linked to a variety of chronic conditions, including multiple sclerosis, cancer, diabetes and dementia. Chen's results suggest that drugs targeted toward deacetylating, or switching off, this NLRP3 inflammasome might help prevent or treat these conditions and possibly age-related degeneration in general.

"This acetylation can serve as a switch," Chen said. "So, when it is acetylated, this inflammasome is on. When it is deacetylated, the inflammasome is off."

[...] "I think this finding has very important implications in treating major human chronic diseases," Chen said. "It's also a timely question to ask, because in the past year, many promising Alzheimer's disease trials ended in failure. One possible explanation is that treatment starts too late, and it has gone to the point of no return. So, I think it's more urgent than ever to understand the reversibility of aging-related conditions and use that knowledge to aid a drug development for aging-related diseases."

Journal Reference:
Ming He, Hou-Hsien Chiang, Hanzhi Luo, Zhifang Zheng, Qi Qiao, Li Wang, Mingdian Tan, Rika Ohkubo, Wei-Chieh Mu, Shimin Zhao, Hao Wu, Danica Chen. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metabolism, 2020; DOI: 10.1016/j.cmet.2020.01.009


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  • (Score: 1, Interesting) by Anonymous Coward on Tuesday February 11 2020, @01:57PM (13 children)

    by Anonymous Coward on Tuesday February 11 2020, @01:57PM (#956828)

    In the current work, we found that vitamin C inhibited the NLRP3 inflammasome in vitro and in vivo. Scavenging of mitochondrial ROS by vitamin C was found to be one mechanism for the inhibition.
    [...]
    As an essential nutrient in human and other animal species, vitamin C plays multiple functions in antioxidative stress, anti-inflammation, improving visual health and even anti-cancer. Importantly, continuous uptake of vitamin C may not cause any side effect to our bodies. This is true in our experiment in that we did not observe any toxicity of vitamin C in vitro and in vivo. It would be interesting to investigate the anti-inflammasome potential of vitamin C by continuous lower-level uptake rather than several high dose injections in future studies

    https://www.deepdyve.com/lp/de-gruyter/vitamin-c-inhibits-the-activation-of-the-nlrp3-inflammasome-by-9FtxJwxWa0 [deepdyve.com]

    When are these people going to stop obsessing over implementation details and instead understand that cell activity/state is controlled by electron and ion levels?

    • (Score: 3, Interesting) by Anonymous Coward on Tuesday February 11 2020, @02:30PM (3 children)

      by Anonymous Coward on Tuesday February 11 2020, @02:30PM (#956836)

      I hate to say it, but have you considered that vitamin c can't be monetized...unless big pharma decides to expand into citrus growing?

      • (Score: 3, Informative) by Anonymous Coward on Tuesday February 11 2020, @02:45PM (2 children)

        by Anonymous Coward on Tuesday February 11 2020, @02:45PM (#956843)

        It is worse than that, the low fat, high sugar diet they recommend interferes with vitamin c absorption and transport (dehydroascorbate competes with glucose for glut1/3 transporters).

        So they are feeding you stuff to make you deficient in vitamin c then trying to come up with dozens of different expensive and dangerous treatments to fix the myriad of problems caused by the diet.

        • (Score: 2, Insightful) by Anonymous Coward on Tuesday February 11 2020, @06:57PM (1 child)

          by Anonymous Coward on Tuesday February 11 2020, @06:57PM (#956930)

          yes, and they always blame the immune system and these other processes for doing their goddamn jobs. it's not the immune systems fault that your BBB is porous from eating pig slop 24/7 so that viruses and chemicals are floating around in your brain, as one example. these hacks then prescribe immune suppressants. it's hard not to believe they are malicious.

          • (Score: 2, Touché) by Anonymous Coward on Tuesday February 11 2020, @08:03PM

            by Anonymous Coward on Tuesday February 11 2020, @08:03PM (#956946)

            They are trained to not use critical thinking or common sense. For example, I just heard a lady from WHO just say they had recently found that the virus could be spread within hospitals. No shit... It is like until there is undeniable proof they ignore even the most obvious thing.

    • (Score: 4, Informative) by ikanreed on Tuesday February 11 2020, @03:20PM (6 children)

      by ikanreed (3164) Subscriber Badge on Tuesday February 11 2020, @03:20PM (#956859) Journal
      • (Score: 0) by Anonymous Coward on Tuesday February 11 2020, @03:33PM (5 children)

        by Anonymous Coward on Tuesday February 11 2020, @03:33PM (#956865)

        Wtf is wrong with you? Did you even read any of the responses to your BS?

        Just stay the fuck away from me.

        • (Score: 2) by ikanreed on Tuesday February 11 2020, @04:32PM (4 children)

          by ikanreed (3164) Subscriber Badge on Tuesday February 11 2020, @04:32PM (#956884) Journal

          No, I didn't read "your" responses. I have no fucking idea who you are other than someone who promotes BS that just got a child killed.

          • (Score: 0) by Anonymous Coward on Tuesday February 11 2020, @06:20PM (3 children)

            by Anonymous Coward on Tuesday February 11 2020, @06:20PM (#956917)

            Seriously go away, keep your unscientific rage away from us.

            • (Score: 2) by ikanreed on Tuesday February 11 2020, @06:55PM (2 children)

              by ikanreed (3164) Subscriber Badge on Tuesday February 11 2020, @06:55PM (#956928) Journal

              I mean, you can call me angry if you want. After all, I very often am when it comes to ideologies that kill people pointlessly. But believing exactly as you believe very provably led a dumb woman to kill her child. Quite recently.

              • (Score: -1, Troll) by Anonymous Coward on Tuesday February 11 2020, @07:36PM (1 child)

                by Anonymous Coward on Tuesday February 11 2020, @07:36PM (#956940)

                You posted an anecdote from Facebook about one child dying after unknown dose wand treatment. Only a complete moron would draw the conclusions you do. Stay away from me.

                • (Score: 0) by Anonymous Coward on Wednesday February 12 2020, @12:42AM

                  by Anonymous Coward on Wednesday February 12 2020, @12:42AM (#957028)

                  "Stay away from me."

                  Somehow I doubt you have such problems.

    • (Score: 3, Interesting) by jmichaelhudsondotnet on Tuesday February 11 2020, @06:57PM (1 child)

      by jmichaelhudsondotnet (8122) on Tuesday February 11 2020, @06:57PM (#956929) Journal

      ikanreed is conflating two things that are dissimilar, this article does not recommend anyone treat the flu aggressively with vitamin C.

      Linux Pauling one of the most famous biochemists ever had noticed a correlation, like what you describe here.

      I am not sure what you mean by 'electron and ion levels', does that mean energy states? Numerical count?

      I do not think it is a coincidence that the one thing you needed on long boat voyages was....small daily doeses of vitamin C. OR EVERYONE WENT NUTS

      note: this does not mean you can cure everything with vitamin C, just that it is a core component of health, which this research supports

      • (Score: 1, Interesting) by Anonymous Coward on Tuesday February 11 2020, @07:40PM

        by Anonymous Coward on Tuesday February 11 2020, @07:40PM (#956942)

        The most important things in a cell are redox potential of various redox pairs (eg glutathione, NADH, NADPH), pH, and various ionic concentrations like Na+, Ca2+, etc.

        Morons like Ikanread know nothing about that so can't understand basic phyiology, cell bio, or biochem. All they do is memorize meaningless genetic correlations.

  • (Score: 2) by FatPhil on Tuesday February 11 2020, @02:47PM (3 children)

    by FatPhil (863) <pc-soylentNO@SPAMasdf.fi> on Tuesday February 11 2020, @02:47PM (#956844) Homepage
    Veritasium: How to Slow Aging (and even reverse it) https://www.youtube.com/watch?v=QRt7LjqJ45k
    --
    Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
    • (Score: 2) by jmichaelhudsondotnet on Tuesday February 11 2020, @06:51PM (2 children)

      by jmichaelhudsondotnet (8122) on Tuesday February 11 2020, @06:51PM (#956926) Journal

      Very long video, 1.4 gb to dl, care to summarize? What are we missing?

      btw my mod rights are still not reactivated and at this point I am going to need an explanation.

      Thanks

      • (Score: 2) by FatPhil on Wednesday February 12 2020, @09:56AM (1 child)

        by FatPhil (863) <pc-soylentNO@SPAMasdf.fi> on Wednesday February 12 2020, @09:56AM (#957150) Homepage
        luser@cubispaz:/usr/local/homes/luser$ youtube-dl -F https://www.youtube.com/watch?v=QRt7LjqJ45k
        [youtube] QRt7LjqJ45k: Downloading webpage
        [youtube] QRt7LjqJ45k: Downloading video info webpage
        [info] Available formats for QRt7LjqJ45k:
        format code extension resolution note
        249 webm audio only tiny 61k , opus @ 50k (48000Hz), 7.91MiB
        250 webm audio only tiny 79k , opus @ 70k (48000Hz), 10.04MiB
        140 m4a audio only tiny 131k , m4a_dash container, mp4a.40.2@128k (44100Hz), 19.59MiB
        251 webm audio only tiny 157k , opus @160k (48000Hz), 19.53MiB
        394 mp4 256x136 144p 82k , av01.0.00M.08, 24fps, video only, 9.40MiB
        160 mp4 256x136 144p 104k , avc1.4d400c, 24fps, video only, 7.80MiB
        278 webm 256x136 144p 106k , webm container, vp9, 24fps, video only, 11.99MiB
        395 mp4 426x224 240p 187k , av01.0.00M.08, 24fps, video only, 17.38MiB
        133 mp4 426x224 240p 227k , avc1.4d400d, 24fps, video only, 14.39MiB
        242 webm 426x224 240p 230k , vp9, 24fps, video only, 19.26MiB
        396 mp4 640x338 360p 359k , av01.0.01M.08, 24fps, video only, 30.94MiB
        243 webm 640x338 360p 492k , vp9, 24fps, video only, 35.20MiB
        134 mp4 640x338 360p 595k , avc1.4d401e, 24fps, video only, 38.98MiB
        397 mp4 854x450 480p 681k , av01.0.04M.08, 24fps, video only, 55.37MiB
        244 webm 854x450 480p 869k , vp9, 24fps, video only, 61.68MiB
        135 mp4 854x450 480p 1144k , avc1.4d401e, 24fps, video only, 77.77MiB
        398 mp4 1280x676 720p 1413k , av01.0.05M.08, 24fps, video only, 114.15MiB
        247 webm 1280x676 720p 1772k , vp9, 24fps, video only, 124.14MiB
        136 mp4 1280x676 720p 2199k , avc1.4d401f, 24fps, video only, 148.83MiB
        399 mp4 1920x1012 1080p 2513k , av01.0.08M.08, 24fps, video only, 200.77MiB
        248 webm 1920x1012 1080p 3762k , vp9, 24fps, video only, 220.34MiB
        137 mp4 1920x1012 1080p 4108k , avc1.640028, 24fps, video only, 269.32MiB
        271 webm 2560x1350 1440p 8426k , vp9, 24fps, video only, 591.77MiB
        313 webm 3840x2026 2160p 16820k , vp9, 24fps, video only, 1.47GiB
        18 mp4 640x338 360p 477k , avc1.42001E, mp4a.40.2@ 96k (44100Hz), 72.17MiB
        22 mp4 1280x676 720p 1112k , avc1.64001F, mp4a.40.2@192k (44100Hz) (best)

        You're able to download the one that's not 4K resolution, you know?

        Doctor, it hurts when I do *this*!
        Well, don't do that then.

        Your spam-mod case is still under discussion, there are arguments being made both in favour and against revocation of the mod ban.
        --
        Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
        • (Score: 2) by jmichaelhudsondotnet on Wednesday February 12 2020, @08:53PM

          by jmichaelhudsondotnet (8122) on Wednesday February 12 2020, @08:53PM (#957386) Journal

          Fair enough.

          I don't pollute my browser with youtube so i can only blindly download whatever url is on offer.

          But this is helpful, thanks Ill check it out on your rec.

  • (Score: 0, Interesting) by Anonymous Coward on Tuesday February 11 2020, @02:50PM (8 children)

    by Anonymous Coward on Tuesday February 11 2020, @02:50PM (#956846)

    It's obvious they don't want to "cure" disease, only find patches for "symptoms".

    It is well understood "inflammation" is a symptom of something else. In reality, inflammation is natural reaction to _something else entirely_. Like maybe deteriorating DNA, or toxins like heavy metals or preservative type chemicals built up in the body over decades. Where a weak immune system is failing.

    But you can't sell prevention, because if no one is sick they don't need your medicine. So, find something, anything and cure that, even if it's not the disease but sure looks bad.

    • (Score: 0) by Anonymous Coward on Tuesday February 11 2020, @04:55PM (3 children)

      by Anonymous Coward on Tuesday February 11 2020, @04:55PM (#956889)

      The mods here are off their meds...
      Some many mods on the site lately that are way out in left/right field now days.
      It's starting to drive me back to the Green Site....
      So much anger now days...
      Channel John Lennon and free yourself from the pain of hate.
      Peace Love Linux!

      • (Score: 4, Insightful) by RS3 on Tuesday February 11 2020, @06:04PM (2 children)

        by RS3 (6367) on Tuesday February 11 2020, @06:04PM (#956914)

        For the record, I have not down-modded you. I very rarely down-mod, even if I disagree- I respect and learn from others' thoughts.

        I've up-modded some AC posts here, probably up-modded you, but how could I know?

        I can't speak for others here, but being AC you: 1) detract from your potential reliability, and 2) there are many ACs here, which one are you?

        Join us and be part of an adult conversation.

        Or don't.

        • (Score: 0) by Anonymous Coward on Tuesday February 11 2020, @09:53PM (1 child)

          by Anonymous Coward on Tuesday February 11 2020, @09:53PM (#956986)

          Different AC here. (And I *always* post AC.)

          Every freaking site out there demands a login. Even the Green Site a while back finally banned anonymous posting. This is one of the few remaining places where you can still post your ideas and let them stand on their own. I am not about to wear a name tag simply to have permission to speak. Give the surveillance society a rest.

          • (Score: 4, Insightful) by RS3 on Tuesday February 11 2020, @10:24PM

            by RS3 (6367) on Tuesday February 11 2020, @10:24PM (#956996)

            I shouldn't even respond to your post, but once again, leap-o-logic. Now I'm supporting a surveillance society? Ridiculous statements like yours severely degrade what could be a great think-tank. And I suppose my responding to you also degrades the conversation.

            How would a login allow surveillance?

            How would being AC make it more difficult to surveil you?

            And, really, who would care to? Methinks you think too highly of yourself.

            BTW, AFAIK, "green site" allows you to post AC if you have a login and are otherwise logged in.

    • (Score: 4, Informative) by RS3 on Tuesday February 11 2020, @06:15PM (3 children)

      by RS3 (6367) on Tuesday February 11 2020, @06:15PM (#956916)

      Well, when doctors don't have a cure, or it might take too long, they do their best with what they have at their disposal and treat symptoms. If nothing else, treating symptoms often / usually gives patients relief & better quality of life.

      Doctors are pretty boxed in by FDA, lawyers/courts, patient expectations & demands, etc. And many diseases / conditions will "resolve" with treatment, you know, the body healing itself.

      Which brings me to inflation: as you wrote, inflation is a very frequent body's response to something being wrong. However, inflation in and of itself usually causes damage and many more problems, so reducing inflation often results in faster healing.

      However, inflation is often treated with steroids, and steroids usually suppress the immune system, so doctors are often forced to make difficult and compromising decisions.

      • (Score: 2, Informative) by Anonymous Coward on Tuesday February 11 2020, @06:47PM (1 child)

        by Anonymous Coward on Tuesday February 11 2020, @06:47PM (#956925)

        You mean inflammation. The mechanism via which inflammation can damage your tissue is via oxidation.

        Vitamin C is the terminal extracellular antioxidant (it regenerates all others). Glutathione is the terminal intracellular antioxidant.

        https://www.pnas.org/content/86/16/6377 [pnas.org]

        • (Score: 2) by RS3 on Tuesday February 11 2020, @09:22PM

          by RS3 (6367) on Tuesday February 11 2020, @09:22PM (#956970)

          Oh gosh, that's so embarrassing. Yes, I meant inflammation, not "inflation"!! That's what happens when I'm trying to write here while doing something attention-demanding.

          Thanks for all the info.

             

      • (Score: 2) by RS3 on Tuesday February 11 2020, @09:25PM

        by RS3 (6367) on Tuesday February 11 2020, @09:25PM (#956971)

        I meant to write "inflammation", not "inflation" - sorry everyone...

  • (Score: 2) by jmichaelhudsondotnet on Tuesday February 11 2020, @07:04PM

    by jmichaelhudsondotnet (8122) on Tuesday February 11 2020, @07:04PM (#956931) Journal

    "...a bulky collection of immune proteins called the NLRP3 inflammasome -- responsible for sensing potential threats to the body and launching an inflammation response -- can be essentially switched off by removing a small bit of molecular matter...."

    But they are also still on the holy grail quest of looking for a slave drug that enables humans to work themselves to the bone without pain while disabling their creative mind, so they never notice their enslavement.

    They can't give us all heroin, because that would be a reward, and you can't dole that out to mere proles! (or you can but it must be in the deadliest form to clear out riff raff, which is the real story of the so called opiod epidemic.

    https://archive.is/ZinJT [archive.is]
    thesesystemsarefailing.net

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