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posted by martyb on Sunday May 17 2020, @04:17PM   Printer-friendly [Skip to comment(s)]
from the getting-closer dept.

From the latest blog post of Derek Lowe :

One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new paper is a good example. A team from the La Jolla Institute for Immunology, UNC, UCSD, and Mt. Sinai (NY) reports details about the T cells of people who have recovered from the virus.

[...] So overall, this paper makes the prospects for a vaccine look good: there is indeed a robust response by the adaptive immune system, to several coronavirus proteins. And vaccine developers will want to think about adding in some of the other antigens mentioned in this paper, in addition to the Spike antigens that have been the focus thus far. It seems fair to say, though, that the first wave of vaccines will likely be Spike-o-centric, and later vaccines might have these other antigens included in the mix. But it also seems that Spike-protein-targeted vaccines should be pretty effective, so that’s good. The other good news is that this team looked for the signs of an antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring). And it also looks like the prospects for (reasonably) lasting immunity after infection (or after vaccination) are good. This, from what I can see, is just the sort of response that you’d want to see for that to be the case. Clinical data will be the real decider on that, but there’s no reason so far to think that a person won’t have such immunity if they fit this profile.

Onward from here, then – there will be more studies like this coming, but this is a good, solid look into the human immunology of this outbreak. And so far, so good.

Be sure to read the article if you’ve been wondering what your thymus has done for you lately.

Journal Reference
Alba Grifoni, Daniela Weiskopf. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals, Cell (DOI: 10.1016/j.cell.2020.05.015)


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  • (Score: 5, Informative) by jelizondo on Sunday May 17 2020, @04:36PM (4 children)

    by jelizondo (653) Subscriber Badge on Sunday May 17 2020, @04:36PM (#995401) Journal

    First, I’ll say that we don’t know much at this time about the COVID-19 virus.

    From what I read, people that had the infection could be reinfected, which would speak against a vaccine or “herd immunity” much touted by different governments and/or scientists.

    See:

    Risk of reactivation or reinfection of novel coronavirus (COVID-19) [nih.gov]

    This issue has been brought to the public attention as on April 13, South Korea reported that 116 recovered cases of COVID-19 has been found positive again

    Recovered patients who tested positive for COVID-19 likely not reinfected [livescience.com]

    Reports of patients testing positive twice aren't limited to South Korea; they have also poured in from other countries, including China and Japan. But the general consensus in the scientific community — with all the information available to date on the new coronavirus — is that people aren't being reinfected, but rather falsely testing positive, Reiss said.

    So maybe, maybe not. We need more research and more reliable test to make sure.

    • (Score: 4, Insightful) by PocketSizeSUn on Sunday May 17 2020, @04:56PM

      by PocketSizeSUn (5340) on Sunday May 17 2020, @04:56PM (#995405)

      All of these cases can easily be attributed to failed testing (people being cleared that were simply below the PCR test sensitivity levels, or other PCR test accuracy fault), use of antivirals (which would not confer immunity).

      But yes. it is very important to keep ramping up the fear .. must ... must ... omb ... omb!

    • (Score: 2) by JoeMerchant on Sunday May 17 2020, @07:09PM

      by JoeMerchant (3937) on Sunday May 17 2020, @07:09PM (#995433)

      maybe, maybe not

      Always the case until more data is available.

      About those things you've "heard" so far... bear in mind the crappy performance of the early (and even current) tests, the slip-shod interpretation of the results, the political lensing of all the results distorting to obtain desired behaviors in the population rather than spread anything related to the truth.

      U.S. strategy (once the U.S. had a strategy beyond wishing it was all a false alarm) seems to have been pretty consistent: flatten the curve. This was the early message attributed to Obama, and all policy decisions to-date seem to have been somewhat successfully achieving that result. Whether by luck, or some prior information about COVID-19 along the lines of TFA, flattening the curve would seem to be a reasonable approach for minimal impact to the beloved economy / socio-economic hierarchy. Just make sure your at risk friends and loved ones protect themselves, otherwise they're going to be personally contributing to the post-COVID-19 reduced elder and healthcare burden dividend.

      --
      My karma ran over your dogma.
    • (Score: 2) by driverless on Monday May 18 2020, @12:29AM

      by driverless (4770) on Monday May 18 2020, @12:29AM (#995534)

      Yup. There's lots of studies strongly indicating you can get reinfected, meaning you don't build up immunity, or that it's only temporary. Picking out this one study that says something you'd really like to hear doesn't invalidate all of the others. That, combined with the fact that no-one has ever managed to create an effective vaccine for a coronavirus, means I'm betting on ongoing precautions rather than a silver bullet vaccine for the future.

    • (Score: 2) by Reziac on Monday May 18 2020, @04:38AM

      by Reziac (2489) on Monday May 18 2020, @04:38AM (#995609) Homepage

      Just as a data point: Dogs that have recovered from parvovirus typically harbor live virus for a year or more afterward (and will shed infective virus in feces). In rare cases they have a relapse (usually less serious). Anyway, not an unknown scenario.

  • (Score: 3, Informative) by PocketSizeSUn on Sunday May 17 2020, @04:51PM (36 children)

    by PocketSizeSUn (5340) on Sunday May 17 2020, @04:51PM (#995402)

    Average immunity for SARS is 2 years:
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851497/ [nih.gov]
    There is absolutely no indication or expectation that SARS v1 differs from SARS v2 significantly enough to suggest that there is some radically different immune response.

    NOTE: Using one of the antivirals (Remdesivir et. al) to fight off SARS would absolutely not be expected to confer immunity.

    • (Score: 3, Informative) by Azuma Hazuki on Sunday May 17 2020, @04:55PM (33 children)

      by Azuma Hazuki (5086) on Sunday May 17 2020, @04:55PM (#995404) Journal

      Assuming this one acts like SARS, it would make sense to get a combined nCov-2019/influenza vaccine every year, IMO.

      --
      I am "that girl" your mother warned you about...
      • (Score: 2, Disagree) by PocketSizeSUn on Sunday May 17 2020, @05:03PM (31 children)

        by PocketSizeSUn (5340) on Sunday May 17 2020, @05:03PM (#995406)

        Assuming this one is like SARS-v1 (yes) an effective vaccine is quite unlikely to arrive soon. The SARS-v1 vaccine was scrapped because the outcomes were worse that the disease ... and SARS-v1 was 10x more deadly that SARS-v2.

        If the current IFR rates hold steady an vaccine will be nearly as pointless as the yearly flu vaccine.

        FYI the yearly flu vaccine is only lines up with the flu 1/3 of the time? So only 1 year in 3 is the flu vaccine the one for the flu that is going around. 2 out of 3 years you get a vaccine for the wrong flu.

        Finally the flu vaccine is only confers immunity for an average of 6 months.

        So bottom line. No it doesn't make sense.

        • (Score: 4, Insightful) by Azuma Hazuki on Sunday May 17 2020, @05:11PM (19 children)

          by Azuma Hazuki (5086) on Sunday May 17 2020, @05:11PM (#995410) Journal

          What do you suggest then? My main motivation for mixing the two is the flu shots are well-covered by Medicare (so the elderly and very sick get them free). If the government thinks flu is important enough to vaccinate against like that, then nCov-2019 sure as hell ought to be. More so, if anything.

          --
          I am "that girl" your mother warned you about...
          • (Score: 4, Interesting) by PocketSizeSUn on Sunday May 17 2020, @05:38PM

            by PocketSizeSUn (5340) on Sunday May 17 2020, @05:38PM (#995413)

            You will need to get the a SARS *series* of vaccines as profitable as the flu vaccine.

                  https://www.npr.org/sections/health-shots/2019/12/20/784608400/do-you-really-need-a-flu-shot-heres-how-to-decide [npr.org]

                  https://www.wired.com/story/flu-vaccine-big-pharma/ [wired.com]

                  https://www.drugwatch.com/news/2018/02/19/us-flu-season-reaches-peak-vaccine-profits-climb/ [drugwatch.com]

            Since China is doing the vaccine and GoF research ... we could just wait for a Made-in-China solution to a Made-in-China problem?
            Or maybe a little oversight on China's rapid increase in GoF and vaccine research? China is now building out BSL4 labs as fast as they built a containment hospital in Wuhan.

            It is also worth noting that China has been doing GoF + SARS development in lower classifcation labs as well as in WIV BSL4 lab. They plan to build 5 to 7 labs

            https://www.scientificamerican.com/article/china-to-permit-lab-poised-to-study-worlds-most-dangerous-pathogens/ [scientificamerican.com]

            The move is part of a plan to build between five and seven biosafety level-4 (BSL-4) labs across the Chinese mainland by 2025

            governments will assume that such excess capacity is for the potential development of bioweapons

            “These facilities are inherently dual use,”

            So ask yourself this. Did China react the way they did in Wuhan because they thought the had a SARS outbreak ... or because they thought they had a containment problem of something much worse leak out of WIV?

          • (Score: 2) by JoeMerchant on Sunday May 17 2020, @07:11PM

            by JoeMerchant (3937) on Sunday May 17 2020, @07:11PM (#995435)

            the flu shots are well-covered by Medicare (so the elderly and very sick get them free). If the government thinks flu is important enough

            Ever the optimist, assuming that the government's primary motivation is protecting the well being of their most costly citizens.

            --
            My karma ran over your dogma.
          • (Score: 2) by Bot on Monday May 18 2020, @01:17AM (1 child)

            by Bot (3902) on Monday May 18 2020, @01:17AM (#995556) Journal

            Are you aware plasma from survivors does cure the covid? even the evil gates is eyeing that therapy. Using plasma is a delicate matter, sure, but given the way vaccines are manufactured and prescribed, getting plasma should not scare you much.

            --
            Account abandoned.
            • (Score: 2) by Azuma Hazuki on Monday May 18 2020, @01:34PM

              by Azuma Hazuki (5086) on Monday May 18 2020, @01:34PM (#995748) Journal

              Yes, I am. At some point, I plan to get tested, and if it's positive (I've had no symptoms at all, so am either uninfected or asymptomatic and recovered) I plan to donate plasma when possible.

              --
              I am "that girl" your mother warned you about...
          • (Score: 2) by Reziac on Monday May 18 2020, @04:48AM (14 children)

            by Reziac (2489) on Monday May 18 2020, @04:48AM (#995613) Homepage

            I agree, and take it a step further -- do like was common in the 1980s, and in some places even today -- vaccine is cheap or even free to everyone. Tho it might not be a good idea to combine CV and influenza vaccines; a few weeks apart would be better for maximum immunity and fewest fails/bad reactions. At least until we determine if there's any interaction. (Sometimes one vaccine can interfere with another.)

            Up here in Redneck Land, some counties have an RV that tours every wide spot in the road giving out vaccine for every disease known to man... having found that free vaccine is a lot cheaper than treating the illness. Last time I encountered the vaccine tourbus, I went home immune to everything but death and looking like a pincushion. :D

            • (Score: 2) by Azuma Hazuki on Monday May 18 2020, @01:35PM (13 children)

              by Azuma Hazuki (5086) on Monday May 18 2020, @01:35PM (#995749) Journal

              Sounds like *socialism* ta me, boy..whah duh yew hayt uh-merrika?

              --
              I am "that girl" your mother warned you about...
              • (Score: 2, Disagree) by Reziac on Monday May 18 2020, @02:03PM (12 children)

                by Reziac (2489) on Monday May 18 2020, @02:03PM (#995766) Homepage

                Socialism is when you don't have a choice, you participate or else. Socialism only 'works' when there's a man with a gun to enforce participation.

                No one forced us to line up for flu vaccine; we merely observed that flu was worse than an hour in line on a subzero night. No one forced county health to juggle numbers and decide vaccine was cheaper than disease. In both cases it was purely enlightened self-interest, for which we were willing to spend a tiny bit of those tax dollars we'd already paid.

                • (Score: 2, Disagree) by Azuma Hazuki on Tuesday May 19 2020, @12:49AM (11 children)

                  by Azuma Hazuki (5086) on Tuesday May 19 2020, @12:49AM (#996105) Journal

                  "Or else" what, pray tell? Because in a crony-capitalist milieu like the modern US, the "or else" is equally dire.

                  --
                  I am "that girl" your mother warned you about...
                  • (Score: 2) by Reziac on Tuesday May 19 2020, @01:05AM (10 children)

                    by Reziac (2489) on Tuesday May 19 2020, @01:05AM (#996111) Homepage

                    Or else what? The best answer came from Lenin or Stalin or Mao, tho there have been plenty of also-rans (eg. Castro and Chavez).

                    • (Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:14AM (9 children)

                      by Azuma Hazuki (5086) on Tuesday May 19 2020, @01:14AM (#996115) Journal

                      Same shit happens here in the US, just slower: you die. I think I'd rather be shot than starve. You're dishonest as Hell, you know that?

                      --
                      I am "that girl" your mother warned you about...
                      • (Score: 2) by Reziac on Tuesday May 19 2020, @02:49AM (8 children)

                        by Reziac (2489) on Tuesday May 19 2020, @02:49AM (#996144) Homepage

                        And you're pleasant company, as always.

                        • (Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:26PM (7 children)

                          by Azuma Hazuki (5086) on Tuesday May 19 2020, @01:26PM (#996325) Journal

                          Cry harder. I may be unpleasant to the deserving, but I'm also correct. If you don't like getting snarked at, don't say stupid shit.

                          --
                          I am "that girl" your mother warned you about...
                          • (Score: 2, Insightful) by Reziac on Tuesday May 19 2020, @02:50PM (6 children)

                            by Reziac (2489) on Tuesday May 19 2020, @02:50PM (#996362) Homepage

                            No, you're unpleasant because you're wrong and you don't have a good argument, but you do have a fine stable of insults. We all use the skills we're able...

                            ;)

                            • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @12:24AM (5 children)

                              by Azuma Hazuki (5086) on Wednesday May 20 2020, @12:24AM (#996631) Journal

                              So this is what you descend to? No, I'm correct, and if I weren't you wouldn't be getting so upset about it. The nastiness is just the well-deserved icing on the cake. Fuck off, keep fucking off until you've circumnavigated the globe and fucked off right back to where you started, then fuck off one more time.

                              --
                              I am "that girl" your mother warned you about...
                              • (Score: 2, Funny) by Reziac on Wednesday May 20 2020, @12:39AM (4 children)

                                by Reziac (2489) on Wednesday May 20 2020, @12:39AM (#996636) Homepage

                                I'm not upset. I love you too. :D

                                • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @05:20AM (3 children)

                                  by Azuma Hazuki (5086) on Wednesday May 20 2020, @05:20AM (#996757) Journal

                                  Denial. Ain't just a big wet in Egypt.

                                  --
                                  I am "that girl" your mother warned you about...
                                  • (Score: 2) by Reziac on Wednesday May 20 2020, @06:38AM (2 children)

                                    by Reziac (2489) on Wednesday May 20 2020, @06:38AM (#996772) Homepage

                                    You can get Depends for that...

                                    • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @01:10PM (1 child)

                                      by Azuma Hazuki (5086) on Wednesday May 20 2020, @01:10PM (#996861) Journal

                                      If it weren't bothering you, *you wouldn't keep replying.* You fat middle-aged manchildren are all so goddamn *predictable.*

                                      --
                                      I am "that girl" your mother warned you about...
                                      • (Score: 2) by Reziac on Wednesday May 20 2020, @02:45PM

                                        by Reziac (2489) on Wednesday May 20 2020, @02:45PM (#996905) Homepage

                                        No, I do it to keep YOU replying. Because you're so predictable. :D

        • (Score: 2) by NickM on Sunday May 17 2020, @09:13PM (9 children)

          by NickM (2867) Subscriber Badge on Sunday May 17 2020, @09:13PM (#995463) Journal

          The other good news is that this team looked for the signs of an antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring).

          As far as I know it was scrapped because the disease died out. According to https://www.clinicaltrials.gov/ct2/show/NCT00533741 [clinicaltrials.gov] 0 person were enrolled into it's trial. How can you claim that the vaccine outcome was worse than the disease when it was not even tested ? If you have some credible references contradicting what I have posted, please share them. If you don't, please refrain from spreading unsubstantiated disinformation.

           

          --
          I a master of typographic, grammatical and miscellaneous errors !
          • (Score: 5, Informative) by PocketSizeSUn on Sunday May 17 2020, @11:35PM (8 children)

            by PocketSizeSUn (5340) on Sunday May 17 2020, @11:35PM (#995506)

            https://theconversation.com/the-mysterious-disappearance-of-the-first-sars-virus-and-why-we-need-a-vaccine-for-the-current-one-but-didnt-for-the-other-137583 [theconversation.com]

            What about a SARS vaccine? Vaccine studies for SARS-CoV-1 were started and tested in animal models. An inactivated whole virus was used in ferrets, nonhuman primates and mice. All of the vaccines resulted in protective immunity, but there were complications; the vaccines resulted in an immune disease in animals.

            Hence clincial study withdrawn.

            As to the obvious follow-on question of why did research in to SARS-CoV-1 vaccines stop ... it didn't. That's why there a hundreds of samples of bat virii and GoF testing being done.

            • (Score: 2) by NickM on Sunday May 17 2020, @11:41PM

              by NickM (2867) Subscriber Badge on Sunday May 17 2020, @11:41PM (#995507) Journal
              Thank you for the link.
              --
              I a master of typographic, grammatical and miscellaneous errors !
            • (Score: 2) by NickM on Sunday May 17 2020, @11:46PM (1 child)

              by NickM (2867) Subscriber Badge on Sunday May 17 2020, @11:46PM (#995511) Journal
              But why did you excluded the following paragraph from your quote ?

              No human studies were done, nor were the vaccine studies taken further because the virus disappeared. Many factors were involved in the end of SARS-CoV-1, perhaps including summer weather, and certainly strict quarantine of all those who had contact with infected individuals, but we don’t really know why the epidemic ended. Viruses are like that, unpredictable!

              --
              I a master of typographic, grammatical and miscellaneous errors !
              • (Score: 3, Informative) by PocketSizeSUn on Monday May 18 2020, @12:05AM

                by PocketSizeSUn (5340) on Monday May 18 2020, @12:05AM (#995521)

                Because the author's assertion is mostly inaccurate.

                There were human trials with other attempts at SARS vaccines. The SARS family virii continue to be studied and attempts at vaccines continue to be developed.

                The *pace* of development may have changed but is rather typical in these cases ..

            • (Score: 4, Informative) by PocketSizeSUn on Sunday May 17 2020, @11:52PM (4 children)

              by PocketSizeSUn (5340) on Sunday May 17 2020, @11:52PM (#995514)

              And one with human subjects in China:
              https://www.intmedpress.com/serveFile.cfm?sUID=bba35bb3-9126-4c66-ae0f-4e96b8291dea [intmedpress.com]

              This one protected 83.33% of the study subjects for > 210 days. It used two vaccinations and ~8 weeks to achieve seropositive, had complications (not immediately life threatening) however some test subjects ended up with impaired liver functions.

              More research on the influences of SARS-CoV on liver functions in animal experiments are need to address the potential liver damage of SARS virus vaccine candidates.

              It did not progress to a clinical trial.

              • (Score: 0) by Anonymous Coward on Sunday May 17 2020, @11:58PM (2 children)

                by Anonymous Coward on Sunday May 17 2020, @11:58PM (#995516)
                Did you read the abstract of your link ?

                Conclusion: The inactivated vaccine was safe and well tolerated and can elicit SARS-CoV-specific neutralizing antibodies.

                • (Score: 3, Informative) by PocketSizeSUn on Monday May 18 2020, @12:28AM (1 child)

                  by PocketSizeSUn (5340) on Monday May 18 2020, @12:28AM (#995533)

                  Yes .. I actually read the whole study which you obviously did not.

                  The vaccine achieved seropositive results (that's good) but also cause liver disease (that's bad).
                  The level of seropositive achieved is believed to be 'enough' but was below the level of seropositive of people who had SARS and survived (this is not atypical of a vaccine).
                  So this vaccine may work but you have to get it in stages to get enough immunity to maintain any realistic possibility of protection from SARS.

                  Also the trial size 36 healthy adults. That means that even 1 case of liver disease => 3% chance, 2 => 6% chance.
                  Any sane person would RTFA (run-the-*-away) from this one.

                  • (Score: 2) by NickM on Monday May 18 2020, @01:00AM

                    by NickM (2867) Subscriber Badge on Monday May 18 2020, @01:00AM (#995548) Journal
                    A transient increase in serum ALT is not that relevant in this study, again you selectivly choose not to state that it also occured in the placebo control group (1/12)...
                    --
                    I a master of typographic, grammatical and miscellaneous errors !
              • (Score: 2) by NickM on Monday May 18 2020, @12:06AM

                by NickM (2867) Subscriber Badge on Monday May 18 2020, @12:06AM (#995522) Journal

                Although a group has reported that they observed severe liver inflammation when a recom- binant vaccine, created by genetically modifying a pox virus to produce SARS-CoV spike (S) protein, was tested in ferrets [14], our previously performed pathological study on monkeys [15] and another study [16] did not find any evidence of liver damage. More research on the influences of SARS-CoV on liver functions in animal experiments are needed to address the potential liver damage of SARS virus vaccine candidates.

                --
                I a master of typographic, grammatical and miscellaneous errors !
        • (Score: 2) by Reziac on Monday May 18 2020, @05:01AM

          by Reziac (2489) on Monday May 18 2020, @05:01AM (#995616) Homepage

          Back when flu vaccine was the new kid on the block, after I'd had 3 or 4 different vaccines, I noticed that I didn't get the flu anymore, not even if this year's vaccine proved to be the wrong one. So appears there's some cross-coverage, and enough immune memory to be useful even if the current vaccine is a near-miss. And if there's only strong immunity long enough to cover flu season -- well, the rest of the year you don't need it anyway. Regardless, I find it prudent, especially as an old fart, to get the shot every year. If CV19 vaccine becomes part of the annual pincushioning, well, it's better than being sick, especially as one approaches the high-fatality age bracket.

          And when/if a vaccine is developed... well, it's better to not load up the healthcare system with preventable disease, even if the vaccine coverage is a bit iffy.

      • (Score: 0, Disagree) by Anonymous Coward on Monday May 18 2020, @01:05AM

        by Anonymous Coward on Monday May 18 2020, @01:05AM (#995551)

        Read up on it: https://en.wikipedia.org/wiki/Antibody-dependent_enhancement [wikipedia.org]
        And specifically this part: https://en.wikipedia.org/wiki/Antibody-dependent_enhancement#In_coronavirus_infection [wikipedia.org]

        Biology is NOT a school testsheet where you check the right boxes and receive an A. Here in the real world, an overachiever can get a nice grave for their effort. Like they say, "if you drive like hell, you're bound to get there".

    • (Score: 4, Interesting) by https on Monday May 18 2020, @01:43AM (1 child)

      by https (5248) on Monday May 18 2020, @01:43AM (#995565)

      You suggest,

      There is absolutely no indication or expectation that SARS v1 differs from SARS v2 significantly enough to suggest that there is some radically different immune response

      I think the wildly different asymptomatic phases, the eradicated circulatory systems, the demolished kidneys, the second-order Kawasaki syndrome, and so on and so on... all indicate a radically different immune response just might be possible.

      --
      Offended and laughing about it.
      • (Score: 2) by PocketSizeSUn on Monday May 18 2020, @03:51AM

        by PocketSizeSUn (5340) on Monday May 18 2020, @03:51AM (#995602)

        The list of symptoms is a non-sequitur to the question of immune response. Since the mechanism of infection is the same spike protein there is good reason to expect that once you are seropositive for CoV-2 you are immune for some time. The time period is very likely to be the similar to that of CoV-1.

        Agreed that CoV-1 did not appear to have a long asymptomatic period before viral shedding so that's both new and surprising.

  • (Score: 4, Interesting) by Snotnose on Sunday May 17 2020, @05:12PM (2 children)

    by Snotnose (1623) on Sunday May 17 2020, @05:12PM (#995411)

    One of the comments mentions Cells at Work! (https://en.wikipedia.org/wiki/Cells_at_Work!). I watched the first episode on YouTube, it was, um, interesting.

    --
    The skulls of my enemies are much more enviromentally friendly than plastic cups. just sayin.
    • (Score: 3, Interesting) by hendrikboom on Sunday May 17 2020, @06:48PM

      by hendrikboom (1125) on Sunday May 17 2020, @06:48PM (#995429) Homepage Journal

      Cells at work is indeed interesting. My wife was a doctor and an immunologist, well versed in cell biology, so it was an especial treat for her. She would explain technical details to me.

    • (Score: 0) by Anonymous Coward on Monday May 18 2020, @02:48PM

      by Anonymous Coward on Monday May 18 2020, @02:48PM (#995808)

      There's a UK doctor who has been watching and commenting on the series. Lately he's also been vlogging about the COVID experience at hospital:
      https://www.youtube.com/channel/UCMtZt5KQmhCLXiQVRhIgzTg [youtube.com]

  • (Score: 1, Interesting) by Anonymous Coward on Sunday May 17 2020, @05:58PM (4 children)

    by Anonymous Coward on Sunday May 17 2020, @05:58PM (#995421)

    The common cold is not one where you get a permanent immunity, but if it hasn't been too long since the last one, the next one is mild and refreshes your immune system's memory. Most of the population has some sort of immunity and the virus is continually circulating in the community.

    A common cold is not bad because the first time you get it is when you are very young and your immune system stay's wise to it. If you get a common cold for the first time when you are old, I wonder if is is likely to be serious.

    If CV-19 is similar but new with few wise immune systems, would we expect a similar detente, but not eradication?

    If this is the case, then maybe the vaccine needs not to provide complete immunity with no virus circulating. It just needs to get us to where we were after the common cold at a young age.

    • (Score: 2) by el_oscuro on Sunday May 17 2020, @06:30PM (2 children)

      by el_oscuro (1711) on Sunday May 17 2020, @06:30PM (#995425)

      Last year, I got a flu shot late in the season - and then a month later I contracted the flu. I went to the doctor and tested positive for the flu. This was pretty surprising given I had had the flu shot.

      But the symptoms cleared out in a few days instead of lasting the typical week, so I guess the flu shot helped.

      --
      SoylentNews is Bacon! [nueskes.com]
      • (Score: 3, Funny) by Anonymous Coward on Sunday May 17 2020, @07:40PM (1 child)

        by Anonymous Coward on Sunday May 17 2020, @07:40PM (#995444)

        Flu shot is not 100% effective at preventing the flu, just as MMR vaccine is not 100% effective at giving your children autism.

        • (Score: 0) by Anonymous Coward on Sunday May 17 2020, @08:26PM

          by Anonymous Coward on Sunday May 17 2020, @08:26PM (#995450)

          Nor will any Covid-19 vaccine, when and if it ever will come out, be 100% effective at preventing getting ill with Covid-19.

          Does this scare some of you cowering in fear at home? Get over it, by then the presidential election will have passed and the MSM will tell you to suck it up.

    • (Score: 5, Informative) by hendrikboom on Sunday May 17 2020, @06:54PM

      by hendrikboom (1125) on Sunday May 17 2020, @06:54PM (#995430) Homepage Journal

      There are maybe a hundred or so different organisms that cause the common cold, both viral and bacterial. Only few are coronaviruses. Acquiring immunity to one doesn't help much against the others.

  • (Score: 1, Troll) by Username on Monday May 18 2020, @12:55AM (3 children)

    by Username (4557) on Monday May 18 2020, @12:55AM (#995546)

    SARS-CoV-2 COVID-19 Corona Wuhan China Virus. Can we please just pick one and go with it.

    • (Score: 2, Offtopic) by Bot on Monday May 18 2020, @01:11AM (1 child)

      by Bot (3902) on Monday May 18 2020, @01:11AM (#995552) Journal

      Kung flu 1.3 : It conveys everything, nature, origin, version, and it has that martial undertone.

      --
      Account abandoned.
      • (Score: 1, Funny) by Anonymous Coward on Monday May 18 2020, @08:27PM

        by Anonymous Coward on Monday May 18 2020, @08:27PM (#995997)

        Kung flu 1.3 : It conveys everything, nature, origin, version, and it has that martial undertone.

        Everybody was Kung flu fighting,
        it spread as fast as lightning.

    • (Score: 4, Informative) by Anonymous Coward on Monday May 18 2020, @07:15AM

      by Anonymous Coward on Monday May 18 2020, @07:15AM (#995635)
      Names have been chosen: SARS-CoV-2 is the name of the virus, which causes the disease named COVID-19, just like HIV is the virus, and AIDS the name of the disease it causes. That's the official terminology. It's just that some people who seem to have an agenda involving sowing more discrimination and division insist on using other, much more loaded terms like the other ones you've mentioned.
  • (Score: 0) by Anonymous Coward on Monday May 18 2020, @08:30PM

    by Anonymous Coward on Monday May 18 2020, @08:30PM (#995998)

    my hope is that we "domesticate" sars2: going in and out and in and out of humans long enough (attenuation?) and avoiding going back to original host.
    this way it will probably get less lethal and just join the club of other corona viruses that infect humans (another type of common cold)...

    one wonders if there once were really really lethal viruses in the human past but they made quick work of their hosts: that they made them too ill to move around and live long enough to infect others ... thus dying out ... and forgotten.

    obviously there are still viruses that infect humans around. for influence, for which the cold winter months are high season, jumps over the equator and then back or/and it just lies dormant in some bunker with a sign "do not open until september!" ... or dengue fever ...zika? the pool remains ... it seems.
    unless there is a mechanism we don't know about, that is akind to a geyser, a literal hole in the ground from which virus are emitted by the planet?
    if this is not the case then all viruses that infect humans are just going round and around and around thus kindda making the likelihood of the sars2 disappearing unrealistic. but one can hope! ^_^

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