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posted by requerdanos on Friday January 08 2021, @06:00AM   Printer-friendly

Main bioactive compound of ginger root may protect against autoimmune disease progression:

Naturopathic medicine, or herbal medicine, is all the rage, especially among young people. But how much of this is supported by science?

Ginger is known to have anti-inflammatory and anti-oxidative effects, making it a popular herbal supplement to treat inflammatory diseases.

And according to a Michigan Medicine led study published in JCI Insight, the main bioactive compound of ginger root, 6-gingerol, is therapeutic in countering the mechanism that fuels certain autoimmune diseases in mice. Researchers specifically looked at lupus, a disease which attacks the body's own immune system, and its often associated condition antiphospholipid syndrome, which causes blood clots, since both cause widespread inflammation and damage organs overtime.

[...] The study question was, "will the anti-inflammatory properties of ginger extend to neutrophils, and specifically, can this natural medicine stop neutrophils from making [Neutrophil Extracellular Traps, or] NETs that contribute to disease progression?"

"This pre-clinical study in mice offers a surprising and exciting, 'yes'," [lead study author Dr. Ramadan] Ali says.

Journal Reference:
Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, et al. Anti-neutrophil properties of natural gingerols in models of lupus [open], JCI Insight (DOI: 10.1172/jci.insight.138385)


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  • (Score: 1, Insightful) by Anonymous Coward on Friday January 08 2021, @08:29AM (4 children)

    by Anonymous Coward on Friday January 08 2021, @08:29AM (#1096925)

    Now I can reclassify ginger snap cookies from junk food to health food.

    • (Score: 0) by Anonymous Coward on Friday January 08 2021, @08:54AM (1 child)

      by Anonymous Coward on Friday January 08 2021, @08:54AM (#1096928)

      Just replace the sugar with Splenda.

      • (Score: 1, Informative) by Anonymous Coward on Friday January 08 2021, @12:10PM

        by Anonymous Coward on Friday January 08 2021, @12:10PM (#1096955)

        I scoff at your quaint Splenda idea...by scoffing these. [borderbiscuits.co.uk]

        Apart from the taste issue as, to me, both Sucralose and Stevia taste 'nasty' (but not nearly as nasty as Aspartame) there are concerns about the use of Sucralose in baked produce, the usual 'reaction with other compounds at high temperatures' route to producing carcinogens...so I think I'll keep my limited exposure to Sucralose to those rare 'oh bugger, there's no cold drinks in the fridge other than this diet crap...needs must' occasions.

    • (Score: 2) by looorg on Friday January 08 2021, @09:24AM (1 child)

      by looorg (578) on Friday January 08 2021, @09:24AM (#1096935)

      So does the ginger snap cookies contain actual ginger and not just some chemical combination that produces ginger flavor? If not you might as well just drink ginger ale, liquid healing!

      • (Score: 0) by Anonymous Coward on Friday January 08 2021, @01:12PM

        by Anonymous Coward on Friday January 08 2021, @01:12PM (#1096967)

        I don't know about your stateside cookies, but the ginger biscuits this side of the pond all contain ginger, mostly powdered dried root, but sometimes stem ginger, depending on their degree of 'fancy'.

        But yes, ginger ale, now there is an idea...

        It's just a pity that here in the UK they've adulterated most of the readily available brands with artificial sweeteners...thank you, Mr fscking sugar tax [www.gov.uk].

        If you'll forgive the slight asides here, there are a couple of well known brands of bitter soft drinks I'll no longer buy because they needlessly replaced what little sugar they did contain with stevia, and royally fucked up the taste...yes, I can detect the taste of the stuff in both their bitter orange and lemon drinks, in fact, I only found out about the change the hard way when one day I took a swig from a can of the lemon drink and spat it back out with a loud 'what the fuck?' as it tasted so foul. I once took part in blind tests when the marketing wonks wanted feedback on another soft drink's new formula to avoid the sugar tax, took a sip of sample Y, the looks on their faces when I told them that the stevia they'd added ruined the taste...how did I know it was stevia? (steviol glycosides is what they're calling them on the ingredient lists...stevia's a trademark.) long discussion about how 'sweetness' isn't the whole story with the stuff, there are it's 'undertones' as well, and the horrible nasty cloying aftertaste which lasts for something like 20 minutes...they made notes, nodded politely, but never learn...insanity, it's just fucking box-ticking virtue-signalling insanity.

        Anyhoo, yes, ginger ale, time to make my own again..assuming Brexit hasn't killed off root ginger imports as well, that is.

  • (Score: 2) by Azuma Hazuki on Friday January 08 2021, @01:25PM (3 children)

    by Azuma Hazuki (5086) on Friday January 08 2021, @01:25PM (#1096973) Journal

    I cook with lots of ginger, grated fresh into the food, and will make tea by pouring boiling water over it. With a little stevia and a splash of lemon juice you get something that's nice on its own and also works with tea. I wonder if a lifetime of ginger use will help me avoid the diseases of old age when the time comes?

    --
    I am "that girl" your mother warned you about...
    • (Score: 2) by HiThere on Friday January 08 2021, @03:20PM (2 children)

      by HiThere (866) Subscriber Badge on Friday January 08 2021, @03:20PM (#1096998) Journal

      More likely your body will have pre-adapted to consider a level of ginger based chemicals normal...and respond poorly if you withdraw.

      After all, those net cells are normally desirable. They're only a problem when the immune system is "fooled" by an infection. Normally they're used to trap invasive particles safely.

      --
      Javascript is what you use to allow unknown third parties to run software you have no idea about on your computer.
      • (Score: 0) by Anonymous Coward on Friday January 08 2021, @04:26PM (1 child)

        by Anonymous Coward on Friday January 08 2021, @04:26PM (#1097020)

        Any references on "ginger tolerance buildup or related?

        • (Score: 3, Informative) by NickM on Friday January 08 2021, @06:01PM

          by NickM (2867) on Friday January 08 2021, @06:01PM (#1097054) Journal

          The body being quite good at achieving homeostasis, the null hypothesis should be what HiThere suggested.

          Do you know of a substance that bind¹ to a thing in the body that doesn't result in down/up regulation of that thing (or something else either upstream or downstream of that said thing) ?

          1-Almost all bioactive substance exerts their's effects by binding to something like a receptor (ex: a dopamine agonists ), an enzyme (ex: a cyp2d6 inhibitor ) , a transporter (ex: a norepinephrine transporter inhibitor), etc....

          --
          I a master of typographic, grammatical and miscellaneous errors !
  • (Score: 0) by Anonymous Coward on Friday January 08 2021, @05:46PM (1 child)

    by Anonymous Coward on Friday January 08 2021, @05:46PM (#1097047)

    Heat oil, and season it with lots of chopped scallion (the white part) and bit of grated ginger.

    • (Score: 0) by Anonymous Coward on Saturday January 09 2021, @01:06AM

      by Anonymous Coward on Saturday January 09 2021, @01:06AM (#1097238)

      Then stand back because it will give you raging boner.

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