Breakthrough study finds age-related cognitive decline may be reversible:
A breakthrough study from a team of neurologists at Stanford University claims to have discovered one way immune cells become dysfunctional as we age, leading to the inflammatory hyperdrive that plays a role in most age-related disease from cancer to cognitive decline. Preliminary study suggests this immune dysfunction can be reversed, pointing to compelling future anti-aging therapies.
[...] The specific focus of the new study, published in the journal Nature, was a hormone called prostaglandin E2 (PGE2). Levels of this particular hormone have previously been found to rise with aging. PGE2 is also known to promote inflammatory activity in immune cells.
[...] Katrin Andreasson, senior author on the new study, calls this age-induced inflammatory mechanism, "a double-whammy – a positive feedback loop."
[...] "Our study suggests that cognitive aging is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restore youthful immune functions," the researchers conclude in the new study.
Also at: Stanford.edu
Journal Reference:
Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing, Nature (DOI: 10.1038/s41586-020-03160-0)
(Score: -1, Troll) by Anonymous Coward on Friday January 22 2021, @03:21AM (4 children)
Lord knows you need the help.
(Score: -1, Troll) by Anonymous Coward on Friday January 22 2021, @03:46AM (3 children)
They were going to test on President Bidet but realized his frequent, life-long cognitive / memory issues only ever occur when he's caught lying.
(Score: 1, Troll) by Anonymous Coward on Friday January 22 2021, @04:19AM (2 children)
Trump lost. Get over it.
Sounds familiar hey, trumptard ?
(Score: -1, Troll) by Anonymous Coward on Friday January 22 2021, @05:07AM
SALUTE THE MARINES!
(Score: 0) by Anonymous Coward on Friday January 22 2021, @11:35PM
Trump was cheated by the swamp monsters. Get a clue!
(Score: 2, Informative) by grumpcuss on Friday January 22 2021, @04:05AM
https://soylentnews.org/article.pl?sid=20/12/15/2151246 [soylentnews.org]
Someplace I saw that a division of Alphabet (aka Google) had licensed the molecule.
(Score: 3, Interesting) by Arik on Friday January 22 2021, @05:16AM (2 children)
I don't want to be buried in a pet cemetery.
If laughter is the best medicine, who are the best doctors?
(Score: 3, Interesting) by crafoo on Friday January 22 2021, @12:11PM (1 child)
It scares me for other reasons. There is something to be said for starting over with a new generation.
Some will say, "we lose so much wisdom!". I don't think they know people all that well. Self-interest, combined with exponentially growing power and wealth is a very scary thing. Thankfully age puts a hard cap on it. Remove that cap and I believe the world quickly becomes a Kafka hellscape of endless suffering.
(Score: 2) by everdred on Friday January 22 2021, @05:12PM
I share your concerns, and I'm not disagreeing with you... but another way to look at it: the age "cap" isn't as hard cap... and as things currently are, cognitive decline typically doesn't remove people from positions of power. (At least not swiftly enough to avoid consequences.) And this might be a stretch, but how much of that self-interest that increases with age can be actually attributed to the cognitive decline? A world where this is put into place would also necessitate a reevaluation of human nature.
(Score: 3, Interesting) by FatPhil on Friday January 22 2021, @10:29AM
The stanford press release took 4 paragraphs before it mentioned mice.
The article based on that took 9 paragraphs.
To be honest, that makes them clickbait. It is an interesting topic, it grabs people's attention, and only once they're invested in reading well past the leader paragraph do you get to the "eventually we might test it on humans, and see if it works on brains which even contain lobes and structures that the mice ones don't, but apart from that are probably really similar, yes, yes, I'm sure, please give us funding" whammy. Thanks for wasting our time. Which is pretty much the definition of clickbait, isn't it?
Just be honest up front, please.
It's in abstract of the paper, to be fair, the hands on pipettes academics are not responsible for this, it's PR departments that are to blame.
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 4, Funny) by nostyle on Friday January 22 2021, @04:53PM (1 child)
If there were no cognitive decline, no-one would be posting on S/N.
In fact, I notice that the cognitive decline of posters is directly proportional to posting frequency.
---
In the future, everyone will live longer for fifteen minutes.
(Score: 1, Insightful) by Anonymous Coward on Friday January 22 2021, @06:19PM
...and how would you find somebody to run for president?
(Score: 0, Funny) by Anonymous Coward on Friday January 22 2021, @05:59PM
Finally some hope for Joe Biden.