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posted by mrpg on Friday April 02 2021, @02:21PM   Printer-friendly

Submitted via IRC for TheMightyBuzzard

Australian researchers have discovered the gene responsible for a particularly nasty form of hormone-sensitive breast cancer. They believe their work may also provide a genetic trail of breadcrumbs to hunt other cancers in future.

[...] Among them were estrogen receptor-positive (ER+) cancers called IntClust2, characterized by a section of DNA in chromosome 11 standing out, with one gene in particular, called AAMDC, a potential calling card for some of the most intractable forms of cancer known to humanity.

Source: Major breakthrough as researchers pinpoint exact gene responsible for one of deadliest forms of breast cancer


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  • (Score: 0) by Anonymous Coward on Friday April 02 2021, @03:14PM (5 children)

    by Anonymous Coward on Friday April 02 2021, @03:14PM (#1132507)

    City of Hope, a research cancer center in Southern California, did studies on blueberries and triple negative breast cancer. They found that compounds in blueberries slowed the tumor growth, and that the compound would enter the body from eating blueberries (i.e., it did not have to be isolated and introduced via IV).

    https://www.cityofhope.org/research/research-overview/superfoods-research/superfoods-blueberries [cityofhope.org]

    Unfortunately, high anti-oxidant foods (e.g., blueberries) may interfere with traditional chemotherapy treatments.

    • (Score: 1, Interesting) by Anonymous Coward on Friday April 02 2021, @04:26PM

      by Anonymous Coward on Friday April 02 2021, @04:26PM (#1132533)

      Chemotherapy = poison. Antioxidants = anti-poison.

      Cancer cells accumulate iron, and high antioxidant levels regenerate ferrous iron from ferric. This kills the high-iron cells via the fenton reaction. There are also various redox-dependent signalling pathways that can take the cell out of proliferation mode, but the fenton reaction is probably the main thing.

    • (Score: 0) by Anonymous Coward on Friday April 02 2021, @04:54PM (3 children)

      by Anonymous Coward on Friday April 02 2021, @04:54PM (#1132544)

      Was it forest grown (or real) blueberries or was it those gigantic blueberries that they sell in the store? Those or more of blue berries then actual blueberries. They taste nothing like the real thing. It's like they crossbreed them with grapes or something. Disgusting.

      • (Score: 3, Insightful) by Joe Desertrat on Friday April 02 2021, @08:38PM (1 child)

        by Joe Desertrat (2454) on Friday April 02 2021, @08:38PM (#1132622)

        Like most store bought produce these days blueberries sold in stores are cultivated for packaging and storage rather than flavor, to the extreme that many artificially blueberry flavored items are closer to the real wild thing in flavor than any "real" blueberries you might find for sale.
        I did a lot of weekend hiking on the Appalachian Trail in NJ for a few years, and during one drought year I came across a patch of wild blueberries. They were tiny, but oh my did they have intense blueberry flavor. Nearly thirty years later I still remember the sensation. I only took a small handful, I figured that the local wildlife needed them and would spread the seeds to grow even more, and I had plenty of food with me.
        In Maine's Baxter State Park on the early stages of the Hunt Trail the blueberries (could have been huckleberries, but close enough) the berries were so thick along the trail you could just grab handfuls of delicious berries as you walked by.
        The store bought berries? I've put them out for birds and even they won't eat them.

      • (Score: 0) by Anonymous Coward on Saturday April 03 2021, @05:42PM

        by Anonymous Coward on Saturday April 03 2021, @05:42PM (#1132923)

        Skip the berries and go straight to purple drank.

  • (Score: 4, Interesting) by kvutza on Friday April 02 2021, @03:29PM

    by kvutza (11959) on Friday April 02 2021, @03:29PM (#1132514)

    Link at Sciencealert [sciencealert.com]

    Hormone treatments work by starving the cancer of the hormones it would use to grow, but extra copies of AAMDC can protect the cancer from this fate.

    Interestingly, this amplification of AAMDC is also found in ovarian, prostate, and lung cancers, so this result might be relevant to other cancer types as well.

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