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posted by martyb on Tuesday June 15 2021, @02:41PM   Printer-friendly
from the worth-a-shot dept.
The Novavax Vaccine Data, and Spike Proteins in General:

Word came yesterday that Novavax had very good safety and efficacy in the trial of their recombinant protein vaccine. This is good news. By this point, the vaccine is much less needed here in the US, but it could be a very important part of getting many other countries vaccinated, due to its less demanding storage requirements and (relatively) straightforward production process. The company does intend to file for FDA approval, and is in the last stages of getting all of its manufacturing and quality control procedures ready for that. I hope that this opens up to worldwide usage of this one, and that the company really is ready for large-scale production.

As many readers are well aware, this is a recombinant protein vaccine, not a viral vector (like J&J or the Oxford/AZ vaccines), and not an mRNA one like Moderna or Pfizer/BioNTech. I also hope that this allays some of the worries that many people still have about those two platforms: recombinant protein vaccines have been around for longer, so this one would (presumably) be less of a concern for some potential users.

It's a long article but well-worth reading as it explores, debunks, and explains many questions that have been posed concerning the spike protein in the virus SARS-CoV-2 which causes in COVID-19.


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  • (Score: -1, Offtopic) by Anonymous Coward on Tuesday June 15 2021, @02:45PM (3 children)

    by Anonymous Coward on Tuesday June 15 2021, @02:45PM (#1145514)

    It's a long article but well-worth reading as it explores, debunks, and explains many questions that have been posed concerning the spike protein in the virus SARS-CoV-2 which causes in COVID-19

    I'm weeping for what this terrible world is going to do to you.

  • (Score: -1, Redundant) by Anonymous Coward on Tuesday June 15 2021, @03:08PM (13 children)

    by Anonymous Coward on Tuesday June 15 2021, @03:08PM (#1145522)

    Maybe not. The whole thing stinks of hair-on-fire ever more corner cutting than usual, masters of the universe at top bellowing that a vaccine will just Solve Everything, mostly because they have some hot shit to sell, might be snake oil, might be dodgy research like with so many other things (*coughSSRIscough*), who cares, just buy my arm jab and make me rich!!

    Well what do you intend to do about the variants? Light everybody's hair on fire, cut more corners, crank out another vaccine, and sell that shot shit and make me rich! I can't find a single fuck to give about your health under the pile of cash in my money bin! No lockdowns to save lives, no sir! The cure, which would deprive me of a 3rd yacht, can't be worse than the fatal disease!

    Maybe if the ownership of the medical system would find some way to prevent the stupid little ritual I go through every other year where a pharmacist religiously objects to my prescriptions, I might feel better about giving them even more of my money. Also, wouldn't it be white privilege if I got vaccinated when there are still so many BIPOCs that need to be vaccinated frist?

    Too much shit flying around to feel safe participating in any of this.

    • (Score: 1, Insightful) by Anonymous Coward on Tuesday June 15 2021, @04:00PM (2 children)

      by Anonymous Coward on Tuesday June 15 2021, @04:00PM (#1145549)

      Then get COVID and die already.

      • (Score: 0) by Anonymous Coward on Tuesday June 15 2021, @06:04PM

        by Anonymous Coward on Tuesday June 15 2021, @06:04PM (#1145606)

        Just give it two more weeks, amirite?

        Anecdata: 100% of the many self-described "immuno-compromised" people I know somehow managed to survive the last year. I'll take my chances.

      • (Score: 0) by Anonymous Coward on Tuesday June 15 2021, @07:10PM

        by Anonymous Coward on Tuesday June 15 2021, @07:10PM (#1145635)

        What a stupid cowardly bitch. You bolshevik scum are going to die from civil war soon.

    • (Score: 3, Insightful) by Anonymous Coward on Tuesday June 15 2021, @04:14PM (5 children)

      by Anonymous Coward on Tuesday June 15 2021, @04:14PM (#1145561)

      Also, wouldn't it be white privilege if I got vaccinated when there are still so many BIPOCs that need to be vaccinated frist?

      How long did that last? Three weeks? They've been trying to give vaccines away to anyone for months now. And you're still acting like a victim?

      • (Score: 3, Insightful) by Anonymous Coward on Tuesday June 15 2021, @04:58PM (4 children)

        by Anonymous Coward on Tuesday June 15 2021, @04:58PM (#1145585)

        Playing the victim is their primary tactic, until they switch to violently oppressive "patriots".

        • (Score: -1, Insightful) by Anonymous Coward on Tuesday June 15 2021, @05:37PM (3 children)

          by Anonymous Coward on Tuesday June 15 2021, @05:37PM (#1145598)

          I can't believe the two posts above this are so deep in their own echo chambers that they fail to recognize irony, mocking such (in a friendly way), that's about as subtle as a sledgehammer to the face. And no, I did not write the original ironic comment.

          • (Score: 2) by DeathMonkey on Tuesday June 15 2021, @06:50PM

            by DeathMonkey (1380) on Tuesday June 15 2021, @06:50PM (#1145626) Journal

            Nope, that's not satire, antivaxxers just always sound that dumb.

          • (Score: 3, Interesting) by Anonymous Coward on Tuesday June 15 2021, @06:56PM (1 child)

            by Anonymous Coward on Tuesday June 15 2021, @06:56PM (#1145631)

            If you did not write the post then you can not claim irony. We're done with the "just a prank bro" excuses for pushing rightwing narratives.

            • (Score: 0) by Anonymous Coward on Wednesday June 16 2021, @05:10AM

              by Anonymous Coward on Wednesday June 16 2021, @05:10AM (#1145771)

              My god you people lack any cognitive ability whatsoever. It only becomes a "rightwing narrative" if you actually understand and appreciate the irony. lol

    • (Score: 1, Flamebait) by JustNiz on Tuesday June 15 2021, @06:42PM

      by JustNiz (1573) on Tuesday June 15 2021, @06:42PM (#1145620)

      > The whole thing stinks of hair-on-fire ever more corner cutting than usual,

      I'd say that's possibly true of Moderna and J&J, but it's a pretty clueless statement to make about Novavax.

    • (Score: 1) by khallow on Wednesday June 16 2021, @02:25AM (2 children)

      by khallow (3766) Subscriber Badge on Wednesday June 16 2021, @02:25AM (#1145732) Journal

      Well what do you intend to do about the variants?

      More vaccination.

      So what's this talk of health? Do you have some sort of evidence that vaccination is worse than getting covid?

      • (Score: 0) by Anonymous Coward on Wednesday June 16 2021, @05:17AM (1 child)

        by Anonymous Coward on Wednesday June 16 2021, @05:17AM (#1145773)

        If herd immunity is reached prematurely some folks may not get the vaccine, which puts everyone at risk.

        • (Score: 1) by khallow on Sunday June 20 2021, @01:33AM

          by khallow (3766) Subscriber Badge on Sunday June 20 2021, @01:33AM (#1147382) Journal

          If herd immunity is reached prematurely some folks may not get the vaccine, which puts everyone at risk.

          They likely won't get the vaccine anyway. We're at the point where everyone who wants the vaccine can get the vaccine. And there's a lot more risk to getting herd immunity by infecting a lot of people than there is to an incomplete vaccination effort.

  • (Score: 2, Interesting) by Anonymous Coward on Tuesday June 15 2021, @03:16PM (12 children)

    by Anonymous Coward on Tuesday June 15 2021, @03:16PM (#1145527)

    Novavax graph [yahoo.com]. $5/share to $200/share in a year. There are so many people getting just unbelievably rich off these vaccines. I'm certain this could never get in the way of politicking, corporate oversight, or "the science" though. You know, like the opioid epidemic that didn't happen.

    Interesting point there. Biden's appointed head of the FDA [wikipedia.org] is Janet Woodcock. During the opioid epidemic she, as the Director of the FDA’s Center for Drug Evaluation and Research, was the lady greenlighting various opioids with minimal safety investigations, and ones that were overwhelmingly rejected by the FDA's advisory committee. She's also the lady that, most recently, also greenlit the alzheimer's drug that doesn't work (and which the advisory committee again overwhelmingly rejected) and will soon be sold for $56k/person/year.

    If somebody is happy to inject themselves with rushed out absurdly profitable drugs that are, by definition, experimental then I fully respect your decision. At the same time, I'll continue to remain a part of the control group. The mixture of misinformation, corruption, and the resultant distrust leaves me much more content to take my chances which given my age, health, and odds of getting the virus, work out to something like 99.9999%.

    • (Score: 0) by Anonymous Coward on Tuesday June 15 2021, @04:02PM (1 child)

      by Anonymous Coward on Tuesday June 15 2021, @04:02PM (#1145552)

      blah blah blah it's all the leftist's fault blah blah blah.

      • (Score: 1, Insightful) by Anonymous Coward on Tuesday June 15 2021, @06:10PM

        by Anonymous Coward on Tuesday June 15 2021, @06:10PM (#1145612)

        If left or right had any meaning when it came to big business and big dollars, that would be comforting - because there would be somebody to shine the light on what's happening. But they are simply two sides of the same coin on this issue, and many like it. When a company is generous with their donations, they become angels beyond reproach. And big pharma is a grand patron of the political class.

    • (Score: 5, Insightful) by Beryllium Sphere (r) on Tuesday June 15 2021, @05:17PM (6 children)

      by Beryllium Sphere (r) (5062) on Tuesday June 15 2021, @05:17PM (#1145596)

      >experimental

      If I let this go unchallenged, I'm an accomplice.

      It's been six months since the mRNA vaccines were even arguably experimental. Then the Phase III trials were completed successfully and the outside advisory panel signed off. That's acceptance testing.

      • (Score: 0, Redundant) by Anonymous Coward on Tuesday June 15 2021, @05:48PM

        by Anonymous Coward on Tuesday June 15 2021, @05:48PM (#1145600)

        This is, somewhat uncharacteristically I must say, incorrect.

        Biologic licensing requires 6 months of data. Pfizer was the first company to apply for approval of their vaccine, and they did say on May 7th, which is safe to assume was the earliest possible date for them to do so. Some random source [nbcnews.com] if, for some reason, you might not trust an AC. That license has still not yet been approved. So yes, all of the vaccines are indeed experimental, again by definition.

      • (Score: 2) by JustNiz on Tuesday June 15 2021, @06:46PM (2 children)

        by JustNiz (1573) on Tuesday June 15 2021, @06:46PM (#1145623)

        You're obviously not considering the possibility of longer term effects.

        • (Score: 0) by Anonymous Coward on Tuesday June 15 2021, @07:13PM

          by Anonymous Coward on Tuesday June 15 2021, @07:13PM (#1145636)

          yeah, as if people are only worried about immediate adverse reactions. i would say this slave is being disingenuous, but they're probably really this dumb.

        • (Score: 2, Informative) by Anonymous Coward on Tuesday June 15 2021, @09:17PM

          by Anonymous Coward on Tuesday June 15 2021, @09:17PM (#1145665)

          You're obviously not considering the possibility of longer term effects.

          Yes, like the covid longtimers suffering for months on end.

          But I'm certain there will be some long term effects of these vaccines. Maybe the IQ of the population will rise a few points after COVID takes a few more runs at the so called 'hesitant'

      • (Score: 2) by Beryllium Sphere (r) on Wednesday June 16 2021, @12:46AM (1 child)

        by Beryllium Sphere (r) (5062) on Wednesday June 16 2021, @12:46AM (#1145706)

        But wait, there's more!

        https://pubmed.ncbi.nlm.nih.gov/18481387/ [nih.gov]

        Injecting mRNA vaccines into humans with proof of safety goes back to 2008 when it was being tried for cancer treatment. Windows 7 had not been released yet, to give you an idea how long ago that was.

        We got the COVID vaccines already because so much work had already been done.

        • (Score: 0) by Anonymous Coward on Wednesday June 16 2021, @07:10AM

          by Anonymous Coward on Wednesday June 16 2021, @07:10AM (#1145789)

          back to 2008 [...] Windows 7 had not been released yet

          In May 2011 Fedora became the first major Linux distribution to enable systemd by default.

          So we'll have to wait ~3 years to find out what terrible terrible things this vaccine caused.

    • (Score: 4, Interesting) by http on Tuesday June 15 2021, @07:05PM (1 child)

      by http (1920) on Tuesday June 15 2021, @07:05PM (#1145634)

      Pharmaceutical companies make money during the largest outbreak of a disease in living memory, how awful! Do complaining about air conditioning manufacturers making money during a heat wave next.

      Remaining part of the control group is suicide bomber style.

      --
      I browse at -1 when I have mod points. It's unsettling.
      • (Score: -1, Troll) by Anonymous Coward on Wednesday June 16 2021, @05:07AM

        by Anonymous Coward on Wednesday June 16 2021, @05:07AM (#1145770)

        Do please show me the air conditioning company who's stock went up 4000% during a heat wave. What we're seeing now is profiteering made even worse because the profiteering is being largely facilitated by the government. So it's profiteering and large scale corruption combined.

        In the UK, of the 42 people who have died of the latest variant, 29% were fully vaccinated. That still shows some degree of effectiveness since about 54% of the entire population is fully vaccinated and so nominally you'd expect 54% of those deaths to be fully vaccinated if the vaccines had a 0% rate of effectiveness, but on the other hand.. that's a terrible rate of effectiveness. And so you're taking on the risk of using experimental vaccines which have shown a tremendous number of adverse reactions, which we continue to find new short-term consequences of, and for whom long-term effects have not even yet begun to be able to be determined, and you'll probably still die anyhow if you're in a high risk group especially as more variants of COVID emerge.

        COVID has a mortality rate of extremely near 0% for those under the age of 50 and in otherwise good health. My 99.9999% odds were not an exaggeration but likely an understatement. The exact figure is difficult to derive since I'm unable to find the exact number of cases without any preconditions, other than to say it is extremely low. It is likely much closer to 99.999999% but at this point pushing the decimal places further doesn't really achieve much beyond looking like hyperbole - even though it is not.

    • (Score: 0) by Anonymous Coward on Wednesday June 16 2021, @02:14AM

      by Anonymous Coward on Wednesday June 16 2021, @02:14AM (#1145730)

      > If somebody is happy to inject themselves with rushed out absurdly profitable drugs that are, by definition, experimental then I fully respect your decision.

      Having a terminal illness is one of those things that breeds desperation.

      Desperate people will grasp at almost anything.

      I think some of the lax approval process is due to the strong criticisms that were leveled against the agency for the last several years, that the FDA was being too restrictive, and causing unnecessary death and suffering by withholding possibly effective treatments. Seems the pendulum has swung a bit too far with drugs that showed no efficacy in trials being approved-- that one really does scream corruption.

  • (Score: 0) by Anonymous Coward on Tuesday June 15 2021, @03:37PM (2 children)

    by Anonymous Coward on Tuesday June 15 2021, @03:37PM (#1145537)

    Asking for my friend Jenny.

    • (Score: 1, Funny) by Anonymous Coward on Tuesday June 15 2021, @04:53PM (1 child)

      by Anonymous Coward on Tuesday June 15 2021, @04:53PM (#1145582)

      She hasn't changed her phone number, has she?

      • (Score: 2) by Farmer Tim on Wednesday June 16 2021, @12:49AM

        by Farmer Tim (6490) on Wednesday June 16 2021, @12:49AM (#1145707)
        It’s still 867 5309. YouTube told me so.
        --
        Came for the news, stayed for the soap opera.
  • (Score: 2) by DannyB on Tuesday June 15 2021, @03:53PM

    by DannyB (5839) Subscriber Badge on Tuesday June 15 2021, @03:53PM (#1145546) Journal

    Aren't we trying to shut down pipelines now?

    --
    People today are educated enough to repeat what they are taught but not to question what they are taught.
  • (Score: 2) by Beryllium Sphere (r) on Tuesday June 15 2021, @04:59PM

    by Beryllium Sphere (r) (5062) on Tuesday June 15 2021, @04:59PM (#1145586)

    Spike protein seemed like the kind of thing lab supply companies might sell, and if you sell a chemical you need to supply a Material Safety Data Sheet listing whether it's flammable, corrosive, or toxic. Off to Google.

    https://www.emdmillipore.com/US/en/product/msds/MM_NF-AGX818 [emdmillipore.com]

    The animal studies were safety studies. Humans sometimes react differently, which is why we do Phase I safety studies on humans before giving a new treatment to large numbers of us. The results were clear.

  • (Score: 4, Informative) by Beryllium Sphere (r) on Tuesday June 15 2021, @05:13PM (1 child)

    by Beryllium Sphere (r) (5062) on Tuesday June 15 2021, @05:13PM (#1145594)

    The efficacy is a delight.

    The immune system evolved to handle things that settled in and produced antigen for days. It's great that it can also react to a single dose, but I did see a paper that found limits on the response to another protein subunit vaccine.

    I can't find the link again in the time I'm willing to spend, but what they found was that mRNA vaccines produced a much stronger response in the T follicular helper cell subsystem than protein subunit vaccines. Unless the proteins were administered by infusion over days.

    But, "the proof of the pudding" is here. 100% against moderate to severe cases speaks for itself. And the logistical advantage is compelling until we get freeze-dried COVID mRNA vaccines.

    I hope production is easy to scale up.

  • (Score: -1, Troll) by Anonymous Coward on Wednesday June 16 2021, @01:49PM (1 child)

    by Anonymous Coward on Wednesday June 16 2021, @01:49PM (#1145892)

    "Beryllium Sphere" is getting paid a lot of shekels to be a cheerleader and innoculate everyone who reads against thinking.

    Im so glad I left this site, it's now a shameful propaganda reflector.

    The admins must be TLA's or cops of some kind, there is no other explanation.

    >story has changed dozens of times
    >10 different injections against a single virus
    >virus has already changed to make original injections worthless
    >hundreds of thousands of bizarre and/or deadly adverse reactions
    >cloth masks don't slow down virus sized particles
    >lockdowns made no change to virus velocity, and are only even theoretically effective for short terms

    This echo chamber should shut down, it is pure shamelessness.

    Plus the CRT shilling in the journals, what cancer on the world this place is.

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