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posted by martyb on Monday September 13, @04:27AM   Printer-friendly [Skip to comment(s)]

NIH scientists identify nutrient that helps prevent bacterial infection:

NIH scientists identify nutrient that helps prevent bacterial infection

Scientists know that microbiota — the trillions of beneficial microbes living harmoniously inside our gut — can protect people from bacterial infections, but little is known about how they provide protection. Scientists are studying the microbiota with an eye to finding or enhancing natural treatments to replace antibiotics, which harm microbiota and become less effective as bacteria develop drug resistance.

The scientists observed that microbiota that had experienced prior infection and transferred to germ-free mice helped prevent infection with Kpn. They identified a class of bacteria — Deltaproteobacteria— involved in fighting these infections, and further analysis led them to identify taurine as the trigger for Deltaproteobacteria activity.

Taurine helps the body digest fats and oils and is found naturally in bile acids in the gut. The poisonous gas hydrogen sulfide is a byproduct of taurine. The scientists believe that low levels of taurine allow pathogens to colonize the gut, but high levels produce enough hydrogen sulfide to prevent colonization. During the study, the researchers realized that a single mild infection is sufficient to prepare the microbiota to resist subsequent infection, and that the liver and gallbladder — which synthesize and store bile acids containing taurine — can develop long-term infection protection.

The study found that taurine given to mice as a supplement in drinking water also prepared the microbiota to prevent infection. However, when mice drank water containing bismuth subsalicylate — a common over-the-counter drug used to treat diarrhea and upset stomach — infection protection waned because bismuth inhibits hydrogen sulfide production.

Journal Reference:
Redirecting, (DOI: 10.1016/j.cell.2020.12.011)


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  • (Score: 2) by Rich on Monday September 13, @09:33AM (1 child)

    by Rich (945) on Monday September 13, @09:33AM (#1177381) Journal

    Does this research imply that the tacky gummy bear smell of Red Bull ends up as most vile fart stink?

    • (Score: 1, Flamebait) by aristarchus on Monday September 13, @09:25PM

      by aristarchus (2645) on Monday September 13, @09:25PM (#1177506) Journal

      Thinly veiled advertisement for Reb Dull. No mention of the near lethal doses of caffeine that it is paired with. And a dis-ad for Pepto-Bismol. Interesting. Who fell for this?

      --
      FatPhil: "F**k me, ran out of all of today's modpoints in just 10 minutes. "
  • (Score: 0) by Anonymous Coward on Tuesday September 14, @04:29AM

    by Anonymous Coward on Tuesday September 14, @04:29AM (#1177605)

    Please pleas please blow me somebody!

  • (Score: 2) by gawdonblue on Tuesday September 14, @07:34AM

    by gawdonblue (412) on Tuesday September 14, @07:34AM (#1177635)

    Didn't know what "NIH" stood for so I looked it up: "Not Invented Here".

    The US government really does have a department for everything!

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