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posted by janrinok on Thursday June 02 2022, @10:21AM   Printer-friendly
from the but-when-I-do-that.... dept.

Phys.org:

The researchers successfully increased the level of THC (tetrahydrocannabinol), the main psychoactive component in cannabis, by close to 17%, and the level of CBG (cannabigerol), often referred to as the mother of all cannabinoids, by close to 25%. Further, Vainstein and his team were able to increase the ratio of terpenes, which are responsible for maximizing the euphoric effects of cannabis, by 20–30%.

The stated goal of their study was to find a way to intervene in the biochemical pathways in the cannabis plant in order to increase or decrease the production of active substances. The researchers accomplished this by manipulating a plant-based virus, that had first been neutralized so that it could not harm the plant, and then manipulating it to express the genes that influence the production of active substances in the cannabis plant.

See also: Metabolic 'fingerprint' predicts impairment from medical cannabis

Perhaps the research can lead to a new class of drugs as an alternative to opioid-based pain management.


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  • (Score: -1, Offtopic) by Anonymous Coward on Thursday June 02 2022, @10:35AM

    by Anonymous Coward on Thursday June 02 2022, @10:35AM (#1249683)

    Yes, I'm trying to force-meme the Subject line joke.

  • (Score: -1, Flamebait) by Anonymous Coward on Thursday June 02 2022, @11:02AM (5 children)

    by Anonymous Coward on Thursday June 02 2022, @11:02AM (#1249686)

    The researchers accomplished this by manipulating a plant-based virus, that had first been neutralized so that it could not harm the plant, and then manipulating it to express the genes that influence the production of active substances in the cannabis plant.

    Pretty standard method if you ask me (/me got some degrees in plant biotechnology). But then again... the goal as stated seems to me to have little academic value.

    • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @11:14AM (1 child)

      by Anonymous Coward on Thursday June 02 2022, @11:14AM (#1249694)

      Yeah, I thought that careful plant breeding had already greatly increased the potency of weed.

      • (Score: 1, Informative) by Anonymous Coward on Thursday June 02 2022, @01:01PM

        by Anonymous Coward on Thursday June 02 2022, @01:01PM (#1249721)

        Most virus-based "manipulations", and I guess it's the case here as well, result in transient expression of genes. This is temporarily and isn't carried over into the offspring. It's much faster than breeding, which can take years to get good plant lines.

    • (Score: 5, Insightful) by FatPhil on Thursday June 02 2022, @11:32AM (2 children)

      by FatPhil (863) <{pc-soylent} {at} {asdf.fi}> on Thursday June 02 2022, @11:32AM (#1249699) Homepage
      Given that they don't claim it's a novel technique, you coming here and saying "but it's not a novel technique" adds nothing. More than 99.9% of science is just modifying the use of an old technique. The next researchers might use a different virus, or a different modification, or a different variant of cannabis.

      How many of the dots on this chart would you claim have no academic value:
          https://upload.wikimedia.org/wikipedia/commons/b/bb/Timeline_of_Superconductivity_from_1900_to_2015.svg
      or, even "worse", this:
          https://upload.wikimedia.org/wikipedia/commons/2/25/Best-research-cell-efficiencies-rev220126_pages-to-jpg-0001.jpg
      ?
      --
      Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
      • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @12:56PM (1 child)

        by Anonymous Coward on Thursday June 02 2022, @12:56PM (#1249720)

        OP here. Don't get me wrong, replicating an experiment or just modifying one variable can be relevant scientifically (like in your linked charts), but IMHO it needs to be part of a larger research that adds new insights. Doing something where you already know what the outcome will be (or what you target for), is hardly newsworthy in my opinion. The stated goal has been done before and it is pretty well known what works and what not.

        Using a standard/proven technique isn't the problem here, and a well known biochemical pathway neither, but please add something that advances science if you're going to use research funds for that.

        P.S. Note I use "adds little" instead if "adds nothing". No experiment "adds nothing", we can always learn something from an experiment. If it should catch the news, that's what this discussion is about.

        • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @10:28PM

          by Anonymous Coward on Thursday June 02 2022, @10:28PM (#1249988)

          Valuable work, friend.

          Science has become this kind of cost-benefit analysis with about 90% of funds used to determine allocation of funds, management of funds, discussion of methods of measurement of effectiveness of funds. In other words, what used to be science is now almost totally managers bickering among themselves.

          When a million dollars is spent on a project, probably the only the last $50k to 60k goes on doing actual science, typically squeezing a junior post doc to come up with an idea (or make the shit management came up with actually work).

          Paraphrasing Thoreau: There are no longer physicists, there are only professors of physics.

  • (Score: 4, Interesting) by Rosco P. Coltrane on Thursday June 02 2022, @11:36AM (16 children)

    by Rosco P. Coltrane (4757) on Thursday June 02 2022, @11:36AM (#1249700)

    You know what? When I was a teenager in the 80's, I smoked truckloads of spliffs. And then as life took me other places, I quit smoking cannabis.

    A few years ago, after I had quit smoking and switched to vaping for quite some time, I discovered dry herb vaporizers. So I bought a cheap one, and a couple of bulbs from a friends who had a small growing thing going.

    The first thing I noticed was all that white, greasy stuff on the bulbs. We didn't have that when I was a kid: the stuff we smoked was mostly dry.
    And then I vaped maybe 1/4g for 10 minutes, without any hit.
    And then I got hit by the mother of all sea-sickness. It lasted for 10 hours straight. My wife told me later she was about to call an ambulance because I looked so pale.

    This engineered stuff was nothing like the innocent stuff we had when I was a kid. I imagine the "enhanced" stuff in TFA is even worse. If you can smoke or vape that, good for you. I know I can't: it's just too potent and not enjoyable at all.

    • (Score: 5, Interesting) by Anonymous Coward on Thursday June 02 2022, @12:00PM (9 children)

      by Anonymous Coward on Thursday June 02 2022, @12:00PM (#1249704)

      With all due respect, the stuff these days is not, 'hard stuff,' anymore than 40 proof liquor is hard by comparison to a beer or glass of wine.

      It sounds like what you did, was treat a bottle of whiskey like it was a beer. And unfortunately, that's a very, very common mistake, people make, with not only cannabis, but any drug, that isn't alcohol. And that's just ignorance on the part of users, it's not the fault of the, 'substance.'

      The reason people make mistakes like this, quite often, is because A: people are not so bright a lot of the time; or B: they are uninformed.

      The reason people, 'generally,' (but even then, not always), are able to accurately gauge their dosage of alcohol, is because the taste buds tend to inform the user, quite immediately, of the potency/strength of the dosage.

      Now, one place where I agree with you, is that, maximizing the psychoactive constituent yield of cannabis, does NOT need to be the goal. However, very often, people tend to think Bigger is better, and More is more. This is not, however, the case. The more experienced of us, know that, often times, 'less is more.'

      If I was in the cannabis business, my main goal would be to provide the largest variety of strains that I can. I'd also possibly try to provide different THC percentages. But, by and large, the percentage of THC to plant material is not always, and not even often, having much to do with the genetics; it also has a lot to do with how well the plant was grown. You could have the most potent of potent cannabis strains, but grow it in very limiting conditions, and it just won't have the chance to produce alot of those psychoactives.

      Seasons smokers know, however, that a higher % of THC, is a good thing, because you don't have to smoke as much plant material to get the same effect. It's a win win for everyone at that point.

      That being said, if you haven't smoked in a decade, and you buy something that is 17% psychoactive: DO NOT ROLL A JOINT AND SMOKE THE WHOLE THING. If you MUST roll a joint. Take ONE hit, wait 5 minutes, and see how you feel; and please, make it a SMALL hit...

      As for genetically modified cannabis, it is sure to come; but, I view it as blasphemy to the sacredness of the cannabis plant. But, for some, there is nothing more sacred than the all-mighty dollar...

      Sorry you had a bad trip, take it easy, be careful, read the manual :) :p

      • (Score: 3, Touché) by Anonymous Coward on Thursday June 02 2022, @12:15PM (1 child)

        by Anonymous Coward on Thursday June 02 2022, @12:15PM (#1249706)

        Everclear for all drinkers! Great for the youths. Don't waste time drinking Dad's beer. It will just bloat you.

        • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @10:34PM

          by Anonymous Coward on Thursday June 02 2022, @10:34PM (#1249993)

          What are you a fucking health nut? Straight to the methylated spirits, and if that's too fancy-schmancy for you then huff gasoline.

      • (Score: 2) by FatPhil on Thursday June 02 2022, @01:34PM

        by FatPhil (863) <{pc-soylent} {at} {asdf.fi}> on Thursday June 02 2022, @01:34PM (#1249727) Homepage
        > the stuff these days is not, 'hard stuff,' anymore than 40 proof liquor is hard by comparison to a beer or glass of wine.

        But 40 proof liquor is hard in comparision to a beer or a glass of wine. Every single jurisdiction I know of, and I've travelled a fair bit, and drunk all sorts in all of those places, has different licensing laws for hard liquor and weaker alcoholic beverages. The exact cutoffs may vary, typically 18% or 20% ABV, but they all separate the spirits from the beers and wines.

        Your argument may have been better if you'd have said "... any more than Goose Island Bourbon County Brand Stout is hard by comparison to a Guinness", as then you'd have been comparing like with like.
        --
        Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
      • (Score: 3, Interesting) by quietus on Thursday June 02 2022, @06:02PM (2 children)

        by quietus (6328) on Thursday June 02 2022, @06:02PM (#1249861) Journal

        Hmm. This is anecdotical but, according to a niece of mine, genetically engineered weed is already here (Belgium/the Netherlands -- where the weed is called Nederwiet). According to her, the new weed is nothing like the weed that was smoked 10, 15 years ago, but more comparable to heroin [of that time period].

        (It is not unusual to find discarded drums of chemicals dumped in ditches around here, nor of rented garages, farm hangars and the like suddenly burning out with fumes toxic enough to necessitate evacuating the neighborhood. Interestingly, most of those operations seem to be made-to-order the last years, with the orders [and the occasional killer] coming in from Latin America.)

        • (Score: 0) by Anonymous Coward on Friday June 03 2022, @12:08AM (1 child)

          by Anonymous Coward on Friday June 03 2022, @12:08AM (#1250017)

          Sounds like meth labs, and your niece should really get that weed tested because it is much more likely laced with other drugs to get buyers actually addicted, or to make their shit weed seem better. Probably the latter, Netherlands isn't the best locale for growing weed.

          • (Score: 2) by quietus on Saturday June 04 2022, @12:46PM

            by quietus (6328) on Saturday June 04 2022, @12:46PM (#1250478) Journal

            I don't know of any weed being grown in the open air, except with amateurs, on a very small scale. These days plantations are greenhouses with controlled lighting, water, temperature and -- one assumes -- precise doses of plant growth hormones.

            It's not meth labs, but synthetic designer drug labs (aka the umptieth generation of XTC). Coincidentally, yesterday pink Super Mario design XTC tablets containing 300mg MDMA have been found at a local music festival. That's 4 times as much as normal -- with a safe dosis being 125mg apparently: higher than that, and you've got a serious chance of burning up from the inside (or at least, that's the feeling).

      • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @11:14PM

        by Anonymous Coward on Thursday June 02 2022, @11:14PM (#1250011)

        Back in the 1980s I was treated to some Marijuana grown in a sugarcane field in Hawaii, it was the best I ever had. I quit smoking weed until recently and tried all kinds with varying results. The best new stuff was Afghani Gold... It's a creeper... You want to stop getting any higher but it still creeps up even more. TBL... You get what you pay for.

      • (Score: 2) by mcgrew on Friday June 03 2022, @12:10AM (1 child)

        by mcgrew (701) <publish@mcgrewbooks.com> on Friday June 03 2022, @12:10AM (#1250019) Homepage Journal

        It sounds like what you did, was treat a bottle of whiskey like it was a beer.

        Exactly. Today's pot (not the engineered weed) is a whole lot better than 1975's, but the best weed I ever smoked was between August 1973 and August 1974 when I was in Thailand. Thai stick was like today's weed; all seedless bud.

        But here at home, an ounce of weed was an ounce of the whole plant. Stems, seeds, leaves, and buds. Most of us separated the bud from the shake, but the bud was half as good as Thai stick.

        But an old fellow in a bar told me he used to pretty much stay high in his youth, then stopped when they started drug testing. When he retired he decided to get high again, and found somebody to sell him a joint. He was surprised it was five bucks (two for a dollar in the Kiel Auditorium rest room in 1978) and smoked the whole joint at once!

        "I'm done smokin' pot," he said. I laughed my ass off.

        --
        Carbon, The only element in the known universe to ever gain sentience
    • (Score: 3, Interesting) by Thexalon on Thursday June 02 2022, @12:16PM (1 child)

      by Thexalon (636) Subscriber Badge on Thursday June 02 2022, @12:16PM (#1249707)

      All I know for sure is:
      1. All my stoner friends are essentially fine. I don't smoke the sticky icky myself, but they do, a lot, and do not appear to have any long-term health effects for doing so.
      2. Even today's dope doesn't appear to be any more dangerous than alcohol, caffeine, or sugar. And I'd definitely much rather somebody be on pot than on opioids.

      Obviously, for more potent stuff, use less of it to get the same dosage. Which still makes the more potent stuff useful, because it's less to grow, harvest, and transport.

      --
      The only thing that stops a bad guy with a compiler is a good guy with a compiler.
      • (Score: 1, Funny) by Anonymous Coward on Friday June 03 2022, @02:50PM

        by Anonymous Coward on Friday June 03 2022, @02:50PM (#1250241)

        Wait... drugs ain't bad??? Fuck, next you'll be telling me gay marriage won't bring down civilization.

    • (Score: 2) by Michael on Thursday June 02 2022, @08:30PM (3 children)

      by Michael (7157) on Thursday June 02 2022, @08:30PM (#1249951)

      The near-instantaneous hit from rolled joints is not thc at all, it's carbon monoxide (and even more powerfully, nicotine, if you add tobacco).

      Without that immediate and detectable physiological response, you severely over-dosed yourself. You probably had a hundred times more thc in one go than your (unpractised) tolerance warranted. Compared to your previous tolerance, old-fashioned cannabis strength, and the inefficiency of joints, it was probably the equivalent of a blunt the diameter of your wrist. If that had happened with most drugs you'd be dead, so if you decide to experiment in future, please consider titration.

      As far as your unpleasant side effects, they sound like low blood glucose. Under conditions of extreme overdose this can be intense enough to be very debilitating. Typical acute hypoglycemia symptoms are shaking, nausea, pallor, anxiety, sweating, palpitations, tingling in the lips and extremities, disorientation and blurred vision.

      I'd wager if you'd drank a pint of over-sweetened tea immediately, you'd have felt much better physically (but as high as a kite for hours).

      Similar thing happened to a guy who tried honey oil (purified extract) for the first time when I was a student. He was a bit heavy handed with it and literally started talking about an ambulance because he thought he was having a heart attack, then after a sweet drink and five minutes quiet rest he was fine and went straight back to mario cart.

      • (Score: 2) by mcgrew on Friday June 03 2022, @12:18AM (2 children)

        by mcgrew (701) <publish@mcgrewbooks.com> on Friday June 03 2022, @12:18AM (#1250022) Homepage Journal

        The near-instantaneous hit from rolled joints is not thc at all, it's carbon monoxide

        And you can cite a study showing that today's weed releases far more Co than 1970s' but no more THC? Because I find that preposterous statement to need some rock hard proof to in any way even consider believing it.

        --
        Carbon, The only element in the known universe to ever gain sentience
        • (Score: 2) by Michael on Sunday June 05 2022, @01:23PM (1 child)

          by Michael (7157) on Sunday June 05 2022, @01:23PM (#1250667)

          I can't see how you got that from what I said.

          The comparison was smoking lots of combustion-based joints versus a single hit from a (non-combustion) vape.

          The point was that the CO (and maybe nicotine) from joints hits you before the thc does, so you feel that first.

          With a vape there's no CO or nicotine, so you don't get the same advanced warning until it's too late. Nobody is going to smoke 100 joints in ten minutes and then be surprised they've had too much thc. (Their throat would be barbecued and they'd pass out from CO poisoning.) With strong cannabis in a vape it's easy to absorb that same amount of thc and not even realise it until ten minuted later, because the parts you feel immediately aren't present at all.

          • (Score: 2) by mcgrew on Wednesday June 15 2022, @02:29PM

            by mcgrew (701) <publish@mcgrewbooks.com> on Wednesday June 15 2022, @02:29PM (#1253425) Homepage Journal

            The comparison was smoking lots of combustion-based joints versus a single hit from a (non-combustion) vape.

            I see you're not a user. One hit from a joint will give you the same high as one hit from a vape, but vaping has killed people; not from THC but from other stuff in the vape, like vitamin E, which ruined lungs. Some people died, some needed lung transplants. Nobody has ever died from smoking a joint.

            The point was that the CO (and maybe nicotine) from joints hits you before the THC does, so you feel that first.

            *sigh* Cannabis contains no nicotine in any form, and carbon monoxide doesn't give any kind of high. Symptoms of CO poisoning are flu-like. Your great ignorance isn't appalling, but the fact that you're ignorant of your ignorance is. It's obvious that you have never smoked a bit of weed or read a single book on the subject.

            Educate yourself or please STFU, I see enough ignorant talk on Facebook without seeing it here.

            --
            Carbon, The only element in the known universe to ever gain sentience
  • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @12:17PM (5 children)

    by Anonymous Coward on Thursday June 02 2022, @12:17PM (#1249708)

    Researchers did not say why they are doing this.

    • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @12:23PM

      by Anonymous Coward on Thursday June 02 2022, @12:23PM (#1249712)

      Now I am become Dude Weed, the destroyer of foods.

    • (Score: 2, Funny) by Anonymous Coward on Thursday June 02 2022, @01:45PM (1 child)

      by Anonymous Coward on Thursday June 02 2022, @01:45PM (#1249733)

      Kill voter brain cells, improve Democrat chances at the polls.

      • (Score: 3, Interesting) by HiThere on Thursday June 02 2022, @01:55PM

        by HiThere (866) on Thursday June 02 2022, @01:55PM (#1249740) Journal

        IIRC, one of the bad effects of cannabis is that it stops the brain from killing off unused cells. This is supposed to happen during the late teens to early 20's, and cannabis was reported to interfere with the process. I forget just what you should search for to find that article, but one of the key words is
        "pruning".

        --
        Javascript is what you use to allow unknown third parties to run software you have no idea about on your computer.
    • (Score: 2) by janrinok on Thursday June 02 2022, @03:42PM

      by janrinok (52) Subscriber Badge on Thursday June 02 2022, @03:42PM (#1249774) Journal

      Researchers did not say why they are doing this.

      Unless you read the linked material:

      Currently, there is a great deal of research activity aimed at identifying additional substances and medical treatments that can be derived from the cannabis plant, in addition to the more than 200 active ingredients that have already been identified. Until now, there had been no way to tailor strains to produce certain cannabis substances or to alter the ratio between them. According to Vainstein, "These study results will be valuable both to industry—to increase the yield of active substances, and to medical researcher—to cultivate and develop new strains for medical cannabis users."

    • (Score: 2) by mcgrew on Friday June 03 2022, @12:20AM

      by mcgrew (701) <publish@mcgrewbooks.com> on Friday June 03 2022, @12:20AM (#1250025) Homepage Journal

      Seldom do I see a comment on S/N that warrants a "well DUH!"

      They like getting high. Are you drunk or something?

      --
      Carbon, The only element in the known universe to ever gain sentience
  • (Score: -1, Offtopic) by Anonymous Coward on Thursday June 02 2022, @12:33PM (8 children)

    by Anonymous Coward on Thursday June 02 2022, @12:33PM (#1249716)

    and you eventually ban the entire Internet.

    But maybe you get a little timeout until the next post just to drive home the point and keep you guessing.

    Cause all that banning is just going to piss off the actual contributors to this site and convert them into spammers.

    Good fucking luck with your little power struggle.
    Don't want to hurt your little feelers!

    • (Score: 2) by janrinok on Thursday June 02 2022, @03:44PM (7 children)

      by janrinok (52) Subscriber Badge on Thursday June 02 2022, @03:44PM (#1249777) Journal

      We haven't banned anything.

      • (Score: -1, Flamebait) by Anonymous Coward on Thursday June 02 2022, @03:54PM (6 children)

        by Anonymous Coward on Thursday June 02 2022, @03:54PM (#1249782)

        Yes you have because you run the site and allow other users to ban via the spam mod. Your culpability is made clear when you reverse some spam mods. Not that I think the spam mod is terrible, or that you should for sure remove it, but don't evade responsibility. You do know apk weaponizes the spam mod to irritate people while spamming his racist rants?

        • (Score: 5, Informative) by janrinok on Thursday June 02 2022, @05:03PM (5 children)

          by janrinok (52) Subscriber Badge on Thursday June 02 2022, @05:03PM (#1249830) Journal
          1. Today I have reverted 3 spam moderations. If they are not justified, we revert them. We did not make the initial moderations - they were done by community members. We are not responsible for the actions of community members. If you have a complaint about a moderation you can contact us on admin [at] soylentnews.org. If you don't contact us then we will assume that you are not interested in getting the moderations reverted. It is YOUR responsibility.
          2. apk has not used his account since 10 July 2014. Therefore he cannot be moderating anybody's comments using that account. You are talking rubbish. apk posts as an AC just as you are doing now.
          3. Every moderation is by a logged in user. If you wish to challenge a specific moderation then contact us at the email I gave earlier.

          Note than none of these have anything to do with IP addresses, but with moderations.

          Now, if you are being blocked by the server then it is usually because too many of the posts submitted from that IP address are being downmodded. If it isn't you, then all you have to do is change your IP address. If it is you - then what do you expect to happen?

          It appears that you do not understand how websites work, how servers work, or how the internet works. Congratulations on actually making a comment despite your obvious ignorance.

          • (Score: -1, Offtopic) by Anonymous Coward on Thursday June 02 2022, @06:01PM

            by Anonymous Coward on Thursday June 02 2022, @06:01PM (#1249860)

            This blocking of IPs might be more fair if there were serious lasting repercussions for these dumb slaves knowingly modding things they think they disagree with (they don't actually know anything about what they are modding against) as spam just to get IPs blocked and censor.

          • (Score: -1, Offtopic) by Anonymous Coward on Friday June 03 2022, @12:18AM (3 children)

            by Anonymous Coward on Friday June 03 2022, @12:18AM (#1250023)

            As usual you intentionally miss the point which is clear from you affirming it with your #1. #2 makes you look a little senile, but I'll take some blame for unclear communication. He weaponizes spam mods by posting racist hate rants to get as many IPs banned as possible, and look he even gave you a reply whinging about the downmods his racist posts receive. He wants to be the pitcher, not the catcher! Since people stopped reflexively moderating liberal AC comments as spam I haven't received any that I know of, but have seen a couple of abusive mods probably targeting a suspected aristarchus post or one of his new sock puppets. Thanks for the email, if I have a problem I'd like to hide from the site users I'll get right on it.

            • (Score: 2, Informative) by janrinok on Friday June 03 2022, @05:08AM (2 children)

              by janrinok (52) Subscriber Badge on Friday June 03 2022, @05:08AM (#1250114) Journal

              As usual you intentionally miss the point which is clear from you affirming it with your #1

              If somebody repeatedly moderates unfairly they receive a moderation ban. What are you suggesting we should do instead?

              #2 makes you look a little senile, but I'll take some blame for unclear communication.

              and look he even gave you a reply whinging about the downmods his racist posts receive

              So how do you know that it is apk? And which reply are you referring to? We have several ACs who regularly pretend to be somebody else. I have even had an AC claiming to be me.

              targeting a suspected aristarchus post or one of his new sock puppets

              How do you know that they are sock-puppets, or that the same person who created the aristarchus account is controlling them? You seem to be very sure that you can identify ACs. However, aristarchus' posts ARE Spam - that was stated in the Decision banning him.

              We cannot read every comment posted. We spend far more time preparing new stories and other editorial tasks than we do administrating the site. If you think you have found irregular moderation or identified a sock-puppet let us know please. We cannot take any action unless we know about such things, can we?

              • (Score: 3, Interesting) by Joe Desertrat on Sunday June 05 2022, @12:01AM (1 child)

                by Joe Desertrat (2454) on Sunday June 05 2022, @12:01AM (#1250570)

                I really wish you didn't feel the need to respond in detail to that sort of complainer. You and the others running this site have enough to do. I, for one, am grateful for it. I think most of us feel you do a fine job of it, especially considering the "pay". Maybe make up a page of FWC's (Frequently Whined Complaints), and link each of those sort of posts to the appropriate response and save your energy for the important stuff?

                Here's a clue, posters. The site warns you if you are misusing a type of moderation (at least it did, I haven't run afoul of it in a long time) when you try to post. Try posting well thought out responses instead of reactionary quips. If your argument has merit people will respond in a like manner, even if disagreeing with the merits of your post. I enjoy seeing genuine "arguments" (not just the automatic gainsaying of comments). I see too many posts that just put down the OP instead of countering their comments. That adds nothing to the discussion, and makes any arguments you do make less likely to be taken seriously.

                • (Score: 2) by janrinok on Sunday June 05 2022, @05:59AM

                  by janrinok (52) Subscriber Badge on Sunday June 05 2022, @05:59AM (#1250637) Journal

                  Thank you - some interesting suggestions. However, if we do not respond then we run the risk of being accused of doing nothing or not answering to the community. We will have to find the right balance.

  • (Score: 1, Interesting) by Anonymous Coward on Thursday June 02 2022, @05:53PM (3 children)

    by Anonymous Coward on Thursday June 02 2022, @05:53PM (#1249853)

    I've only smoked it a few times, and the only time it was ever any good to me was in the 80s--the first time. Everybody said you don't get high the first time, but I did. I remember being disappointed that I couldn't see leaves. It was early "bud". They were just calling it sinsemilla. This dude's brother got it all the way from California to the east coast.

    Anyhow, flash forward 30 years and I tried the modern stuff. It made me feel like I was on a boat at sea and I was about to die of sea-sickness. Fuck that.

    I'm not the only one. Some friends of my sister who used to smoke all the time tried the modern stuff and it ruined their weekend--made them all paranoid.

    There's a market for weaker weed, "classic" strains that go back to the good ol' days--either leaves, or really mild flower might sell to us 50-somethings; but I don't care.

    I'm glad that fewer people are going to jail for it now; but it's still a vice and I don't need it. So maybe it's just fine that the rest of y'all are doing to weed what people did to hot peppers.

    Just be mindful that legal or not, this can't be good for your health.

    • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @10:43PM (2 children)

      by Anonymous Coward on Thursday June 02 2022, @10:43PM (#1249999)

      > There's a market for weaker weed

      For fuck's sake, you can ask for it at the store. Stop bitching about "SUPER STRONK WE3D OMG BANZOR" and buy what you fucking want instead of the strong stuff. I bet your gay friends didn't accidentally drink cans of vodka instead of beer, or drop 10 acid tabs, or inject meth and complain about getting high. Dumbasses.

      • (Score: 0) by Anonymous Coward on Friday June 03 2022, @02:28AM (1 child)

        by Anonymous Coward on Friday June 03 2022, @02:28AM (#1250065)

        top level AC here. I literally only bought it once, and it wasn't even legal then. "Give me $10, and I'll keep you high tonight". The guy delivered--shared bong session for everybody that threw in, and a joint for later. 2nd best experience, but also in the 80s. When you're with weed smokers, they're going to share out what they've got. It's all "STRONK" now. Last time, I had them load 1/3rd of their usual and I took one hit. It might have been a deep hit, but that shouldn't have mattered so much. It sucked, and the only realistic way to cut it is with tobacco which I don't want.

        • (Score: 0) by Anonymous Coward on Friday June 03 2022, @02:57PM

          by Anonymous Coward on Friday June 03 2022, @02:57PM (#1250243)

          > It sucked

          It still sucks - to be you. Different strains of weed can make you feel giggly and sociable while others make you dissolve into a puddle of your own psyche. Sounds like your sucky friends brought the wrong shit for happy hour. Also, pro tip, don't down a bottle of vodka before going to social events. Help?

  • (Score: 2) by DannyB on Thursday June 02 2022, @06:47PM (4 children)

    by DannyB (5839) Subscriber Badge on Thursday June 02 2022, @06:47PM (#1249892) Journal

    I did not find cannabis to be very helpful with pain when I tried it. But I would be willing to try again if something better comes along.

    Prescription narcotic pain killers are great stuff. Used in moderation. I've used it almost 13-1/2 years. Last September (same day I got 3rd covid shot) I asked doctor if I could increase frequency (not dose) by 50 %. She didn't have any problem with that given how long I've taken it and not become addicted. (Hydrocodone)

    Plus, prescription narcotic pain killers are $5 for a bottle of 30 after insurance. And they're not all that expensive even without insurance. Cannabis is way more expensive. Especially in edible forms.

    I would try it again. But I'm really not sold on it. Narcotics work. Every time. Just don't use it unless you really need it. If you get to where it doesn't work, then you have a problem.

    --
    How often should I have my memory checked? I used to know but...
    • (Score: 2) by DannyB on Thursday June 02 2022, @07:10PM

      by DannyB (5839) Subscriber Badge on Thursday June 02 2022, @07:10PM (#1249908) Journal

      Tulsa mass shooter allegedly gunned down his doctor after asking for help with pain [go.com]


      A patient gunned down his surgeon and three other people in a mass shooting [go.com] at a Tulsa, Oklahoma, medical building on Wednesday after blaming the doctor for his pain, according to police.

      On May 19, the suspected gunman underwent back surgery. [go.com] Dr. Preston Phillips -- one of the four people killed in the shooting at the Natalie Building, a five-story medical complex at Saint Francis Hospital -- was the suspect's doctor in that surgery, Tulsa Police Chief Wendell Franklin said at a news conference Thursday.

      A letter recovered on the suspect, Michael Louis, made it clear "that he came with the intent to kill Dr. Phillips and anyone who got in his way," Franklin said. "He blamed Dr. Phillips for the ongoing pain following the surgery."

      Louis bought an AR-style semi-automatic rifle just hours before the shooting, Franklin said. He bought a 40-caliber pistol from a pawn shop on May 29, police said. Both appeared to be legally purchased, police said.

      The three others killed were Dr. Stephanie Husen, office employee Amanda Green and patient William Love, Franklin said.

      --
      How often should I have my memory checked? I used to know but...
    • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @10:49PM

      by Anonymous Coward on Thursday June 02 2022, @10:49PM (#1250002)

      > I did not find cannabis to be very helpful with pain when I tried it.

      Funny, because I did not find narcotic pain killers very helpful with perceiving the totalitarian world government mind control when I tried it.

    • (Score: 0) by Anonymous Coward on Friday June 03 2022, @12:25AM

      by Anonymous Coward on Friday June 03 2022, @12:25AM (#1250028)

      No kidding narcotics are better for actually removing the pain. Weed is not a painkiller, it merely helps you relax, so more of pain management for those that don't want opioids. My guess is the mild psychoactive nervous system stimulation reduces the feedback loop of pain our brains love to latch on to, or they increase other nerve signals thus reducing the effectiveness of the pain signals. I am no neuroscientist, just wanted to clarify that weed is not meant as a direct replacement for opioids.

    • (Score: 2) by mcgrew on Friday June 03 2022, @12:27AM

      by mcgrew (701) <publish@mcgrewbooks.com> on Friday June 03 2022, @12:27AM (#1250029) Homepage Journal

      No drug works for everyone. Acetaminophen does nothing for me, but most say it works for them. OTOH naproxen sodium is better than aspirin for me, some can't even take it. And weed probably doesn't help all kinds of pain, but it works for my arthritis, if the weather allows it.

      --
      Carbon, The only element in the known universe to ever gain sentience
  • (Score: 0) by Anonymous Coward on Thursday June 02 2022, @10:24PM

    by Anonymous Coward on Thursday June 02 2022, @10:24PM (#1249983)

    can they make it make LSD instead of THC?
    or a mold that only grows on harvested cannabis stems?
    extra points if it can make fruiting body too ^_^

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