Prostate Cancer Hijacks Tumor Cells' Circadian Rhythm To Evade Hormone Therapy:
Hormone treatment is successful at controlling metastatic prostate cancer, but the tumor cells eventually develop resistance to it. An unexpected potential solution has now emerged in medicines that are not designed to fight cancer, but rather to target proteins that regulate a cell's circadian rhythm.
[...] Prostate cancer is a form of tumor that develops under the influence of hormones, primarily testosterone. Patients with metastatic prostate cancer are frequently treated with anti-hormonal therapy, which inhibits the signal sent out by testosterone that stimulates tumor growth.
Anti-hormonal therapy can keep prostate cancer under control for a time, but eventually, the cancer manages to progress despite ongoing treatment. The tumor cells have become resistant. This means that the greatest challenge in treating metastatic prostate cancer isn't to find drugs that inhibit tumor growth itself, but to find drugs that can prevent resistance to hormonal therapy. The exact process of how tumor cells become resistant to hormone therapy, however, has been a mystery — until now.
An international team of researchers led by scientists from the Netherlands Cancer Institute and Oncode Institute has made a surprising discovery using tissue from patients with prostate cancer who had been treated with testosterone-inhibiting drugs. They found that an unexpected class of proteins, namely proteins that normally regulate the circadian clock, dampens the effects of the anti-hormonal therapy. "Prostate cancer cells no longer have a circadian rhythm," says Wilbert Zwart, one of the research leaders. "But these 'circadian clock' proteins acquire an entirely new function in the tumor cells upon hormonal therapy: they keep these cancer cells alive, despite treatment. This has never been seen before."'Drug repurposing could save a decade or research'
Now that they have discovered the tumor's escape route, the researchers will next work together with Oncode towards the development of novel strategies to block this process, and ultimately increase the efficacy of anti-hormonal therapy against prostate cancer even further.
Reference: 27 June 2022, Cancer Discovery.
DOI: 10.1158/2159-8290.CD-21-0576
(Score: 1, Informative) by Anonymous Coward on Tuesday June 28 2022, @05:23PM (1 child)
The article: "Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence"
Non-paywalled version: https://www.medrxiv.org/content/10.1101/2021.11.02.21265806v1 [medrxiv.org]
Which means, cells either already carry circuitry that can do this repurposing (what for?), or are capable of developing it anew without going through the DNA mutation route.
BTW, an interesting related phenomenon: https://en.wikipedia.org/wiki/Transdifferentiation [wikipedia.org]
(Score: -1, Troll) by Anonymous Coward on Tuesday June 28 2022, @08:13PM
Wow, thank you for that. I was once set up on a blind date. "Woman" turned out to be crossdresser. Some transdifferentiation would have saved a lot of time, embarrassment, and cringing.
(Score: -1, Spam) by Anonymous Coward on Thursday June 30 2022, @12:42AM
Your signature's YOUR UNDOING:
"Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss hosts files"
You must be a NO-MIND: Especially as I SHOT YOU DOWN discussing hosts making YOU the SMALLEST NO MIND since I easily tore you apart with FACTS (i.e./e.g. - Paralyzing botnets is EASY if you have the C2 & other servers it uses information - FACT & why security articles post Indicators of Compromise (IOC)).
---
Dalek EXTERMINATED by APK (again)!
No small wonder he got rid of his OLD SIGNATURE of "exterminate", lol - especially after ALL of the below FACTS:
FACT: Hosts work vs. Symbiote C2 server(s) per this line from a MUCH better article than the one used here from bradley13 per "configuration in the binary that used the git[.]bancodobrasil[.]dev domain as its C2 server" from https://www.intezer.com/blog/research/new-linux-threat-symbiote/ [intezer.com]
& did I block that in my original posts here https://soylentnews.org/comments.pl?noupdate=1&sid=49835&page=1&cid=1253504#commentwrap [soylentnews.org] on this BOGUS sockpuppet upmodding yourselves shithole website (which also noted FIREWALLS are invaluable here too, per wildcards (or even IP address use, URL domain/subdomain too in many as well))?
YES I DID! I was correct!
FACT: hosts files block symbiote C2 servers which is all you really need to do to nullify their communication.
FACT: Exfiltration isn't possible without orders either.
FACT: Orders come from C2 servers!
And what did you say to ME hypocrite?
I showed real results doctors had on video stating it themselves.
YET All you do is cite MSM VERY FAKE NEWS!
Proven TONS of times to be so in fact along with their "fact checkers" !
I put up what PHD and MDs by the truckload literally let us see (not just YOUR MSM "russia, Russia, RUSSIA" disproven in COURTS vs. Trump very fake news)?
Do as I say not as I do right dalek?
You are a hypocrite BS artist that CONTRADICTS himself!
More from your losing attempt @ DEBATING me (you = IGNORANT FOOL in this area of genetics & TOTALLY undereducated in it - whereas by COMPARISON I am not):
THIS IS ALL ABOUT GENETICS!
WHAT IS mRNA after all?
ANSWER = A part of protein synthesis involving mRNA, tRNA, & rRNA for the creation of DNA!
IF RNA single helix strands JOIN improperly into a NEW double-helix DNA (via Guanine, Adenine, Cytosine & Thymine) it creates ERRORS (cancer is 1 possible bad one, mutations another etc.)
See NHEJ below.
dalek - have you taken any genetics coursework?
I have & got A's (as my science elective requirement during my CS degreework)!
1st of all, TONS of vaccines have used poisonous Graphene oxide (or dioxide) as ADJUVANTS over time.
Secondly: ELECTRON MICROSCOPY EXPERT Dr. Young SHOWS POISONOUS GRAPHENE IN VACCINES ALSO:
https://www.brighteon.com/9e58bf44-05e7-4b71-97e5-b243f6cf890c [brighteon.com]
&
https://www.brighteon.com/9fbd7735-b49d-4e31-a146-f67d7eb54d75 [brighteon.com]
GRAPHENE OXIDE's in Pfizer, Moderna, Johnson & Johnson (Janssen) + AstraZeneca:
https://www.brighteon.com/6d8fcfd7-4811-4e64-90c9-bd5585b59ff5 [brighteon.com]
&
A major cause of myocarditis, clotting, CANCER MALIGNANCY etc.? That's right: GRAPHENE OXIDE.
Graphene Oxide Promotes Cancer Metastasis https://pubmed.ncbi.nlm.nih.gov/31877027/ [nih.gov]
An Israeli study PROVES that the NHEJ (non-homologous end joining) mechanism in your cells is DAMAGED by SPIKE PROTEINS in the death vax & IT IS LINKED TO CANCER per https://naturalnews.com/2021-11-02-covid-vaccines-inhibit-dna-repair-cause-cancer.html [naturalnews.com]
All FROM my +5 upmodded post on COVID killshots (which they HAVE proven to be on TONS of levels) https://soylentnews.org/comments.pl?noupdate=1&sid=46034&page=1&cid=1197563#commentwrap [soylentnews.org]
LOL: Well, there's the BS you state WHERE YOU ATTACKED ME only to DESTROY YOURSELF for me - thank you, lol!
HOW IRONIC!
(Dalek "EXTERMINATED" not only by FACTS from experts in microscopy, but DALEK'S own WORDS he has to EAT, lol!)
NOW THE "ICING ON THE CAKE" EXPOSING YOU, sockpuppeteer UPMODDING YOURSELF obviously + downmod bombing scumbag - RIGHT FROM YOU once more:
* THANKS FOR SHOWING US YOUR "MODUS OPERANDI" SOCKPUPPETEER troll! Fakename & all for a FAKE like you!
APK
P.S.=> THIS? This was just "too, Too, TOO EASY - just '2ez'" & it always IS vs. hypocrites like you, fakename... apk