Arthur T Knackerbracket has processed the following story:
by University of Texas at Dallas
In a study published July 29 in Advanced Materials, University of Texas at Dallas researchers found that X-rays of the kidneys using gold nanoparticles as a contrast agent might be more accurate in detecting kidney disease than standard laboratory blood tests. Based on their study in mice, they also found that caution may be warranted in employing renal-clearable nanomedicines to patients with compromised kidneys.
Before administering renal-clearable drugs, doctors routinely check a patient's kidney function by testing their blood urea nitrogen (BUN) and creatinine (Cr) levels. With the increasing use of engineered nanoparticles to deliver payloads of drugs or imaging agents to the body, an important question is how the nanoparticles' movement and elimination through the kidney is affected by kidney damage. Can traditional biomarkers like BUN and Cr accurately predict how well—or how poorly—such nanoparticles will move through the kidneys?
The UT Dallas researchers found that in mice with severely injured kidneys caused by the drug cisplatin, in which BUN and Cr levels were 10 times normal, nanoparticle transport through the kidneys was slowed down significantly, a situation that caused the nanoparticles to stay in the kidneys longer.
In mildly injured kidneys, however, in which BUN and Cr levels were only four to five times higher than normal, the transport and retention of gold nanoparticles couldn't be predicted by those tests.
On the other hand, the amount of gold nanoparticle accumulation seen on X-rays did correlate strongly with the degree of kidney damage.
"While our findings emphasize the need for caution when using these advanced treatments in patients with compromised kidneys, they also highlight the potential of gold nanoparticles as a noninvasive way to assess kidney injuries using X-ray imaging or other techniques that correlate with gold accumulation in the kidneys," said Dr. Mengxiao Yu, a corresponding author of the study and a research associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics.
Chemistry and biochemistry research scientist Xuhui Ning BS'14, Ph.D.'19 is lead author of the study, and Dr. Jie Zheng, professor of chemistry and biochemistry and a Distinguished Chair in Natural Sciences and Mathematics, is a corresponding author. Other contributors are affiliated with UT Southwestern Medical Center and Vanderbilt University Medical Center.
More information: Xuhui Ning et al, Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers, Advanced Materials (2024). DOI: 10.1002/adma.202402479
Journal information: Advanced Materials
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We live at a time when technology is increasing at a faster pace than we have ever seen before in all of human history. But is humanity equipped to handle the extremely bizarre technology that we are now developing? Earlier this month, I discussed some of the frightening ways that AI is changing our society. Today, I want to focus on nanotechnology. This is a field where extraordinary advances are https://soylentnews.org/article.pl?sid=24/09/26/1353235 being made on a regular basis, and we are being told that nanotechnology is already "revolutionizing myriad industries"...
A "nanoparticle" is a particle of matter that is less than 100 nanometers in diameter. Highly specialized equipment is necessary to work with nanoparticles, because they are way too small to be seen with the naked eye...
One of the hallmarks of nanotechnology is the utilization of nanoparticles, minute entities often ranging from 1 to 100 nanometers. These particles, when engineered with precision, bring forth distinctive characteristics that can redefine the functionality of materials. In medicine, for instance, nanoparticles serve as drug carriers, enabling targeted delivery and enhancing therapeutic efficacy while minimizing side effects. Nano-engineered materials have found their niche in the realm of electronics.
[...] Many are concerned that the healthcare industry is one area where nanoparticles are already being used on a widespread basis...
The healthcare sector is witnessing a transformative impact through nanotechnology. Nanomedicine, an interdisciplinary field, employs nanoscale tools for the diagnosis, imaging, and treatment of diseases. Nanoparticles, with their ability to navigate biological barriers, offer a novel approach to targeted drug delivery, ensuring precise and efficient treatment with reduced side effects.
[...] But there have been other developments in this field that are rather ominous.
For example, a team of researchers in South Korea has discovered a way to use nanoparticles to "control the minds of mice"...
Scientists at the Institute for Basic Science (IBS) in South Korea have developed a new way to control the minds of mice by manipulating nanoparticle-activated "switches" inside their brains with an external magnetic field.
The system, dubbed Nano-MIND (Magnetogenetic Interface for NeuroDynamics), works by controlling targeted regions of the brain by activating neural circuits.
Using an external magnetic field, these scientists were able to make mice eat more or eat less. And in another experiment, they were able to manipulate the maternal behavior of female mice...
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(Score: 1, Touché) by Anonymous Coward on Friday September 27 2024, @06:26PM
With all those "microplastics" floating around inside of us, let's just layer them into microchips.