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"Age-related neurodegenerative diseases, like Alzheimer's, progress over a long period of time before they become clinically apparent. The earliest physiological and molecular events are largely unknown," said Mastroeni. "Findings from our laboratory have uncovered early expression changes in nuclear-encoded, but not mitochondrial-encoded mRNAs occurring in one's early 30s, giving us a glimpse into what we suspect are some of the earliest cellular changes in the progression of Alzheimer's disease."
Results of the new study show that specific classes of genes associated with mitochondrial cell respiration display reduced expression levels in patients with Alzheimer's disease, compared with normal patients.
The study also examines gene expression in subjects whose brains show an intermediate level of illness known as mild cognitive impairment. Here, the opposite effect is observed, with relevant genes exhibiting increased levels of expression. The authors suggest this observation may point to some kind of compensatory mechanism in the brain attempting to stave off the disease in its earlier stages.
Further, the study proposes that restoring a specific set of damaged genes linked to mitochondrial function and located in the nuclear DNA of cells may offer a promising strategy for halting the disease's advance.
Journal: Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Alzheimer's and Dementia, 2016; DOI: 10.1016/j.jalz.2016.09.003
Simply put, the mitochondria run out of gas, and Alzheimer's follows.
(Score: 2) by RamiK on Friday November 11 2016, @09:53PM
That's an oxymoron. Given the freedom to change the thesis to match the results, you'd still get a paper off saying "Alzheimer doesn't directly affect power in the brain" instead.
That's to say, you'd need a compensatory mechanism* to explain why the author needed a compensatory mechanism instead of changing the thesis... That's one dull razor.
*A third factor the likes of not wanting to deviate from the research grant proposal wouldn't be completely out of the question if this was some pharma research. But this is basic research so what's the point?
compiling...