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Rare byproduct of marine bacteria kills cancer cells by snipping their DNA:
Yale University researchers have determined how a scarce molecule produced by marine bacteria can kill cancer cells, paving the way for the development of new, low-dose chemotherapies.
The molecule, lomaiviticin A, was previously shown to be lethal to cultured human cancer cells, but the mechanism of its operation remained unsolved for well over a decade. In a series of experiments, Yale scientists Seth Herzon, Peter Glazer, and colleagues show that the molecule nicks, cleaves, and ultimately destroys cancer cells' DNA, preventing replication.
"DNA is one of the primary targets of anticancer agents, and cleavage of both DNA chains is the most potent form of DNA damage," said Herzon, professor of chemistry. "But few anticancer agents are able to directly cleave DNA. The discovery that lomaiviticin A is capable of this suggests it could be very useful as a novel chemotherapy, possibly at low doses."
The abstract and paper can be found here.
(Score: 1) by sbgen on Tuesday May 13 2014, @06:28PM
I **wanted** to read this article, the mechanism is of interest to me, Sad to say it is behind pay-wall, even inside from a university library (supported by taxpayers, including myself). The abstract says the article actually describes a pathway by which this chemical causes double-strand DNA breaks. There probably is data to indicate that the compound could be targeted to cancerous cells but I will have to read the paper first to say that. Essentially that will cost ~$30 for the library to get it for me.
Let me shake my head again at that wall and sigh for our future progress.
Warning: Not a computer expert, but got to use it. Yes, my kind does exist.