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Scientists claim to have reversed some aspects of aging in mice by using a modified FOXO4-p53 interfering peptide:
A drug that can reverse aspects of ageing has been successfully trialled in animals, say scientists. They have rejuvenated old mice to restore their stamina, coat of fur and even some organ function. The team at Erasmus University Medical Center, in the Netherlands, are planning human trials for what they hope is a treatment for old age. A UK scientist said the findings were "impossible to dismiss", but that unanswered questions remained.
The approach works by flushing out retired or "senescent" cells in the body that have stopped dividing. They accumulate naturally with age and have a role in wound healing and stopping tumours. But while they appear to just sit there, senescent cells release chemicals that cause inflammation and have been implicated in ageing. The group of scientists created a drug that selectively killed senescent cells by disrupting the chemical balance within them. "I got very rebellious, people insisted I was crazy for trying and for the first three times they were right," Dr Peter de Keizer told the BBC.
Also at Science Magazine and NBF.
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (DOI: 10.1016/j.cell.2017.02.031) (DX)
The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function, and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can also be restored. Here, we identify FOXO4 as a pivot in senescent cell viability. We designed a FOXO4 peptide that perturbs the FOXO4 interaction with p53. In senescent cells, this selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis. Under conditions where it was well tolerated in vivo, this FOXO4 peptide neutralized doxorubicin-induced chemotoxicity. Moreover, it restored fitness, fur density, and renal function in both fast aging XpdTTD/TTD and naturally aged mice. Thus, therapeutic targeting of senescent cells is feasible under conditions where loss of health has already occurred, and in doing so tissue homeostasis can effectively be restored.
(Score: 2) by Justin Case on Monday March 27 2017, @01:43PM
You certainly seemed to have a jolly old time demonizing me, someone you don't even know.
You're right. It is wrong to think of people as groups such as "the left" or "the rich". My comments were based on conversations with many others who hold views similar to what you expressed, such as hating "the rich" so much you want them to die.
Actually we've been able to do it [post scarcity] since about the 1920s
In the context of this article, we're not yet able to reverse aging today. And you don't want us to move toward that future until the supply of materials and skilled people is enough to extend the lives of some 7 or 8 billion people. If we can't save everyone, you want us to save no one. Because equality.
OK, let's talk about equality. Proponents frequently conflate the concepts of equal opportunity and equal outcome. The existence of different results is proof of injustice, because since everyone is identical, different outcomes can only be explained by discrimination and hate. C'mon, does anyone really believe that or are those just the talking points? If you take two people, give them equal opportunity to participate in a race, and one runs while the other relaxes in the shade, who is responsible for the unequal outcomes?
you're on record that you'd rather see people die
Most won't own up to this facet of their beliefs. You did. That's rare and noteworthy. Because many lefties seem to be ruled by the feelz, they tend to flinch away from the cognitive dissonance of openly acknowledging the natural outcome of their propaganda, even though, secretly or sometimes not so secretly, they hate "the rich" so much they want to see them all suffer and die. (After which, I wonder, from whom do they plan to steal next?)
I don't think that it was a good idea to limit such advantages to a few instead of giving it to everybody.
You're still pretending there's enough to go around. What happens when there isn't? Who is going to "give" it to everybody? The omnipotent benevolent politicians? They don't have it to give. All they can do is take from the only group that it is still OK to hate, "the rich".
atrocities ... were due to his being a dictator, not a socialist or communist. He was authoritarian on the political scale
But you can't steal on such a mind-boggling scope without being an authoritarian. And yes I'm familiar with the multi-dimensional political compass.
So let's get back to "the rich". You know each of them, personally? You have examined their lives and found that every one of them obtained their wealth through crime, fraud, and so on? Not one of them ever earned anything? Not even your sports or entertainment heroes? So "the rich" get your death sentence for their imagined crimes. This, sir, is groupthink and prejudice. If you have evidence that some subset of "the rich" have stolen, defrauded etc., (and I'm not denying that some have) then you and I would agree (I think) that those individuals (not the group) should return their ill gotten gains plus a penalty. But to paint them all with one brush and then condemn them to death for unspecified flaws... well that doesn't fit any concept of justice that I recognize.