Stories
Slash Boxes
Comments

SoylentNews is people

posted by Fnord666 on Wednesday May 31 2017, @05:48PM   Printer-friendly
from the interesting-results dept.

Submitted via IRC for TheMightyBuzzard

A drug discovered more than 100 years ago may hold the key to combating autism symptoms, according to a study.

Researcher Dr Robert Naviaux of the San Diego School of Medicine gave suramin, a drug first developed in 1916, to 10 autistic boys between the ages of five and 14, and noted transformative results.

"After the single dose, it was almost like a roadblock had been released," he said. "If the future studies show that there's continued health benefits, this could be a game-changer for families with autism."

The study, which has been published in the Annals of Clinical and Translational Neurology, saw five of the participants receive suramin, while the remainder were given placebos. Included in the group were four non-verbal children – two six year olds and two 14 year olds.

"The six year old and the 14 year old who received suramin said the first sentences of their lives about one week after the single suramin infusion," Naviaux told the UC San Diego Health website. "This did not happen in any of the children given the placebo."

Source: https://www.rt.com/usa/390222-autism-research-suramin-symptoms/


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
(1)
  • (Score: 5, Funny) by krishnoid on Wednesday May 31 2017, @05:52PM (2 children)

    by krishnoid (1156) on Wednesday May 31 2017, @05:52PM (#518404)

    It's a vaccine.

    • (Score: 1, Offtopic) by takyon on Wednesday May 31 2017, @05:57PM (1 child)

      by takyon (881) <{takyon} {at} {soylentnews.org}> on Wednesday May 31 2017, @05:57PM (#518409) Journal

      No, it's a fidget spinner.

      --
      [SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
      • (Score: -1, Offtopic) by Anonymous Coward on Wednesday May 31 2017, @06:20PM

        by Anonymous Coward on Wednesday May 31 2017, @06:20PM (#518427)

        No, it's devil grass?

  • (Score: 2) by Bobs on Wednesday May 31 2017, @05:56PM (9 children)

    by Bobs (1462) on Wednesday May 31 2017, @05:56PM (#518407)

    Exciting - looking forward to seeing results replicated with a much larger group of people.

    • (Score: 5, Insightful) by DannyB on Wednesday May 31 2017, @06:00PM (7 children)

      by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:00PM (#518411) Journal

      More exciting -- looking forward to this hundred year old drug costing $100,000 per dose.

      One man's replicated results with a larger group of people is another man's 'job killing burdensome regulations'.

      --
      Would a Dyson sphere [soylentnews.org] actually work?
      • (Score: 4, Insightful) by bob_super on Wednesday May 31 2017, @06:05PM (3 children)

        by bob_super (1357) on Wednesday May 31 2017, @06:05PM (#518415)

        "Upon further review by our company's scientists, the drug has significant side-effects and is too dangerous to use. However, the new patented strawberry-flavored version has passed all our tests with flying colors, despite all the sacrifices we had to make in order to reduce our manufacturing costs to only $17899 per ml."

        • (Score: 2) by DannyB on Wednesday May 31 2017, @06:38PM (1 child)

          by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:38PM (#518434) Journal

          . . . furthermore, our new drug must be taken weekly for life.

          We don't need no steenkin' single-dose cures. What we need is an ongoing treatment. And just for spite we're going to make it an injection children take rather than an orally taken medication. Think of the children.

          --
          Would a Dyson sphere [soylentnews.org] actually work?
          • (Score: 1, Insightful) by Anonymous Coward on Wednesday May 31 2017, @07:50PM

            by Anonymous Coward on Wednesday May 31 2017, @07:50PM (#518486)

            A great many people are perfectly happy to consume daily doses of caffeine to function in the waking world.

        • (Score: 1, Informative) by Anonymous Coward on Wednesday May 31 2017, @07:49PM

          by Anonymous Coward on Wednesday May 31 2017, @07:49PM (#518484)

          https://en.wikipedia.org/wiki/Suramin#Adverse_reactions [wikipedia.org]

          Thankfully, the way this works is to reset stuck cells so it works once and you're done.

      • (Score: 2) by c0lo on Wednesday May 31 2017, @07:19PM (1 child)

        by c0lo (156) on Wednesday May 31 2017, @07:19PM (#518462) Journal

        More exciting -- looking forward to this hundred year old drug costing $100,000 per dose.

        Never been a better time to be autistic in Africa - just become ill with African sleeping sickness or river blindness and the cost of the whole treatment is free if you live countries where the diseases are common.

        --
        https://www.youtube.com/watch?v=aoFiw2jMy-0
        • (Score: 4, Informative) by c0lo on Wednesday May 31 2017, @07:22PM

          by c0lo (156) on Wednesday May 31 2017, @07:22PM (#518465) Journal

          Doh, the lost link [wikipedia.org]:

          Suramin is a medication used to treat African sleeping sickness and river blindness...
          In regions of the world where the disease is common suramin is provided for free by the World Health Organization.

          --
          https://www.youtube.com/watch?v=aoFiw2jMy-0
      • (Score: 2) by davester666 on Thursday June 01 2017, @06:56AM

        by davester666 (155) on Thursday June 01 2017, @06:56AM (#518729)

        Oh, they want to inject it into a larger group of people...specifically, everybody, and for only a modest 5 figure fee per dose.

        they only object to giving it to anyone else for free. because that would literally kill their shareholders and ceo.

    • (Score: 3, Interesting) by JoeMerchant on Thursday June 01 2017, @12:21PM

      by JoeMerchant (3937) on Thursday June 01 2017, @12:21PM (#518804)

      This crap has been circulating for 15+ years. Metabolic pathway charts on physicians' walls, theories about blocked pathways and all we have to do is repair them. Here's an anecdotal case about Urocholine infusion restoring speech in an autistic child from years ago:

      http://www.whale.to/vaccines/megson.html [whale.to]

      The doc that promoted that would like you to buy some pure arctic cod liver oil from her to potentially help your autistic child speak again.

      This time we have two responders from a group of four non-verbals, and as a bonus there's an age spread from 6 to 14 - more hope.

      Please, please, please filter this crap until you have more positive results than can be counted on fingers and toes. ~60,000 births per day in the developed world where the diagnosed autism rate is ~1:68. So, 1000 new autism diagnoses PER DAY, and we're publishing results about a study of 10 with "2 dramatic positive responders within a week."

      Give this guy funding for a bigger study, not publicity.

      --
      Україна досі не є частиною Росії Слава Україні🌻 https://news.stanford.edu/2023/02/17/will-russia-ukraine-war-end
  • (Score: 2, Informative) by Anonymous Coward on Wednesday May 31 2017, @05:59PM (17 children)

    by Anonymous Coward on Wednesday May 31 2017, @05:59PM (#518410)

    From Wikipedia:

    Suramin is a medication used to treat African sleeping sickness and river blindness. It is the treatment of choice for sleeping sickness without central nervous system involvement. It is given by injection into a vein.
    [...] Suramin was made at least as early as 1916. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. In the United States it can be acquired from the Center for Disease Control (CDC). The cost of the medication for a course of treatment is about 27 USD.

    Bold added by me.

    https://en.wikipedia.org/wiki/Suramin [wikipedia.org]

    • (Score: 2) by DannyB on Wednesday May 31 2017, @06:02PM (15 children)

      by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:02PM (#518413) Journal

      a course of treatment is about 27 USD

      You can bet that will change.

      --
      Would a Dyson sphere [soylentnews.org] actually work?
      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:06PM

        by Anonymous Coward on Wednesday May 31 2017, @06:06PM (#518417)

        No bet

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:15PM (11 children)

        by Anonymous Coward on Wednesday May 31 2017, @06:15PM (#518424)

        It's almost as if it takes resources to do to things in this universe.

        • (Score: 5, Insightful) by DannyB on Wednesday May 31 2017, @06:40PM

          by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:40PM (#518437) Journal

          It's almost as if some people have no problem vastly enriching themselves on the back of other people's pain and suffering in this universe.

          And those television commercials don't come for free you know.

          --
          Would a Dyson sphere [soylentnews.org] actually work?
        • (Score: 3, Interesting) by VLM on Wednesday May 31 2017, @06:47PM (9 children)

          by VLM (445) on Wednesday May 31 2017, @06:47PM (#518441)

          It's almost as if it takes resources to do to things in this universe.

          “This work is new and this type of clinical trial is expensive,” he said. “We did not have enough funding to do a larger study. And even with the funding we were able to raise, we had to go $500,000 in debt to complete the trial.”

          I have to WTF at that a little bit, they dosed 10 kids at apparently far over $50K per kid although the dose itself cost about $27. I'm sure they spent in excess of $49973 per kid on something, but I donno what.

          Could I make a working nuclear reactor with half a million bucks? I think maybe. It would have to be a heavy water homogenized "CANDU" style, but yeah.. If I need 100 pounds or so of heavy water and its about a buck a mL thats like fifty grand and lets say a hundred pounds of natural uranium ore and some gear... Now could I find a way to spend the other $400K on P.I. (that being me) salary, well sure...

          • (Score: 2, Informative) by Anonymous Coward on Wednesday May 31 2017, @07:02PM (1 child)

            by Anonymous Coward on Wednesday May 31 2017, @07:02PM (#518448)

            Medical evaluation of the patients, checking for adverse effects, tracking outcomes, study design, data analysis, regulatory paperwork, etc.

            The cost of the drug itself is usually minimal compared to the rest of a trial's cost (possibly exempting biologic drugs such as antibodies).

            • (Score: 2) by sjames on Saturday June 03 2017, @10:59PM

              by sjames (2882) on Saturday June 03 2017, @10:59PM (#520005) Journal

              Even with all of that and assuming we give them a 100% ROI on their research, each patient can kick in a 1 time fee of $1.00 and cover the lot of it.

          • (Score: 3, Insightful) by Translation Error on Wednesday May 31 2017, @07:07PM (6 children)

            by Translation Error (718) on Wednesday May 31 2017, @07:07PM (#518453)
            The cost of the medicine is hardly what makes the clinical trial expensive. Lab work, monitoring, neurological exams, blood work, evaluation, plus a bunch of other things I'm sure I haven't thought of... Just the wages for the people doing all this and the cost for lab use & tests would add up to quite a bit.
            • (Score: 2, Disagree) by VLM on Wednesday May 31 2017, @07:19PM (4 children)

              by VLM (445) on Wednesday May 31 2017, @07:19PM (#518461)

              Yeah OK putting "medical" on anything makes the price 100x whatever.

              None the less, just saying, from a normie non-medical perspective, for way over $500K we're expecting a real world implementation of "The Fly" or "Spiderman"

              Either that or we're expecting better sets and special effects for "The Fly" or "Spiderman"

              • (Score: 2) by Aiwendil on Wednesday May 31 2017, @08:56PM (2 children)

                by Aiwendil (531) on Wednesday May 31 2017, @08:56PM (#518510) Journal

                Either that or we're expecting better sets and special effects for "The Fly" or "Spiderman"

                The fun part here is that he became The Fly by failing to perform sufficient animal studies before progressing to humans. A clear case of when proper testing procedures would have been beneficial.

                • (Score: -1, Offtopic) by Anonymous Coward on Wednesday May 31 2017, @09:05PM (1 child)

                  by Anonymous Coward on Wednesday May 31 2017, @09:05PM (#518515)

                  Not at all true since he did plenty of rigorous testing and yet he still became The Fly because the machine had a failure mode which he had not even considered to be possible.

                  • (Score: 3, Informative) by Immerman on Thursday June 01 2017, @12:58AM

                    by Immerman (3985) on Thursday June 01 2017, @12:58AM (#518611)

                    Hardly rigorous if something as ubiquitous as a fly hadn't occurred yet. And why *wouldn't* he have considered such a failure mode (I'm assuming it was simply the presence of the fly, not some other independent failure mode that happened simultaneously? I don't think I ever actually saw it)

                    And that's ignoring the fact that the entire premise is a bit ridiculous - if a teleporter accident somehow fused the DNA of the beings being teleported - both man and fly would heavily outnumbered by skin mites, not to mention bacteria - our cells are outnumbered by what, like 100-to-one by the bacteria living within us? Though I'll admit "The Bacteria" would have been a much tougher sell as a horror movie.

              • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:33PM

                by Anonymous Coward on Wednesday May 31 2017, @10:33PM (#518538)

                OK, I agree let's skip it. No research into anything that costs more than $5 upfront.

                How about we also do no military adventures unless they pay for themselves with sweet oil revenue?

            • (Score: 2) by sjames on Saturday June 03 2017, @11:09PM

              by sjames (2882) on Saturday June 03 2017, @11:09PM (#520010) Journal

              Most of that is FAR less expensive to provide than the end patient will be charged. On a one off basis, you're kind of stuck with it, but if you own your own lab and do the tests at cost, it's not that much. Of course when you want to make it look dreadfully expensive, you pretend that the cost you would bill someone for the work is what it actually cost you to use your otherwise idle lab.

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:59PM (1 child)

        by Anonymous Coward on Wednesday May 31 2017, @06:59PM (#518446)

        A course of treatment for autism may be very different (chronic?) than that of sleeping sickness (acute). The paper mentions "low-dose suramin", but the real cost of the treatment would probably be monitoring the patient response and not the drug itself.

        • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:37PM

          by Anonymous Coward on Wednesday May 31 2017, @10:37PM (#518541)

          SHUT UP!!! THEY SAID IT COSTS $27 WHY ARE YOU GOUGING PATIENTS $$$$ WHO WOULD OTHERWISE HAVE AUTISM FOR LIFE??????

          THINK OF THE.... THINK OF THE.... THINK OF SOMETHING OUTRAGEOUS!!!!!!!!! MAKES ME MAD!!!!!!!!!!!

    • (Score: 2) by c0lo on Wednesday May 31 2017, @07:26PM

      by c0lo (156) on Wednesday May 31 2017, @07:26PM (#518470) Journal

      From the same source:

      In regions of the world where the disease is common suramin is provided for free by the World Health Organization.

      If they start charging ridiculous prices, I foresee a notable increase of medical tourism towards African countries, where the drug is available and doctors have wages in hundreds of dollars/year.

      --
      https://www.youtube.com/watch?v=aoFiw2jMy-0
  • (Score: -1, Flamebait) by Anonymous Coward on Wednesday May 31 2017, @06:06PM (4 children)

    by Anonymous Coward on Wednesday May 31 2017, @06:06PM (#518418)

    If you gave a miracle autismo cure to a 30-something year old Chris-Chan, or even a 10 year old, they would still have to work hard to understand the ways of the world and overcome their own shitty behavior.

    • (Score: -1, Troll) by Anonymous Coward on Wednesday May 31 2017, @06:32PM

      by Anonymous Coward on Wednesday May 31 2017, @06:32PM (#518433)

      Fuck you shit head! Go suck a nigger!!

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:35PM (1 child)

      by Anonymous Coward on Wednesday May 31 2017, @07:35PM (#518475)

      they would still have to work hard to understand the ways of the world

      Perhaps not. Much of the problem of not understanding the world is related to not paying any attention to social cues. For example someone who doesn't make eye contact is going to have extreme difficulty interpreting facial expressions if they don't even look at the other person during a conversation. If the miracle cure only makes them more receptive to social stimuli then they might well learn to understand the ways of the world naturally.

      • (Score: 1, Insightful) by Anonymous Coward on Thursday June 01 2017, @01:38AM

        by Anonymous Coward on Thursday June 01 2017, @01:38AM (#518624)

        What? That can't be! How can I feel better about myself if I can't bash people less fortunate than me?! Especially if I can't ensure that they stay less fortunate than me...?

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:39PM

      by Anonymous Coward on Wednesday May 31 2017, @10:39PM (#518542)

      Oh noes, better not bother then.

  • (Score: 2) by infodragon on Wednesday May 31 2017, @06:17PM (2 children)

    by infodragon (3509) on Wednesday May 31 2017, @06:17PM (#518426)

    It's all fffffFFFFFake!!!!!!!!!!!!!

    Joking aside, if this can be duplicated then this will be an amazing "miracle" for 1000s of families. Anybody with any experience with autism knows it's not just the one with autism that suffers, their families are impacted as well!

    --
    Don't settle for shampoo, demand real poo!
    • (Score: 2) by Weasley on Wednesday May 31 2017, @09:11PM (1 child)

      by Weasley (6421) on Wednesday May 31 2017, @09:11PM (#518519)

      It may be fake news, but nobody will be able to the difference after they pull the charred story from the wreckage of your warp shuttle, Senator Vreenak.

      • (Score: 2) by infodragon on Thursday June 01 2017, @11:26AM

        by infodragon (3509) on Thursday June 01 2017, @11:26AM (#518784)

        So now the Russians are making moves stolen from the Romulan playbook! Genius!!!

        Does that make the US the Founders and Russia the Federation? I sense a Soviet Russia joke but that's from a parallel universe.

        --
        Don't settle for shampoo, demand real poo!
  • (Score: 5, Informative) by shipofgold on Wednesday May 31 2017, @06:23PM

    by shipofgold (4696) on Wednesday May 31 2017, @06:23PM (#518428)

    Russia Today is always a trusted source, but here is the link to the original press release:

    https://health.ucsd.edu/news/topics/Suramin-Autism/Pages/default.aspx [ucsd.edu]

    Important note at the bottom:

    Special note from the researchers: Suramin is not approved for the treatment of autism. Like many intravenous drugs, when administered improperly by untrained personnel, at the wrong dose and schedule, without careful measurement of drug levels and monitoring for toxicity, suramin can cause harm. Careful clinical trials will be needed over several years at several sites to learn how to use low-dose suramin safely in autism, and to identify drug-drug interactions and rare side effects that cannot currently be predicted. We strongly caution against the unauthorized use of suramin.

    I am guessing that there are a lot of parents rushing to the phones calling their local doctors to see if they can get their children an "off label" infusion.

  • (Score: 5, Interesting) by Anonymous Coward on Wednesday May 31 2017, @06:26PM (31 children)

    by Anonymous Coward on Wednesday May 31 2017, @06:26PM (#518430)

    OK, the auties who can't talk probably need help. But as someone with a more moderate case, I don't want anything turning me neurotypical.

    Within the "talking autie" community we have a certain level of disregard for neurotypicals. It's like you have a mental disability. Can't stay focused on a task. Can't pay attention to detail. Obsessed with peer approval. Unable to think and behave outside the hive mind.

    I don't want any of that.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:40PM (19 children)

      by Anonymous Coward on Wednesday May 31 2017, @06:40PM (#518436)

      Well let's see now, if all you self-obsessed freaks with your tunnel-vision and inability to function socially take this treatment, suddenly you'll stop whining for basic income to make the rest of us pay you to be worthless leeches. Hey guess what, treating you with drugs is cheaper than taxing everybody to pay your basic income. That settles it. You're getting the drugs.

      • (Score: 2) by DannyB on Wednesday May 31 2017, @06:47PM (12 children)

        by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:47PM (#518440) Journal

        The hyperfocus / socially inept group that is well paid to make the things everyone else wants, are hardly the leeches.

        Maybe you're thinking of the "can't code my way out of a paper bag" in between googling for snippets of already written code, while reading FaceTwit crowd.

        --
        Would a Dyson sphere [soylentnews.org] actually work?
        • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:15PM (11 children)

          by Anonymous Coward on Wednesday May 31 2017, @07:15PM (#518458)

          You're hilarious because you think the hyperfocused socially inept group have jobs making the social media platforms everyone else wants. Coding is not a solitary endeavor anymore. You work in a social group or you don't work at all. Look at GitHub and you see the successful coders who have jobs are those whose profiles look the most like social media profiles.

          The "can't code my way out of a paper bag" crowd are fully in control and they create more drama than code. They debate fiercely about irrelevant minutia of coding styles and codes of conduct which are more important than functioning code. They make decisions about whether to accept code based upon the social circle of the contributor instead of the merits of the code itself.

          The solitary coders who don't have profile pics and don't have followers and don't chat with their friends in the issue trackers and are just hyperfocused coders who concentrate on coding are the unemployed basement dwellers who don't make any money.

          • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:58PM (7 children)

            by Anonymous Coward on Wednesday May 31 2017, @07:58PM (#518487)

            The solitary coders who ... don't chat with their friends ... are the unemployed basement dwellers who don't make any money.

            Original thread AC here. While you all socialize, I break your shit. It's ridiculously easy, because you can't code, you can just copy, imitate, and pose.

            Because you can't focus on detail, you don't even understand how the layers of abstraction (often fail to) interact. I do, because I can remember technical arcania I saw only once, years ago.

            Some industries still need reliable code, and are willing to pay for it. My work in QA has provided me a very comfortable income, TYVM.

            • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @08:28PM (6 children)

              by Anonymous Coward on Wednesday May 31 2017, @08:28PM (#518496)

              Let me guess, you don't work in isolation. You report to a boss to whom you write reports. You know just how much irrelevant social posturing you need to lace into your reports to keep your job.

              I can do QA too but I can't get paid for it, because my idea of QA is firing off a patch with a note that says, "Yo fuckface cuz joo too stoopid to fix yoor fucking shit I debugged it for joo now joo take my fucking patch and you fucking merge that sucker right now up yoor fucking ass!!!"

              As you can tell, I don't have any patience for idiots and their broken code. Fixing the code is only half the job, and I'm really bad at the other half which is communicating the results.

              • (Score: 5, Interesting) by c0lo on Wednesday May 31 2017, @09:24PM (5 children)

                by c0lo (156) on Wednesday May 31 2017, @09:24PM (#518522) Journal

                Let me guess, you don't work in isolation.

                No, but the others have enough common sense to let me focus on what I do best.

                You report to a boss to whom you write reports. You know just how much irrelevant social posturing you need to lace into your reports to keep your job.

                Nope, the boss generates the reports from Jira, nobody in the team needs to waste their time with collating reports.
                If this happens to you, then it sucks to work where you are.
                Believe it or not, there are places in which managers really understand their job: they are the enablers for the actual doers, not leeches.

                I can do QA too but I can't get paid for it, because my idea of QA is firing off a patch with a note that says, "Yo fuckface cuz joo too stoopid to fix yoor fucking shit I debugged it for joo now joo take my fucking patch and you fucking merge that sucker right now up yoor fucking ass!!!"

                See where your focus on socializing leads you? If you just limit your communication to the problem at hand and explain why it breaks and when/where it breaks, everybody would benefit. No "social communication" skills involved, just stick to the engineering problem.

                As you can tell, I don't have any patience for idiots and their broken code. Fixing the code is only half the job, and I'm really bad at the other half which is communicating the results.

                I guess no amount of suramin is going to help you.

                ---

                (and no, I'm not any of the AC-es above, but I can sympathize with the original AC)

                --
                https://www.youtube.com/watch?v=aoFiw2jMy-0
                • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @09:47PM (1 child)

                  by Anonymous Coward on Wednesday May 31 2017, @09:47PM (#518526)

                  Gimme basic income, pruneface.

                  • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @12:13AM

                    by Anonymous Coward on Thursday June 01 2017, @12:13AM (#518590)

                    Gimme basic income, pruneface.

                    sudo "take it yourself, figass".

                • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @02:43AM (2 children)

                  by Anonymous Coward on Thursday June 01 2017, @02:43AM (#518646)

                  Interesting. In the other thread you said you smoke about 20 a day. There is some evidence that many smokers are actually non-neurotypicals self-medicating with nicotine.
                  Do you get more or less autistic when you don't smoke? Serious question as, from memory, the nicotine was a help with ADHD which is sort of the opposite end of the spectrum.

                  • (Score: 2) by c0lo on Thursday June 01 2017, @03:23AM (1 child)

                    by c0lo (156) on Thursday June 01 2017, @03:23AM (#518665) Journal

                    There is some evidence that many smokers are actually non-neurotypicals self-medicating with nicotine.

                    I feel there's an element of truth in my case.
                    There's also an element of puzzlement - I tried vaping and find unsatisfying after a while - I'm not alone, I have a colleague in almost the same situation now - he's vaping as a substitute but now and then comes to pinch a real cigie from me. I reckon the other stuff the manufacturers put into the cigarettes somehow helps the delivery to the areas in need.

                    Do you get more or less autistic when you don't smoke?

                    I'm not in the autistic spectrum, even if sometimes (in my "larval stages") it may seems so. I think I'm closer to a bipolar.
                    Nicotine helps in dampening the extremes: makes the depressive periods less acute, steals from the joy of intense activity and getting a lot of things done on the expense of physical/physiological needs.

                    --
                    https://www.youtube.com/watch?v=aoFiw2jMy-0
                    • (Score: 3, Informative) by sjames on Sunday June 04 2017, @12:04AM

                      by sjames (2882) on Sunday June 04 2017, @12:04AM (#520023) Journal

                      There's a few possibilities. One is that cigarettes also contain harmaline, a MAOI that greatly potentiates the nicotine (especially it's addictivness). MAOIs have also been used as anti-depressants on their own (not so much anymore).

                      Some people find that upping the nicotine dose to compensate helps a lot. Those wimpy cigalikes they sell at the mall probably can't deliver a proper dose. You need something in the 75-150 watt range. Personally I like a 0.5 ohm 24 gauge stainless steel coil and an 18650 battery rated for 30A discharge.

          • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @08:35PM (2 children)

            by Anonymous Coward on Wednesday May 31 2017, @08:35PM (#518501)

            You're hilarious because you think the hyperfocused socially inept group have jobs making the social media platforms everyone else wants. Coding is not a solitary endeavor anymore. You work in a social group or you don't work at all. Look at GitHub and you see the successful coders who have jobs are those whose profiles look the most like social media profiles.

            Engineering in general is very collaborative as well, gone are the days of sitting in your cube or office and never having to talk to anyone else to get the project completed. You will need to pick up the phone time to time or even walk over and talk to someone in person rather than just sending emails. When I was last at an engineering conference and some kids asked me for advice during an outreach session I simply told them "don't neglect your soft skills, the world doesn't need more engineers who can't communicate and get along with others."

            • (Score: 2) by fyngyrz on Wednesday May 31 2017, @08:45PM (1 child)

              by fyngyrz (6567) on Wednesday May 31 2017, @08:45PM (#518505) Journal

              Engineering in general is very collaborative as well

              Mmm. Well, you know, there are still some engineering types out here that are producing things on their own. You can speculate on why that might be, and sometimes, in some cases, you might even be right... but where you're not right is assuming that engineering in general requires collaboration. Some engineering types are perfectly capable of doing large, complex, many-faceted projects. Software and hardware. If you had one or two of those around, you might find you need a lot less collaboration and a lot more marketing. You also might be a little more cautious about those claims. :)

              • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @08:58PM

                by Anonymous Coward on Wednesday May 31 2017, @08:58PM (#518511)

                It doesn't matter if the engineer is any good; what matters is how much social media buzz the engineer makes for self marketing.

      • (Score: 2) by VLM on Wednesday May 31 2017, @07:16PM (1 child)

        by VLM (445) on Wednesday May 31 2017, @07:16PM (#518459)

        Hey guess what, treating you with drugs is cheaper than taxing everybody to pay your basic income. That settles it. You're getting the drugs.

        Aside from the autists, can we implement this for the libertarian-left?

        • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @02:55AM

          by Anonymous Coward on Thursday June 01 2017, @02:55AM (#518652)

          It's a (possible) cure for autism, not an intelligence boost.

      • (Score: 4, Informative) by Anonymous Coward on Wednesday May 31 2017, @07:42PM (1 child)

        by Anonymous Coward on Wednesday May 31 2017, @07:42PM (#518479)

        That's already a thing in the USA.
        Specifically, in Alaska.
        Since 1976.
        It's called The Alaska Permanent Fund.

        the rest of us pay you

        That's not how they do it in Alaska.
        The money comes from "the commonwealth".
        Unlike other (clueless, corporate puppet) states who give away for free the privilege to do mineral extraction, Alaska charges corporations for that.
        When ExxonMobil drills for oil in Alaska, the fund gets a cut and once a year that fund is disbursed equally among all the residents of Alaska.

        As mentioned, it has worked just fine for decades.

        ...though a job that pays a living wage for every USAian would be even better.
        ...if only the people who "represent us" in DC would stop subsidizing the exporting of USAian jobs.

        -- OriginalOwner_ [soylentnews.org]

        • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @01:00PM

          by Anonymous Coward on Thursday June 01 2017, @01:00PM (#518827)

          This is not quite how it works. The Permanent Fund is controlled by the Alaskan Permanent Fund Corporation, which invests the fund in various bonds/stocks/etc. Every year, they payout a dividend to every eligible resident that applies for it (the Permanent Fund Dividend, know locally as the PFD). The payout is based on the earnings averaged over 5 years, and so varies from several hundred dollars to a few thousand. The actual fund itself is not split up, and I am unsure how much corporations actually pay into it anymore. I believe it was a one time levy that is now self sustaining.
          Unsurprisingly, the state legislature is constantly trying to raid the fund to balance out some budget shortfall, usually with the promise of a final payout in the range of ten thousand dollars per resident. So far the residents have not fallen for it.

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:49PM (1 child)

        by Anonymous Coward on Wednesday May 31 2017, @07:49PM (#518483)

        When crabs are in a bucket, they pull back down any crabs that try to clamber out and escape.

        • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @01:41AM

          by Anonymous Coward on Thursday June 01 2017, @01:41AM (#518626)

          I've never heard that one before. Interesting. I don't care if it's not true like the boiling frogs. It just sounds good and explains a complex sociological phenomenon.

          (Not being sarcastic.)

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:46PM

      by Anonymous Coward on Wednesday May 31 2017, @06:46PM (#518439)

      And you just happen to be "too autistic" to see the irony in your criticism of others and their "hive mind" when your entire post is nothing but bigotry and gross overgeneralizations that you picked up by hanging out on an extremist website?

    • (Score: 4, Interesting) by VLM on Wednesday May 31 2017, @07:06PM (5 children)

      by VLM (445) on Wednesday May 31 2017, @07:06PM (#518451)

      There's a natural alliance between the autists and the alt-right. I'm not even kidding. That cross pollination between /pol/ and /r9k/ led to some success last November, the good guys finally won one. Of course the natsoc think they deployed weaponized autism, while the Autistes more correctly observe it was the other way around and they weaponized natsoc via application of their freshest dankest memes. Behind every good alt-right nat-soc is an Autiste spinning up dank memes like a voodoo priest leading a horde of zombies. A natsoc army without its autiste priest meme spinners is like a leaderless zombie invasion, not gonna end well. An autiste meme warrior without his natsoc army is just a NEET who doesn't even lift. But put the two together on an anonymous japanese comic book image board and they select the next president of the united states. Isn't this an amazing time to be alive? The world today is so far out that you couldn't even make a sci fi novel out of it a decade ago. What actually happens today in the real world is weirder than Stross's laundry novels.

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:23PM (1 child)

        by Anonymous Coward on Wednesday May 31 2017, @07:23PM (#518467)

        Right, it was all the internet brigading on reddit and obscure forums that really turned the tide!

        You are nuts, and even think Trump represents the "good guys"? For your own safety, and the safety of others please sell / give away any weapons you've collected.

        • (Score: 2, Informative) by Arik on Wednesday May 31 2017, @08:22PM

          by Arik (4543) on Wednesday May 31 2017, @08:22PM (#518494) Journal
          Trump's far from a 'good guy' but the real world doesn't really tend to fit that comic-book level of analysis anyway.

          And Hillary makes Trump look good.
          --
          If laughter is the best medicine, who are the best doctors?
      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:59PM

        by Anonymous Coward on Wednesday May 31 2017, @07:59PM (#518488)

        the good guys finally won one

        '

        *good goys [wikipedia.org]

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @09:00PM (1 child)

        by Anonymous Coward on Wednesday May 31 2017, @09:00PM (#518513)

        exactly

        okay, you've got people paying attention to (obeying) social cues now
        unfortunately, this makes them about a billion times more susceptible to social proof and manipulation, so long story short we accidentally society and everyone's a teetotaling commie

        also /pol/ is a self-limiting problem. they don't really like/appreciate/want to maintain the autists (who are mostly into weird gay porn, anime, and meth-over-TOR), so as soon as they feel secure enough to ditch them (or, more likely, murder them), they will. you can already kind of see it on the board proper, where they consider themselves better than the rest of the site because they have people from Twitter. what this means is, they'll get rid of all the people who made them edgy and cool, and- having killed the goose that laid the golden eggs- crumble into irrelevancy. the same shit happened with the commies.
        1. provide a space for everyone who's disaffected or has a grudge against the establishment
        2. tell them you'll help them get their cut of the pie as long as they promote your #brand
        3. use them to recruit normie trendwhores
        4. as soon as you have enough normies, kristallnacht the perverts (to get normie approval and prevent anyone else from using them), eject "bad actors", and try to become the establishment
        5. coast along until enough people have a grudge against you
        6. ???
        7. get overthrown by someone who had the same idea

        anything that could break this cycle would have to be corrupt as fuck almost by definition. it would have to be able to accommodate the autists qua autists through back-channels or intentional blindness, and /pol/ (and Americans) are too good at virtue spiraling to ever learn how to do that. we're talking about guys who are in favor of flags and IDs, for fuck's sake, people who reject the basic dynamics of imageboards in favor of "reddit with random names".

        so, the cycle will continue.

        • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:31PM

          by Anonymous Coward on Wednesday May 31 2017, @11:31PM (#518573)

          You don't promote anything because it's detrimental to your own interest somewhere in time and you reject any normies that comes near. They can't be trusted, ever.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:08PM

      by Anonymous Coward on Wednesday May 31 2017, @07:08PM (#518454)

      Have a look if "Autism Speaks" is in anyway involved in this. That would tell a lot.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:22PM

      by Anonymous Coward on Wednesday May 31 2017, @10:22PM (#518535)

      Whatever it takes to help you feel superior to others, because that's what really matters. Feeling like you're better than other people is the way to a truly fulfilling life.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:50PM

      by Anonymous Coward on Wednesday May 31 2017, @10:50PM (#518547)

      Hi I read Any Rant and i kan be SuperMench too? Promis I will read ur code and u get 10x speed up instantly. Garanteed! I know C## got A+++++++++ in class.

    • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @01:54AM

      by Anonymous Coward on Thursday June 01 2017, @01:54AM (#518628)

      is that what they told you?

  • (Score: 4, Funny) by ikanreed on Wednesday May 31 2017, @06:29PM (4 children)

    by ikanreed (3164) on Wednesday May 31 2017, @06:29PM (#518432) Journal

    As treatment gradually dries up membership for tech news websites, I'll remember you all fondly.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @06:50PM (3 children)

      by Anonymous Coward on Wednesday May 31 2017, @06:50PM (#518444)

      You've been following the tech news sites so you've seen the trends. Tech nerdery is a dying art which is being replaced by social apping. Purely technical roles are disappearing back into unpaid hobbyist niches. Soft social skills are the only marketable skills and old skool autistic nerds just don't have the skills to succeed. Hardcore autistic nerds don't even have the ability to learn social skills. Maybe this treatment can help them transition into more social roles so they can continue to contribute instead of being laid off and left to die homeless and destitute.

      • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:29PM (2 children)

        by Anonymous Coward on Wednesday May 31 2017, @07:29PM (#518471)

        As long as those systems have a deplorable load of bugs they will be exploited by people with high level of technical skill.

        • (Score: 2, Funny) by Anonymous Coward on Wednesday May 31 2017, @08:02PM (1 child)

          by Anonymous Coward on Wednesday May 31 2017, @08:02PM (#518489)

          "I have people skills. I am good at dealing with people! Can't you understand that?! What the hell is wrong with you people?!"

          • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @09:21PM

            by Anonymous Coward on Thursday June 01 2017, @09:21PM (#519048)

            I think I know where that was from, but I don't want to jump to conclusions about it...

  • (Score: 2) by VLM on Wednesday May 31 2017, @06:39PM (7 children)

    by VLM (445) on Wednesday May 31 2017, @06:39PM (#518435)

    The most frequent adverse reactions are...

    Not even going to bother quoting it, but wow its quite a list. And the two month half life means if you get "changes or loss of vision" or whatever it takes months to get even a little better.

    Intramuscular and subcutaneous administration could result in ... necrosis.

    Damn... screw up the injection and the kids arm literally rots off of them. Try not to do that.

    Suramin ... has a half-life of 41–78 days

    temporarily reversed symptoms

    OK so at least you get like four treatments per year, not daily or something.

    Suramin does not distribute well into cerebral spinal fluid and its concentration in the tissues is equivalently lower than its concentration in the plasma.

    Yeah thats not pointing to a neurological cause of autism. Although lower conc does not mean zero.

    Suramin is not extensively metabolized and about 80% is eliminated via the kidneys.

    Fits in with the pharmacokinetic widely varying rate, drink a lot of water pee out in 40 days what a dehydrated dude would keep for 80 days.

    It sounds biochemistry scary as hell. Which makes sense, lots of Autism money to go around and eventually the chemists are going to scare up something as terrifying as chemotherapy level substances that kill the autism just a little worst than they kill the patient.

    • (Score: 2) by kaszz on Wednesday May 31 2017, @07:02PM (5 children)

      by kaszz (4211) on Wednesday May 31 2017, @07:02PM (#518449) Journal

      doi/10.1002/acn3.424 [wiley.com] on toxity:

      The low dose of suramin used in this study produced blood levels of 1.5–15 μmol/L for 6 weeks. Previous studies have never examined the side-effect profile of suramin in this low-dose range. The side-effect profile of high-dose suramin (150–270 μmol/L) is known from cancer chemotherapy studies.[32] The side-effect profile from medium-dose suramin (50–100 μmol/L) is known from African sleeping sickness studies.[46] However, the side-effect profile of low-dose suramin (5–15 μmol/L) used for antipurinergic therapy (APT) in autism is unknown. Low-dose suramin was found to be safe in five children with ASD, ages 5–14 years, in this study.

      As for greed:

      Conflict of Interest

      RKN has filed a provisional patent application related to antipurinergic therapy of autism and related disorders and is a scientific advisory board member for the Autism Research Institute and the Open Medicine Foundation. EVC is a DSMB member for Cempra Pharmaceuticals and The Medicines Company, and a consultant for Alexion. SG is co-owner of MitoMedical. The other authors declare no conflicts of interest.

      • (Score: 2) by VLM on Wednesday May 31 2017, @07:09PM (4 children)

        by VLM (445) on Wednesday May 31 2017, @07:09PM (#518456)

        Oooh interesting. Of course treatment for ASD would seem to be weekly for life so the long term low dose will also be interesting to study. Hopefully a tolerance doesn't build up.

        • (Score: 2) by kaszz on Wednesday May 31 2017, @07:17PM (3 children)

          by kaszz (4211) on Wednesday May 31 2017, @07:17PM (#518460) Journal

          I'll suspect there's a difference between people that have autism and asperger. In that people with autism really do have issues that blocks them from being happy. And a medicine like this might unlock certain regions of the brain. What to watch out for is people that are so determined to make these persons an image of their self and their preferences that they will are willing to seriously hurt the person they think they help but in reality will just make things worse.

          Before this can really be evaluated a larger trial will most likely be needed.

          • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:46PM (2 children)

            by Anonymous Coward on Wednesday May 31 2017, @07:46PM (#518482)

            I suspect asperger are high IQ autistic who are able to cope by using their advanced intelligence to overcome some of their issues.

            • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @10:57PM (1 child)

              by Anonymous Coward on Wednesday May 31 2017, @10:57PM (#518551)

              Interesting. As for my opinion, I suspect Jesus touches certain minds and Satan touches others. We should discuss on TV - remember it doesn't cost anything to pray to Jesus.

              • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:15PM

                by Anonymous Coward on Wednesday May 31 2017, @11:15PM (#518563)

                Great Satan hear my prayer.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @07:07PM

      by Anonymous Coward on Wednesday May 31 2017, @07:07PM (#518452)

      From the paper:

      The terminal half-life was 14.7 ± 0.7 days. A self-limited, asymptomatic rash was seen, but there were no serious adverse events

      The dose makes the poison.

  • (Score: 2) by DannyB on Wednesday May 31 2017, @06:49PM (1 child)

    by DannyB (5839) Subscriber Badge on Wednesday May 31 2017, @06:49PM (#518443) Journal

    It's a good thing they named it Suramin instead of Sauron.

    --
    Would a Dyson sphere [soylentnews.org] actually work?
    • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @01:54PM

      by Anonymous Coward on Thursday June 01 2017, @01:54PM (#518849)

      In some languages, like arabic or hebrew, vowels make no difference to the meaning of a word. So in effect, "Suramin" would be the same name as "Saruman".

  • (Score: 2) by ilsa on Wednesday May 31 2017, @07:23PM (1 child)

    by ilsa (6082) Subscriber Badge on Wednesday May 31 2017, @07:23PM (#518466)

    Word of advise... don't read the comments on that article. The amount of breathtaking stupidity makes me want to cry. It's like the entire anti-vax-iverse descended on that article and are spewing every nonsensical meme they can think of.

    • (Score: 3, Insightful) by kaszz on Wednesday May 31 2017, @07:36PM

      by kaszz (4211) on Wednesday May 31 2017, @07:36PM (#518476) Journal

      Here or elsewhere?

  • (Score: 2) by Phoenix666 on Wednesday May 31 2017, @08:04PM (2 children)

    by Phoenix666 (552) on Wednesday May 31 2017, @08:04PM (#518490) Journal

    Let's hope this result proves out. It sounds like a miracle. The last time there was such a clear medical triumph was when they figure out how to fix ulcers.

    --
    Washington DC delenda est.
    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:01PM

      by Anonymous Coward on Wednesday May 31 2017, @11:01PM (#518556)

      The last time there was such a clear medical triumph

      There was an HCV cure developed not too long ago and cancer immunotherapy has cured cancer in many people. Those results are pretty clear.

    • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:05PM

      by Anonymous Coward on Wednesday May 31 2017, @11:05PM (#518558)

      its a shame the lay public need "triumphs" (Trumps) to convince them of medical progress. if you could only learn about public health coverage then all sorts of incremental advances would be available to you. the thing about incremental advances are... they increment and they increment... and suddenly, with apparently no warning to the lay public, you get a "triumph". like Trump i want to skip all the intermediate bullshit and just WIN. which button is that on my computer? i'm looking for the WIN key. i've already called microsoft - useless. i'm looking for WIN on my keyboard, where is that?

  • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:39PM

    by Anonymous Coward on Wednesday May 31 2017, @11:39PM (#518578)

    The test they used is called "ADOS-2". Reading about it was unenlightening. Does anyone have experience with that?

  • (Score: 0) by Anonymous Coward on Wednesday May 31 2017, @11:43PM (1 child)

    by Anonymous Coward on Wednesday May 31 2017, @11:43PM (#518582)

    "The six year old and the 14 year old who received suramin said the first sentences of their lives about one week after the single suramin infusion,"

    What did they say? I hope not something like "Ow, it hurts".

    • (Score: 2) by Bot on Friday June 02 2017, @08:03AM

      by Bot (3902) on Friday June 02 2017, @08:03AM (#519268) Journal

      "ow it hurts" would be a good outcome.
      A bad outcome would be "GIVE ME MORE, NOW!!!"

      --
      Account abandoned.
  • (Score: 0) by Anonymous Coward on Thursday June 01 2017, @02:00AM

    by Anonymous Coward on Thursday June 01 2017, @02:00AM (#518629)

    Now wouldn't it be hilarious if Thiremosal was a key ingredient to this cure?

(1)