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posted by martyb on Thursday August 03 2017, @10:47PM   Printer-friendly
from the the-best-made-plans-of-mice-and-men... dept.

The human embryo editing study first reported by MIT Technology Review last week has been published in Nature. Scientists led by the Oregon Health & Science University's Shoukhrat Mitalipov edited human embryos to remove the MYBPC3 mutation associated with hypertrophic cardiomyopathy:

The experiment corrected the defect in nearly two-thirds of several dozen embryos, without causing potentially dangerous mutations elsewhere in the DNA.

None of the embryos were used to try to create a baby. But if future experiments confirm the techniques are safe and effective, the scientists say the same approach could be used to prevent a long list of inheritable diseases. "Potentially, we're talking about thousands of genes and thousands of patients," says Paula Amato, an associate professor of obstetrics and gynecology at Oregon Health & Science University in Portland. She was a member of the scientific team from the U.S., China and South Korea.

[...] Amato and others stress that their work is aimed at preventing terrible diseases, not creating genetically enhanced people. And they note that much more research is needed to confirm the technique is safe and effective before anyone tries to make a baby this way. But scientists hoping to continue the work in the U.S. face many regulatory obstacles. The National Institutes of Health will not fund any research involving human embryos (the new work was funded by Oregon Health & Science University). And the Food and Drug Administration is prohibited by Congress from considering any experiments that involve genetically modified human embryos.

Nevertheless, the researchers say they're hopeful about continuing the work, perhaps in Britain. The United Kingdom has permitted genetic experiments involving human embryos forbidden in the United States. "If other countries would be interested, we would be happy to work with their regulatory bodies," says Shoukhrat Mitalipov, director of the Oregon Health & Science University's Center for Embryonic Cell and Gene Therapy.

Also at NYT, MIT, BBC, Science Magazine, and Scientific American.

Correction of a pathogenic gene mutation in human embryos (open, DOI: 10.1038/nature23305) (DX)

Previously: First Known Attempt at Genetically Modifying Human Embryos in the U.S. is an Apparent Success


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  • (Score: 2) by MichaelDavidCrawford on Thursday August 03 2017, @11:43PM

    by MichaelDavidCrawford (2339) Subscriber Badge <mdcrawford@gmail.com> on Thursday August 03 2017, @11:43PM (#548523) Homepage Journal

    Her name is French for "wings", as in Angel wings.

    Her mother was feeling her biological clock ticking, so she scouted around for a man with "good genes". To his great surprise, he became a father. To both of their great surprise, they are carriers for Recessive Polycystic Kidney Disease.

    Both of Ailes' kidneys were surgically removed when she was less than a week old. They are now in a jar of formaldehyde and on display at Stanford Medical Center.

    Ailes got her transplant when she was 3 1/2. I think she's eight years old now.

    --
    Yes I Have No Bananas. [gofundme.com]
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